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Items: 1 to 20 of 127

1.

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.

Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massagué J.

Mol Cell. 2009 Nov 13;36(3):457-68. doi: 10.1016/j.molcel.2009.09.043.

3.

Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.

Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T.

J Biol Chem. 2009 Mar 6;284(10):6109-15. doi: 10.1074/jbc.M804659200. Epub 2009 Jan 4.

4.

Phospho-Smad1 modulation by nedd4 E3 ligase in BMP/TGF-β signaling.

Kim BG, Lee JH, Yasuda J, Ryoo HM, Cho JY.

J Bone Miner Res. 2011 Jul;26(7):1411-24. doi: 10.1002/jbmr.348. Erratum in: J Bone Miner Res. 2012 Jun;27(6):1437.

5.

Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling.

Yan X, Liao H, Cheng M, Shi X, Lin X, Feng XH, Chen YG.

J Biol Chem. 2016 Jan 1;291(1):382-92. doi: 10.1074/jbc.M115.694281. Epub 2015 Nov 10.

PMID:
26555259
6.
7.

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation.

Kamato D, Burch ML, Piva TJ, Rezaei HB, Rostam MA, Xu S, Zheng W, Little PJ, Osman N.

Cell Signal. 2013 Oct;25(10):2017-24. doi: 10.1016/j.cellsig.2013.06.001. Epub 2013 Jun 11. Review.

PMID:
23770288
8.

C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.

Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S.

J Biol Chem. 2014 May 2;289(18):12680-92. doi: 10.1074/jbc.M114.558981. Epub 2014 Mar 13.

9.

Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state.

Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R.

J Biol Chem. 2013 Jun 21;288(25):18546-60. doi: 10.1074/jbc.M112.446591. Epub 2013 May 6.

10.

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.

Seo SR, Lallemand F, Ferrand N, Pessah M, L'Hoste S, Camonis J, Atfi A.

EMBO J. 2004 Oct 1;23(19):3780-92. Epub 2004 Sep 9.

11.

DDB2 modulates TGF-β signal transduction in human ovarian cancer cells by downregulating NEDD4L.

Zhao R, Cui T, Han C, Zhang X, He J, Srivastava AK, Yu J, Wani AA, Wang QE.

Nucleic Acids Res. 2015 Sep 18;43(16):7838-49. doi: 10.1093/nar/gkv667. Epub 2015 Jun 29.

12.

Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling.

Wrighton KH, Willis D, Long J, Liu F, Lin X, Feng XH.

J Biol Chem. 2006 Dec 15;281(50):38365-75. Epub 2006 Oct 10.

13.
14.

Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.

Mavrakis KJ, Andrew RL, Lee KL, Petropoulou C, Dixon JE, Navaratnam N, Norris DP, Episkopou V.

PLoS Biol. 2007 Mar;5(3):e67.

15.

TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos.

Redshaw N, Camps C, Sharma V, Motallebipour M, Guzman-Ayala M, Oikonomopoulos S, Thymiakou E, Ragoussis J, Episkopou V.

PLoS One. 2013;8(1):e55186. doi: 10.1371/journal.pone.0055186. Epub 2013 Jan 30.

16.

Pin1 promotes transforming growth factor-beta-induced migration and invasion.

Matsuura I, Chiang KN, Lai CY, He D, Wang G, Ramkumar R, Uchida T, Ryo A, Lu K, Liu F.

J Biol Chem. 2010 Jan 15;285(3):1754-64. doi: 10.1074/jbc.M109.063826. Epub 2009 Nov 17.

17.

Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling.

Hough C, Radu M, Doré JJ.

PLoS One. 2012;7(8):e42513. doi: 10.1371/journal.pone.0042513. Epub 2012 Aug 6.

18.

TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.

Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL.

Nat Cell Biol. 2001 Jun;3(6):587-95.

PMID:
11389444
19.

Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells.

Kamato D, Rostam MA, Piva TJ, Babaahmadi Rezaei H, Getachew R, Thach L, Bernard R, Zheng W, Little PJ, Osman N.

J Pharm Pharmacol. 2014 Dec;66(12):1722-33. doi: 10.1111/jphp.12298. Epub 2014 Oct 14.

PMID:
25316549
20.
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