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Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats.

Paul KB, Hedge JM, DeVito MJ, Crofton KM.

Toxicol Sci. 2010 Feb;113(2):367-79. doi: 10.1093/toxsci/kfp271. Epub 2009 Nov 12.


Long-term effects of the antibacterial agent triclosan on marine periphyton communities.

Eriksson KM, Johansson CH, Fihlman V, Grehn A, Sanli K, Andersson MX, Blanck H, Arrhenius Å, Sircar T, Backhaus T.

Environ Toxicol Chem. 2015 Apr 22. doi: 10.1002/etc.3030. [Epub ahead of print]


The commonly used antimicrobial additive triclosan is a liver tumor promoter.

Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17200-5. doi: 10.1073/pnas.1419119111. Epub 2014 Nov 17.


Effects of triiodothyronine on turnover rate and metabolizing enzymes for thyroxine in thyroidectomized rats.

Nagao H, Sasaki M, Imazu T, Takahashi K, Aoki H, Minato K.

Life Sci. 2014 Oct 29;116(2):74-82. doi: 10.1016/j.lfs.2014.09.016. Epub 2014 Sep 28.


Fasting-induced changes in hepatic thyroid hormone metabolism in male rats are independent of autonomic nervous input to the liver.

de Vries EM, Eggels L, van Beeren HC, Ackermans MT, Kalsbeek A, Fliers E, Boelen A.

Endocrinology. 2014 Dec;155(12):5033-41. doi: 10.1210/en.2014-1608. Epub 2014 Sep 22.


Effects of triclosan on the detoxification system in the yellow catfish (Pelteobagrus fulvidraco): expressions of CYP and GST genes and corresponding enzyme activity in phase I, II and antioxidant system.

Ku P, Wu X, Nie X, Ou R, Wang L, Su T, Li Y.

Comp Biochem Physiol C Toxicol Pharmacol. 2014 Nov;166:105-14. doi: 10.1016/j.cbpc.2014.07.006. Epub 2014 Jul 24.


Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDP-glucuronosyltransferase in female rats.

Kawase A, Ito A, Yamada A, Iwaki M.

Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):239-44. doi: 10.1007/s13318-014-0208-7. Epub 2014 Jun 5.


Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products.

Witorsch RJ.

Crit Rev Toxicol. 2014 Jul;44(6):535-55. doi: 10.3109/10408444.2014.910754. Epub 2014 Jun 4. Review.


Recent evidence regarding triclosan and cancer risk.

Dinwiddie MT, Terry PD, Chen J.

Int J Environ Res Public Health. 2014 Feb 21;11(2):2209-17. doi: 10.3390/ijerph110202209. Review.


3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver.

Kato Y, Haraguchi K, Onishi M, Ikushiro S, Endo T, Ohta C, Koga N, Yamada S, Degawa M.

Biol Pharm Bull. 2014;37(3):504-9. Epub 2013 Dec 17.


Hepatic cytochrome P450s, phase II enzymes and nuclear receptors are downregulated in a Th2 environment during Schistosoma mansoni infection.

Mimche SM, Nyagode BA, Merrell MD, Lee CM, Prasanphanich NS, Cummings RD, Morgan ET.

Drug Metab Dispos. 2014 Jan;42(1):134-40. doi: 10.1124/dmd.113.054957. Epub 2013 Oct 25.


Effects of a chronic lower range of triclosan exposure on a stream mesocosm community.

Nietch CT, Quinlan EL, Lazorchak JM, Impellitteri CA, Raikow D, Walters D.

Environ Toxicol Chem. 2013 Dec;32(12):2874-87.


Rutaecarpine effects on expression of hepatic phase-1, phase-2 metabolism and transporter genes as a basis of herb-drug interactions.

Zhu QN, Zhang D, Jin T, Wu Q, Liu J, Lu YF.

J Ethnopharmacol. 2013 May 2;147(1):215-9. doi: 10.1016/j.jep.2013.03.005. Epub 2013 Mar 16.


Regulation of hepatic phase II metabolism in pregnant mice.

Wen X, Donepudi AC, Thomas PE, Slitt AL, King RS, Aleksunes LM.

J Pharmacol Exp Ther. 2013 Jan;344(1):244-52. doi: 10.1124/jpet.112.199034. Epub 2012 Oct 10.


The effects of clobazam treatment in rats on the expression of genes and proteins encoding glucronosyltransferase 1A/2B (UGT1A/2B) and multidrug resistance-associated protein-2 (MRP2), and development of thyroid follicular cell hypertrophy.

Miyawaki I, Tamura A, Matsumoto I, Inada H, Kunimatsu T, Kimura J, Funabashi H.

Toxicol Appl Pharmacol. 2012 Dec 15;265(3):351-9. doi: 10.1016/j.taap.2012.09.003. Epub 2012 Sep 12.


Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action.

Paul KB, Hedge JM, Bansal R, Zoeller RT, Peter R, DeVito MJ, Crofton KM.

Toxicology. 2012 Oct 9;300(1-2):31-45. doi: 10.1016/j.tox.2012.05.023. Epub 2012 Jun 1.


CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats.

Roques BB, Lacroix MZ, Puel S, Gayrard V, Picard-Hagen N, Jouanin I, Perdu E, Martin PG, Viguié C.

Toxicol Sci. 2012 May;127(1):29-41. doi: 10.1093/toxsci/kfs094. Epub 2012 Mar 22. Erratum in: Toxicol Sci. 2012 Dec;130(2):444-5. Dosage error in article text.


N-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats.

Yang Y, Ciurlionis R, Kowalkowski K, Marsh KC, Bracken WM, Blomme EA.

Toxicol Lett. 2012 Jan 5;208(1):82-91. doi: 10.1016/j.toxlet.2011.10.012. Epub 2011 Oct 20.


UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.

Xu J, Kulkarni SR, Li L, Slitt AL.

Drug Metab Dispos. 2012 Feb;40(2):259-66. doi: 10.1124/dmd.111.039925. Epub 2011 Oct 26.

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