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Results: 1 to 20 of 105

1.

Mechanism of DNA-protein cross-linking by chromium.

Macfie A, Hagan E, Zhitkovich A.

Chem Res Toxicol. 2010 Feb 15;23(2):341-7. doi: 10.1021/tx9003402.

PMID:
19877617
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Carcinogenic chromium(VI) induces cross-linking of vitamin C to DNA in vitro and in human lung A549 cells.

Quievryn G, Messer J, Zhitkovich A.

Biochemistry. 2002 Mar 5;41(9):3156-67.

PMID:
11863455
[PubMed - indexed for MEDLINE]
3.

Chromium(VI) causes interstrand DNA cross-linking in vitro but shows no hypersensitivity in cross-link repair-deficient human cells.

Morse JL, Luczak MW, Zhitkovich A.

Chem Res Toxicol. 2013 Oct 21;26(10):1591-8. doi: 10.1021/tx400293s. Epub 2013 Oct 8.

PMID:
24059640
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Analysis of EDTA-chelatable proteins from DNA-protein crosslinks induced by a carcinogenic chromium(VI) in cultured intact human cells.

Mattagajasingh SN, Misra HP.

Mol Cell Biochem. 1999 Sep;199(1-2):149-62.

PMID:
10544963
[PubMed - indexed for MEDLINE]
5.

Utilization of DNA-protein cross-links as a biomarker of chromium exposure.

Zhitkovich A, Voitkun V, Kluz T, Costa M.

Environ Health Perspect. 1998 Aug;106 Suppl 4:969-74.

PMID:
9703480
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Reductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI).

Zhitkovich A, Quievryn G, Messer J, Motylevich Z.

Environ Health Perspect. 2002 Oct;110 Suppl 5:729-31.

PMID:
12426121
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr(VI) with cysteine: role of ternary DNA adducts in Cr(III)-dependent mutagenesis.

Zhitkovich A, Song Y, Quievryn G, Voitkun V.

Biochemistry. 2001 Jan 16;40(2):549-60.

PMID:
11148050
[PubMed - indexed for MEDLINE]
8.

XPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromate.

Zecevic A, Hagan E, Reynolds M, Poage G, Johnston T, Zhitkovich A.

Mutagenesis. 2010 Jul;25(4):381-8. doi: 10.1093/mutage/geq017. Epub 2010 Apr 21.

PMID:
20410141
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Carcinogenic chromium(VI)-induced protein oxidation and lipid peroxidation: implications in DNA-protein crosslinking.

Mattagajasingh SN, Misra BR, Misra HP.

J Appl Toxicol. 2008 Nov;28(8):987-97. doi: 10.1002/jat.1364.

PMID:
18615841
[PubMed - indexed for MEDLINE]
10.

Formation of the amino acid-DNA complexes by hexavalent and trivalent chromium in vitro: importance of trivalent chromium and the phosphate group.

Zhitkovich A, Voitkun V, Costa M.

Biochemistry. 1996 Jun 4;35(22):7275-82.

PMID:
8679557
[PubMed - indexed for MEDLINE]
11.

Reduction of Cr (VI) by cysteine: significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates.

Quievryn G, Goulart M, Messer J, Zhitkovich A.

Mol Cell Biochem. 2001 Jun;222(1-2):107-18.

PMID:
11678591
[PubMed - indexed for MEDLINE]
12.

Genotoxicity and mutagenicity of chromium(VI)/ascorbate-generated DNA adducts in human and bacterial cells.

Quievryn G, Peterson E, Messer J, Zhitkovich A.

Biochemistry. 2003 Feb 4;42(4):1062-70.

PMID:
12549927
[PubMed - indexed for MEDLINE]
13.

Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions.

O'Brien T, Mandel HG, Pritchard DE, Patierno SR.

Biochemistry. 2002 Oct 15;41(41):12529-37.

PMID:
12369844
[PubMed - indexed for MEDLINE]
14.

Reduction of chromium(VI) by ascorbate leads to chromium-DNA binding and DNA strand breaks in vitro.

Stearns DM, Kennedy LJ, Courtney KD, Giangrande PH, Phieffer LS, Wetterhahn KE.

Biochemistry. 1995 Jan 24;34(3):910-9.

PMID:
7827049
[PubMed - indexed for MEDLINE]
15.

Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest.

O'Brien T, Xu J, Patierno SR.

Mol Cell Biochem. 2001 Jun;222(1-2):173-82.

PMID:
11678599
[PubMed - indexed for MEDLINE]
16.

Chromium genotoxicity: A double-edged sword.

Nickens KP, Patierno SR, Ceryak S.

Chem Biol Interact. 2010 Nov 5;188(2):276-88. doi: 10.1016/j.cbi.2010.04.018. Epub 2010 Apr 27. Review.

PMID:
20430016
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism.

Guttmann D, Poage G, Johnston T, Zhitkovich A.

Chem Res Toxicol. 2008 Nov;21(11):2188-94. doi: 10.1021/tx800265g.

PMID:
18808157
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate.

Zhitkovich A, Voitkun V, Costa M.

Carcinogenesis. 1995 Apr;16(4):907-13.

PMID:
7728973
[PubMed - indexed for MEDLINE]
19.

Activation of chromium(VI) by thiols results in chromium(V) formation, chromium binding to DNA and altered DNA conformation.

Borges KM, Boswell JS, Liebross RH, Wetterhahn KE.

Carcinogenesis. 1991 Apr;12(4):551-61.

PMID:
1849467
[PubMed - indexed for MEDLINE]
20.

Time‑order effects of vitamin C on hexavalent chromium‑induced mitochondrial damage and DNA‑protein crosslinks in cultured rat peripheral blood lymphocytes.

Xiao F, Chen D, Luo L, Zhong X, Xie Y, Zou L, Zeng M, Guan L, Zhong C.

Mol Med Rep. 2013 Jul;8(1):53-60. doi: 10.3892/mmr.2013.1462. Epub 2013 May 8.

PMID:
23657841
[PubMed - indexed for MEDLINE]

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