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Results: 1 to 20 of 116

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1.

Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.

Khrapunovich-Baine M, Menon V, Verdier-Pinard P, Smith AB 3rd, Angeletti RH, Fiser A, Horwitz SB, Xiao H.

Biochemistry. 2009 Dec 15;48(49):11664-77. doi: 10.1021/bi901351q.

2.

A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin.

Xia S, Kenesky CS, Rucker PV, Smith AB 3rd, Orr GA, Horwitz SB.

Biochemistry. 2006 Oct 3;45(39):11762-75.

PMID:
17002277
3.

Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach.

Canales A, Rodríguez-Salarichs J, Trigili C, Nieto L, Coderch C, Andreu JM, Paterson I, Jiménez-Barbero J, Díaz JF.

ACS Chem Biol. 2011 Aug 19;6(8):789-99. doi: 10.1021/cb200099u. Epub 2011 May 13.

PMID:
21539341
4.
5.

Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.

Khrapunovich-Baine M, Menon V, Yang CP, Northcote PT, Miller JH, Angeletti RH, Fiser A, Horwitz SB, Xiao H.

J Biol Chem. 2011 Apr 1;286(13):11765-78. doi: 10.1074/jbc.M110.162214. Epub 2011 Jan 18.

8.

Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells.

Honore S, Kamath K, Braguer D, Horwitz SB, Wilson L, Briand C, Jordan MA.

Cancer Res. 2004 Jul 15;64(14):4957-64.

9.

Insights into the mechanism of microtubule stabilization by Taxol.

Xiao H, Verdier-Pinard P, Fernandez-Fuentes N, Burd B, Angeletti R, Fiser A, Horwitz SB, Orr GA.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10166-73. Epub 2006 Jun 26.

10.

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

ter Haar E, Kowalski RJ, Hamel E, Lin CM, Longley RE, Gunasekera SP, Rosenkranz HS, Day BW.

Biochemistry. 1996 Jan 9;35(1):243-50.

PMID:
8555181
11.

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF.

Nat Chem Biol. 2007 Feb;3(2):117-25. Epub 2007 Jan 7.

PMID:
17206139
12.

A unique mode of microtubule stabilization induced by peloruside A.

Huzil JT, Chik JK, Slysz GW, Freedman H, Tuszynski J, Taylor RE, Sackett DL, Schriemer DC.

J Mol Biol. 2008 May 16;378(5):1016-30. doi: 10.1016/j.jmb.2008.03.026. Epub 2008 Mar 19.

13.

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.

Paterson I, Naylor GJ, Fujita T, Guzmán E, Wright AE.

Chem Commun (Camb). 2010 Jan 14;46(2):261-3. doi: 10.1039/b921237j. Epub 2009 Nov 24.

PMID:
20024345
14.

The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies.

Martello LA, LaMarche MJ, He L, Beauchamp TJ, Smith AB, Horwitz SB.

Chem Biol. 2001 Sep;8(9):843-55.

15.

Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.

Qi J, Blanden AR, Bane S, Kingston DG.

Bioorg Med Chem. 2011 Sep 1;19(17):5247-54. doi: 10.1016/j.bmc.2011.06.082. Epub 2011 Jul 2.

16.

The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.

Sánchez-Pedregal VM, Kubicek K, Meiler J, Lyothier I, Paterson I, Carlomagno T.

Angew Chem Int Ed Engl. 2006 Nov 13;45(44):7388-94. No abstract available.

PMID:
17036370
17.

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

Madiraju C, Edler MC, Hamel E, Raccor BS, Balachandran R, Zhu G, Giuliano KA, Vogt A, Shin Y, Fournier JH, Fukui Y, Brückner AM, Curran DP, Day BW.

Biochemistry. 2005 Nov 15;44(45):15053-63.

PMID:
16274252
18.

Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.

Raccor BS, Vogt A, Sikorski RP, Madiraju C, Balachandran R, Montgomery K, Shin Y, Fukui Y, Jung WH, Curran DP, Day BW.

Mol Pharmacol. 2008 Mar;73(3):718-26. Epub 2007 Dec 11.

19.

Discodermolide interferes with the binding of tau protein to microtubules.

Kar S, Florence GJ, Paterson I, Amos LA.

FEBS Lett. 2003 Mar 27;539(1-3):34-6.

PMID:
12650922
20.

Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation.

Wiesen KM, Xia S, Yang CP, Horwitz SB.

Cancer Lett. 2007 Nov 18;257(2):227-35. Epub 2007 Sep 14.

PMID:
17869412
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