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Results: 1 to 20 of 85

1.

Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).

Mutoh S, Osabe M, Inoue K, Moore R, Pedersen L, Perera L, Rebolloso Y, Sueyoshi T, Negishi M.

J Biol Chem. 2009 Dec 11;284(50):34785-92. doi: 10.1074/jbc.M109.048108. Epub 2009 Oct 26.

PMID:
19858220
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.

Guo D, Sarkar J, Ahmed MR, Viswakarma N, Jia Y, Yu S, Sambasiva Rao M, Reddy JK.

Biochem Biophys Res Commun. 2006 Aug 25;347(2):485-95. Epub 2006 Jun 30.

PMID:
16828057
[PubMed - indexed for MEDLINE]
3.

PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor.

Sueyoshi T, Moore R, Sugatani J, Matsumura Y, Negishi M.

Mol Pharmacol. 2008 Apr;73(4):1113-21. doi: 10.1124/mol.107.042960. Epub 2008 Jan 17.

PMID:
18202305
[PubMed - indexed for MEDLINE]
Free Article
4.

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling.

Mutoh S, Sobhany M, Moore R, Perera L, Pedersen L, Sueyoshi T, Negishi M.

Sci Signal. 2013 May 7;6(274):ra31. doi: 10.1126/scisignal.2003705.

PMID:
23652203
[PubMed - indexed for MEDLINE]
5.

Subcellular trafficking signals of constitutive androstane receptor: evidence for a nuclear export signal in the DNA-binding domain.

Xia J, Kemper B.

Drug Metab Dispos. 2007 Sep;35(9):1489-94. Epub 2007 Jun 13.

PMID:
17567731
[PubMed - indexed for MEDLINE]
Free Article
6.

The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems.

Kanno Y, Miyazaki Y, Inouye Y.

Biochim Biophys Acta. 2010 Aug;1803(8):968-74. doi: 10.1016/j.bbamcr.2010.05.004. Epub 2010 May 15.

PMID:
20478346
[PubMed - indexed for MEDLINE]
Free Article
7.
8.

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver.

Zelko I, Sueyoshi T, Kawamoto T, Moore R, Negishi M.

Mol Cell Biol. 2001 Apr;21(8):2838-46.

PMID:
11283262
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression.

Meyer SA, Jirtle RL.

Sci Signal. 2013 May 7;6(274):pe16. doi: 10.1126/scisignal.2004239.

PMID:
23652202
[PubMed - indexed for MEDLINE]
11.

Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B.

Yamamoto Y, Moore R, Flavell RA, Lu B, Negishi M.

PLoS One. 2010 Apr 12;5(4):e10121. doi: 10.1371/journal.pone.0010121.

PMID:
20404936
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm.

Osabe M, Negishi M.

J Biol Chem. 2011 Oct 14;286(41):35763-9. doi: 10.1074/jbc.M111.284596. Epub 2011 Aug 26.

PMID:
21873423
[PubMed - indexed for MEDLINE]
Free PMC Article
13.
14.

Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor.

Hosseinpour F, Moore R, Negishi M, Sueyoshi T.

Mol Pharmacol. 2006 Apr;69(4):1095-102. Epub 2005 Dec 23.

PMID:
16377764
[PubMed - indexed for MEDLINE]
Free Article
15.

Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.

Yang H, Garzel B, Heyward S, Moeller T, Shapiro P, Wang H.

Mol Pharmacol. 2014 Feb;85(2):249-60. doi: 10.1124/mol.113.089763. Epub 2013 Nov 19.

PMID:
24252946
[PubMed - indexed for MEDLINE]
16.

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.

Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA.

J Biol Chem. 2002 Jan 25;277(4):2908-15. Epub 2001 Nov 12.

PMID:
11706036
[PubMed - indexed for MEDLINE]
Free Article
17.

Localization of the nuclear receptor CAR at the cell membrane of mouse liver.

Koike C, Moore R, Negishi M.

FEBS Lett. 2005 Dec 19;579(30):6733-6. Epub 2005 Nov 21.

PMID:
16310787
[PubMed - indexed for MEDLINE]
Free Article
18.

Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR.

Ueda A, Matsui K, Yamamoto Y, Pedersen LC, Sueyoshi T, Negishi M.

Biochem J. 2005 Jun 1;388(Pt 2):623-30.

PMID:
15610065
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo.

Min G, Kemper JK, Kemper B.

J Biol Chem. 2002 Jul 19;277(29):26356-63. Epub 2002 May 8.

PMID:
12000748
[PubMed - indexed for MEDLINE]
Free Article
20.

Overexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liver.

Hosseinpour F, Timsit Y, Koike C, Matsui K, Yamamoto Y, Moore R, Negishi M.

FEBS Lett. 2007 Oct 16;581(25):4937-42. Epub 2007 Sep 21.

PMID:
17904126
[PubMed - indexed for MEDLINE]
Free PMC Article
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