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Results: 1 to 20 of 74

1.

PTEN dosage is essential for neurofibroma development and malignant transformation.

Gregorian C, Nakashima J, Dry SM, Nghiemphu PL, Smith KB, Ao Y, Dang J, Lawson G, Mellinghoff IK, Mischel PS, Phelps M, Parada LF, Liu X, Sofroniew MV, Eilber FC, Wu H.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19479-84. doi: 10.1073/pnas.0910398106. Epub 2009 Oct 21.

PMID:
19846776
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

PMID:
16854453
[PubMed - indexed for MEDLINE]
3.

Impaired Pten expression in human malignant peripheral nerve sheath tumours.

Bradtmöller M, Hartmann C, Zietsch J, Jäschke S, Mautner VF, Kurtz A, Park SJ, Baier M, Harder A, Reuss D, von Deimling A, Heppner FL, Holtkamp N.

PLoS One. 2012;7(11):e47595. doi: 10.1371/journal.pone.0047595. Epub 2012 Nov 6.

PMID:
23139750
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis.

Kazmi SJ, Byer SJ, Eckert JM, Turk AN, Huijbregts RP, Brossier NM, Grizzle WE, Mikhail FM, Roth KA, Carroll SL.

Am J Pathol. 2013 Mar;182(3):646-67. doi: 10.1016/j.ajpath.2012.11.017. Epub 2013 Jan 13.

PMID:
23321323
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.

Jessen WJ, Miller SJ, Jousma E, Wu J, Rizvi TA, Brundage ME, Eaves D, Widemann B, Kim MO, Dombi E, Sabo J, Hardiman Dudley A, Niwa-Kawakita M, Page GP, Giovannini M, Aronow BJ, Cripe TP, Ratner N.

J Clin Invest. 2013 Jan 2;123(1):340-7. doi: 10.1172/JCI60578. Epub 2012 Dec 10.

PMID:
23221341
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Potential role of 18fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with neurofibromatosis 1.

Karabatsou K, Kiehl TR, Wilson DM, Hendler A, Guha A.

Neurosurgery. 2009 Oct;65(4 Suppl):A160-70. doi: 10.1227/01.NEU.0000337597.18599.D3.

PMID:
19927062
[PubMed - indexed for MEDLINE]
7.

Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.

Vasudevan KM, Burikhanov R, Goswami A, Rangnekar VM.

Cancer Res. 2007 Nov 1;67(21):10343-50.

PMID:
17974977
[PubMed - indexed for MEDLINE]
Free Article
8.

Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications.

Gottfried ON, Viskochil DH, Couldwell WT.

Neurosurg Focus. 2010 Jan;28(1):E8. doi: 10.3171/2009.11.FOCUS09221.

PMID:
20043723
[PubMed - indexed for MEDLINE]
9.

Critical role of PTEN for development and progression of nerve sheath tumors in neurofibromatosis type 1.

Mawrin C.

Future Oncol. 2010 Apr;6(4):499-501. doi: 10.2217/fon.10.29.

PMID:
20373864
[PubMed]
Free Article
10.

PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways.

Yao D, Alexander CL, Quinn JA, Porter MJ, Wu H, Greenhalgh DA.

Cancer Res. 2006 Feb 1;66(3):1302-12.

PMID:
16452183
[PubMed - indexed for MEDLINE]
Free Article
11.

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL.

Cancer Cell. 2007 Jun;11(6):555-69.

PMID:
17560336
[PubMed - indexed for MEDLINE]
Free Article
12.

[18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) as a diagnostic tool for neurofibromatosis 1 (NF1) associated malignant peripheral nerve sheath tumours (MPNSTs): a long-term clinical study.

Ferner RE, Golding JF, Smith M, Calonje E, Jan W, Sanjayanathan V, O'Doherty M.

Ann Oncol. 2008 Feb;19(2):390-4. Epub 2007 Oct 11.

PMID:
17932395
[PubMed - indexed for MEDLINE]
Free Article
13.

Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.

Rusyn EV, Reynolds ER, Shao H, Grana TM, Chan TO, Andres DA, Cox AD.

Oncogene. 2000 Sep 28;19(41):4685-94.

PMID:
11032018
[PubMed - indexed for MEDLINE]
Free Article
14.

Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors.

Mawrin C, Kirches E, Boltze C, Dietzmann K, Roessner A, Schneider-Stock R.

Virchows Arch. 2002 Jun;440(6):610-5. Epub 2001 Nov 16.

PMID:
12070601
[PubMed - indexed for MEDLINE]
15.

Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft.

Bhola P, Banerjee S, Mukherjee J, Balasubramanium A, Arun V, Karim Z, Burrell K, Croul S, Gutmann DH, Guha A.

Int J Cancer. 2010 Jan 15;126(2):563-71. doi: 10.1002/ijc.24783.

PMID:
19634141
[PubMed - indexed for MEDLINE]
16.

Molecular evolution of a neurofibroma to malignant peripheral nerve sheath tumor (MPNST) in an NF1 patient: correlation between histopathological, clinical and molecular findings.

Spurlock G, Knight SJ, Thomas N, Kiehl TR, Guha A, Upadhyaya M.

J Cancer Res Clin Oncol. 2010 Dec;136(12):1869-80. doi: 10.1007/s00432-010-0846-3. Epub 2010 Mar 15.

PMID:
20229272
[PubMed - indexed for MEDLINE]
17.

PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.

Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA.

Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14.

PMID:
22700876
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Molecular characterization of permanent cell lines from primary, metastatic and recurrent malignant peripheral nerve sheath tumors (MPNST) with underlying neurofibromatosis-1.

Fang Y, Elahi A, Denley RC, Rao PH, Brennan MF, Jhanwar SC.

Anticancer Res. 2009 Apr;29(4):1255-62.

PMID:
19414372
[PubMed - indexed for MEDLINE]
Free Article
19.

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene.

Tolkacheva T, Chan AM.

Oncogene. 2000 Feb 3;19(5):680-9.

PMID:
10698513
[PubMed - indexed for MEDLINE]
Free Article
20.

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Wang J, Ouyang W, Li J, Wei L, Ma Q, Zhang Z, Tong Q, He J, Huang C.

Cancer Res. 2005 Aug 1;65(15):6601-11.

PMID:
16061640
[PubMed - indexed for MEDLINE]
Free Article

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