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Results: 1 to 20 of 106

1.

Deregulation of DUSP activity in EGFR-mutant lung cancer cell lines contributes to sustained ERK1/2 signaling.

Britson JS, Barton F, Balko JM, Black EP.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):849-54. doi: 10.1016/j.bbrc.2009.10.061. Epub 2009 Oct 20.

PMID:
19836351
[PubMed - indexed for MEDLINE]
2.

VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells.

Bellou S, Hink MA, Bagli E, Panopoulou E, Bastiaens PI, Murphy C, Fotsis T.

Am J Physiol Cell Physiol. 2009 Dec;297(6):C1477-89. doi: 10.1152/ajpcell.00058.2009. Epub 2009 Sep 9.

PMID:
19741200
[PubMed - indexed for MEDLINE]
Free Article
3.

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.

Chitale D, Gong Y, Taylor BS, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Seshan VE, Zakowski MF, Rusch V, Pao W, Gerald W, Ladanyi M.

Oncogene. 2009 Aug 6;28(31):2773-83. doi: 10.1038/onc.2009.135. Epub 2009 Jun 15.

PMID:
19525976
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity.

Lev-Ari S, Starr A, Vexler A, Karaush V, Loew V, Greif J, Fenig E, Aderka D, Ben-Yosef R.

Anticancer Res. 2006 Nov-Dec;26(6B):4423-30.

PMID:
17201164
[PubMed - indexed for MEDLINE]
Free Article
5.

Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells.

Zhang Z, Kobayashi S, Borczuk AC, Leidner RS, Laframboise T, Levine AD, Halmos B.

Carcinogenesis. 2010 Apr;31(4):577-86. doi: 10.1093/carcin/bgq020. Epub 2010 Jan 22.

PMID:
20097731
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Regulation of angiopoietin-1/Tie-2 receptor signaling in endothelial cells by dual-specificity phosphatases 1, 4, and 5.

Echavarria R, Hussain SN.

J Am Heart Assoc. 2013 Dec 5;2(6):e000571. doi: 10.1161/JAHA.113.000571.

PMID:
24308939
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.

Iejima D, Minegishi Y, Takenaka K, Siswanto A, Watanabe M, Huang L, Watanabe T, Tanaka F, Kuroda M, Gotoh N.

Oncogene. 2010 May 27;29(21):3087-99. doi: 10.1038/onc.2010.69. Epub 2010 Mar 15.

PMID:
20228838
[PubMed - indexed for MEDLINE]
8.

Epidermal growth factor receptor and protein kinase C signaling to ERK2: spatiotemporal regulation of ERK2 by dual specificity phosphatases.

Caunt CJ, Rivers CA, Conway-Campbell BL, Norman MR, McArdle CA.

J Biol Chem. 2008 Mar 7;283(10):6241-52. doi: 10.1074/jbc.M706624200. Epub 2008 Jan 3.

PMID:
18178562
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Microtubule disruption and tumor suppression by mitogen-activated protein kinase phosphatase 4.

Liu Y, Lagowski J, Sundholm A, Sundberg A, Kulesz-Martin M.

Cancer Res. 2007 Nov 15;67(22):10711-9.

PMID:
18006813
[PubMed - indexed for MEDLINE]
Free Article
10.

Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.

Brannan JM, Dong W, Prudkin L, Behrens C, Lotan R, Bekele BN, Wistuba I, Johnson FM.

Clin Cancer Res. 2009 Jul 1;15(13):4423-30. doi: 10.1158/1078-0432.CCR-09-0473. Epub 2009 Jun 16.

PMID:
19531623
[PubMed - indexed for MEDLINE]
Free Article
11.

Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression.

Serini S, Trombino S, Oliva F, Piccioni E, Monego G, Resci F, Boninsegna A, Picci N, Ranelletti FO, Calviello G.

Apoptosis. 2008 Sep;13(9):1172-83. doi: 10.1007/s10495-008-0246-1.

PMID:
18679798
[PubMed - indexed for MEDLINE]
12.

Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase.

Takeuchi K, Shin-ya T, Nishio K, Ito F.

FEBS J. 2009 Mar;276(5):1255-65. doi: 10.1111/j.1742-4658.2008.06861.x.

PMID:
19175673
[PubMed - indexed for MEDLINE]
13.

Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.

Gröschl B, Bettstetter M, Giedl C, Woenckhaus M, Edmonston T, Hofstädter F, Dietmaier W.

Int J Cancer. 2013 Apr 1;132(7):1537-46. doi: 10.1002/ijc.27834. Epub 2012 Nov 23.

PMID:
22965873
[PubMed - indexed for MEDLINE]
14.

Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.

Balko JM, Cook RS, Vaught DB, Kuba MG, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, Salter J, Dowsett M, Stemke-Hale K, González-Angulo AM, Mills GB, Pinto JA, Gómez HL, Arteaga CL.

Nat Med. 2012 Jul;18(7):1052-9. doi: 10.1038/nm.2795.

PMID:
22683778
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells.

Waha A, Felsberg J, Hartmann W, von dem Knesebeck A, Mikeska T, Joos S, Wolter M, Koch A, Yan PS, Endl E, Wiestler OD, Reifenberger G, Pietsch T, Waha A.

Cancer Res. 2010 Feb 15;70(4):1689-99. doi: 10.1158/0008-5472.CAN-09-3218. Epub 2010 Feb 2.

PMID:
20124482
[PubMed - indexed for MEDLINE]
Free Article
16.

Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition.

Cagnol S, Rivard N.

Oncogene. 2013 Jan 31;32(5):564-76. doi: 10.1038/onc.2012.88. Epub 2012 Mar 19.

PMID:
22430215
[PubMed - indexed for MEDLINE]
17.

Spatiotemporal regulation of ERK2 by dual specificity phosphatases.

Caunt CJ, Armstrong SP, Rivers CA, Norman MR, McArdle CA.

J Biol Chem. 2008 Sep 26;283(39):26612-23. doi: 10.1074/jbc.M801500200. Epub 2008 Jul 23.

PMID:
18650424
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3.

Gómez AR, López-Varea A, Molnar C, de la Calle-Mustienes E, Ruiz-Gómez M, Gómez-Skarmeta JL, de Celis JF.

Dev Dyn. 2005 Mar;232(3):695-708.

PMID:
15704110
[PubMed - indexed for MEDLINE]
Free Article
19.

EGFR mutation up-regulates EGR1 expression through the ERK pathway.

Maegawa M, Arao T, Yokote H, Matsumoto K, Kudo K, Tanaka K, Kaneda H, Fujita Y, Ito F, Nishio K.

Anticancer Res. 2009 Apr;29(4):1111-7.

PMID:
19414352
[PubMed - indexed for MEDLINE]
Free Article
20.

DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs.

Patterson KI, Brummer T, Daly RJ, O'Brien PM.

Biochim Biophys Acta. 2010 Sep;1803(9):1003-12. doi: 10.1016/j.bbamcr.2010.03.014. Epub 2010 Mar 27.

PMID:
20347885
[PubMed - indexed for MEDLINE]
Free Article

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