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Items: 1 to 20 of 138

1.

Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities.

Wilson S, Hashamiyan S, Clarke L, Saftig P, Mort J, Dejica VM, Brömme D.

Am J Pathol. 2009 Nov;175(5):2053-62. doi: 10.2353/ajpath.2009.090211. Epub 2009 Oct 15.

2.

Potential role of cathepsin K in the pathophysiology of mucopolysaccharidoses.

Wilson S, Brömme D.

J Pediatr Rehabil Med. 2010;3(2):139-46. doi: 10.3233/PRM-2010-0116.

3.
4.

Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption.

Wilson SR, Peters C, Saftig P, Brömme D.

J Biol Chem. 2009 Jan 23;284(4):2584-92. doi: 10.1074/jbc.M805280200. Epub 2008 Nov 21.

5.

Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio.

Kiviranta R, Morko J, Alatalo SL, NicAmhlaoibh R, Risteli J, Laitala-Leinonen T, Vuorio E.

Bone. 2005 Jan;36(1):159-72. Epub 2004 Nov 24.

PMID:
15664014
6.

Osteoclastic bone degradation and the role of different cysteine proteinases and matrix metalloproteinases: differences between calvaria and long bone.

Everts V, Korper W, Hoeben KA, Jansen ID, Bromme D, Cleutjens KB, Heeneman S, Peters C, Reinheckel T, Saftig P, Beertsen W.

J Bone Miner Res. 2006 Sep;21(9):1399-408.

7.

Effects of osteoprotegerin administration on osteoclast differentiation and trabecular bone structure in osteoprotegerin-deficient mice.

Yamazaki H, Sasaki T.

J Electron Microsc (Tokyo). 2005 Oct;54(5):467-77. Epub 2005 Dec 9.

PMID:
16339792
8.

The effect of cathepsin K deficiency on airway development and TGF-β1 degradation.

Zhang D, Leung N, Weber E, Saftig P, Brömme D.

Respir Res. 2011 May 31;12:72. doi: 10.1186/1465-9921-12-72.

9.

Assessment of bone dysplasia by micro-CT and glycosaminoglycan levels in mouse models for mucopolysaccharidosis type I, IIIA, IVA, and VII.

Rowan DJ, Tomatsu S, Grubb JH, Montaño AM, Sly WS.

J Inherit Metab Dis. 2013 Mar;36(2):235-46. doi: 10.1007/s10545-012-9522-x. Epub 2012 Sep 13.

10.

Abnormal osteoclast morphology and bone remodeling in a murine model of a lysosomal storage disease.

Monroy MA, Ross FP, Teitelbaum SL, Sands MS.

Bone. 2002 Feb;30(2):352-9.

PMID:
11856642
11.

Regulation of collagenase activities of human cathepsins by glycosaminoglycans.

Li Z, Yasuda Y, Li W, Bogyo M, Katz N, Gordon RE, Fields GB, Brömme D.

J Biol Chem. 2004 Feb 13;279(7):5470-9. Epub 2003 Nov 26.

12.

Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts.

Kneissel M, Luong-Nguyen NH, Baptist M, Cortesi R, Zumstein-Mecker S, Kossida S, O'Reilly T, Lane H, Susa M.

Bone. 2004 Nov;35(5):1144-56.

PMID:
15542040
13.

The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.

Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T.

J Exp Med. 2010 Apr 12;207(4):751-62. doi: 10.1084/jem.20091957. Epub 2010 Apr 5.

14.

Degradation of the organic phase of bone by osteoclasts: a secondary role for lysosomal acidification.

Henriksen K, Sørensen MG, Nielsen RH, Gram J, Schaller S, Dziegiel MH, Everts V, Bollerslev J, Karsdal MA.

J Bone Miner Res. 2006 Jan;21(1):58-66. Epub 2005 Sep 6.

15.

Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro.

Morko J, Kiviranta R, Mulari MT, Ivaska KK, Väänänen HK, Vuorio E, Laitala-Leinonen T.

Bone. 2009 Apr;44(4):717-28. doi: 10.1016/j.bone.2008.11.019. Epub 2008 Dec 11.

PMID:
19118660
16.

Proteolytic processing and polarized secretion of tartrate-resistant acid phosphatase is altered in a subpopulation of metaphyseal osteoclasts in cathepsin K-deficient mice.

Zenger S, Hollberg K, Ljusberg J, Norgård M, Ek-Rylander B, Kiviranta R, Andersson G.

Bone. 2007 Nov;41(5):820-32. Epub 2007 Jul 19.

PMID:
17765026
17.

Does increased local bone resorption secondary to breast and prostate cancer result in increased cartilage degradation?

Leeming DJ, Byrjalsen I, Qvist P, Koizumi M, Lynnerup N, Fregerslev M, Sørensen MG, Christiansen C, Karsdal MA.

BMC Cancer. 2008 Jun 27;8:180. doi: 10.1186/1471-2407-8-180.

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19.

Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones.

Xia L, Kilb J, Wex H, Li Z, Lipyansky A, Breuil V, Stein L, Palmer JT, Dempster DW, Brömme D.

Biol Chem. 1999 Jun;380(6):679-87.

PMID:
10430032
20.

Neonatal retroviral vector-mediated hepatic gene therapy reduces bone, joint, and cartilage disease in mucopolysaccharidosis VII mice and dogs.

Mango RL, Xu L, Sands MS, Vogler C, Seiler G, Schwarz T, Haskins ME, Ponder KP.

Mol Genet Metab. 2004 May;82(1):4-19.

PMID:
15110316
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