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Results: 1 to 20 of 99

1.

Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes.

Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Højlund K, Yi Z, Mandarino LJ.

Diabetes. 2010 Jan;59(1):33-42. doi: 10.2337/db09-0214. Epub 2009 Oct 15.

PMID:
19833877
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes.

Giebelstein J, Poschmann G, Højlund K, Schechinger W, Dietrich JW, Levin K, Beck-Nielsen H, Podwojski K, Stühler K, Meyer HE, Klein HH.

Diabetologia. 2012 Apr;55(4):1114-27. doi: 10.1007/s00125-012-2456-x. Epub 2012 Jan 27. Erratum in: Diabetologia. 2012 Jul;55(7):2083.

PMID:
22282162
[PubMed - indexed for MEDLINE]
3.

Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle.

Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z, De Filippis EA, Brophy C, Meyer C, Højlund K, Yi Z, Mandarino LJ.

Diabetes. 2010 Oct;59(10):2444-52. doi: 10.2337/db10-0174. Epub 2010 Aug 3.

PMID:
20682693
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the disease.

Meyer MM, Levin K, Grimmsmann T, Beck-Nielsen H, Klein HH.

Diabetologia. 2002 Jun;45(6):813-22. Epub 2002 May 8.

PMID:
12107725
[PubMed - indexed for MEDLINE]
5.

Characterization of human myotubes from type 2 diabetic and nondiabetic subjects using complementary quantitative mass spectrometric methods.

Thingholm TE, Bak S, Beck-Nielsen H, Jensen ON, Gaster M.

Mol Cell Proteomics. 2011 Sep;10(9):M110.006650. doi: 10.1074/mcp.M110.006650. Epub 2011 Jun 22.

PMID:
21697546
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

PPAR-gamma gene expression is elevated in skeletal muscle of obese and type II diabetic subjects.

Park KS, Ciaraldi TP, Abrams-Carter L, Mudaliar S, Nikoulina SE, Henry RR.

Diabetes. 1997 Jul;46(7):1230-4.

PMID:
9200661
[PubMed - indexed for MEDLINE]
7.

Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM.

Garvey WT, Maianu L, Hancock JA, Golichowski AM, Baron A.

Diabetes. 1992 Apr;41(4):465-75.

PMID:
1535055
[PubMed - indexed for MEDLINE]
8.

Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.

Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palacín M, Mingrone G, Zierath JR, Vidal H, Zorzano A.

Diabetes. 2005 Sep;54(9):2685-93.

PMID:
16123358
[PubMed - indexed for MEDLINE]
Free Article
9.

Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility.

Chomentowski P, Coen PM, Radiková Z, Goodpaster BH, Toledo FG.

J Clin Endocrinol Metab. 2011 Feb;96(2):494-503. doi: 10.1210/jc.2010-0822. Epub 2010 Nov 24.

PMID:
21106709
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants.

Abdul-Ghani MA, Jani R, Chavez A, Molina-Carrion M, Tripathy D, Defronzo RA.

Diabetologia. 2009 Apr;52(4):574-82. doi: 10.1007/s00125-009-1264-4. Epub 2009 Jan 30.

PMID:
19183935
[PubMed - indexed for MEDLINE]
11.

Proteomic analysis of tumor necrosis factor-alpha (TNF-α)-induced L6 myotube secretome reveals novel TNF-α-dependent myokines in diabetic skeletal muscle.

Yoon JH, Song P, Jang JH, Kim DK, Choi S, Kim J, Ghim J, Kim D, Park S, Lee H, Kwak D, Yea K, Hwang D, Suh PG, Ryu SH.

J Proteome Res. 2011 Dec 2;10(12):5315-25. doi: 10.1021/pr200573b. Epub 2011 Nov 11.

PMID:
22023146
[PubMed - indexed for MEDLINE]
12.

FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.

Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J.

Diabetes. 2011 Jan;60(1):258-68. doi: 10.2337/db10-0281. Epub 2010 Oct 13.

PMID:
20943749
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.

Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D.

Diabetes Care. 2009 Aug;32(8):1542-6. doi: 10.2337/dc09-0684. Epub 2009 Jun 1.

PMID:
19487637
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes.

Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE.

Diabetes. 2005 Jan;54(1):8-14.

PMID:
15616005
[PubMed - indexed for MEDLINE]
Free Article
15.

Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia.

Asmann YW, Stump CS, Short KR, Coenen-Schimke JM, Guo Z, Bigelow ML, Nair KS.

Diabetes. 2006 Dec;55(12):3309-19.

PMID:
17130474
[PubMed - indexed for MEDLINE]
Free Article
16.

Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus.

Mensink M, Hesselink MK, Russell AP, Schaart G, Sels JP, Schrauwen P.

Int J Obes (Lond). 2007 Aug;31(8):1302-10. Epub 2007 Feb 20.

PMID:
17310221
[PubMed - indexed for MEDLINE]
17.

Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome.

Skov V, Glintborg D, Knudsen S, Jensen T, Kruse TA, Tan Q, Brusgaard K, Beck-Nielsen H, Højlund K.

Diabetes. 2007 Sep;56(9):2349-55. Epub 2007 Jun 11.

PMID:
17563058
[PubMed - indexed for MEDLINE]
Free Article
18.

Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function.

Karakelides H, Irving BA, Short KR, O'Brien P, Nair KS.

Diabetes. 2010 Jan;59(1):89-97. doi: 10.2337/db09-0591. Epub 2009 Oct 15.

PMID:
19833885
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance.

Hoeks J, van Herpen NA, Mensink M, Moonen-Kornips E, van Beurden D, Hesselink MK, Schrauwen P.

Diabetes. 2010 Sep;59(9):2117-25. doi: 10.2337/db10-0519. Epub 2010 Jun 23.

PMID:
20573749
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance.

Nair KS, Bigelow ML, Asmann YW, Chow LS, Coenen-Schimke JM, Klaus KA, Guo ZK, Sreekumar R, Irving BA.

Diabetes. 2008 May;57(5):1166-75. doi: 10.2337/db07-1556. Epub 2008 Feb 19. Erratum in: Diabetes. 2009 Mar;58(3):770.

PMID:
18285554
[PubMed - indexed for MEDLINE]
Free Article

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