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Items: 1 to 20 of 105


Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis.

Tao GZ, Looi KS, Toivola DM, Strnad P, Zhou Q, Liao J, Wei Y, Habtezion A, Omary MB.

J Cell Sci. 2009 Nov 1;122(Pt 21):3851-5. doi: 10.1242/jcs.051862. Epub 2009 Oct 13.


Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.

Ku NO, Strnad P, Zhong BH, Tao GZ, Omary MB.

Hepatology. 2007 Nov;46(5):1639-49. Review.


Keratins modulate hepatic cell adhesion, size and G1/S transition.

Galarneau L, Loranger A, Gilbert S, Marceau N.

Exp Cell Res. 2007 Jan 1;313(1):179-94. Epub 2006 Oct 13.


Switch in Fas-activated death signaling pathway as result of keratin 8/18-intermediate filament loss.

Gilbert S, Ruel A, Loranger A, Marceau N.

Apoptosis. 2008 Dec;13(12):1479-93. doi: 10.1007/s10495-008-0274-x.


Novel insights into changes in biochemical properties of keratins 8 and 18 in griseofulvin-induced toxic liver injury.

Fortier AM, Riopel K, Désaulniers M, Cadrin M.

Exp Mol Pathol. 2010 Oct;89(2):117-25. doi: 10.1016/j.yexmp.2010.07.004. Epub 2010 Jul 17.


Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation.

Harada M, Strnad P, Resurreccion EZ, Ku NO, Omary MB.

Hepatology. 2007 Jan;45(1):88-96.


Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury.

Tao GZ, Toivola DM, Zhong B, Michie SA, Resurreccion EZ, Tamai Y, Taketo MM, Omary MB.

J Cell Sci. 2003 Nov 15;116(Pt 22):4629-38.


Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.

Toivola DM, Nakamichi I, Strnad P, Michie SA, Ghori N, Harada M, Zeh K, Oshima RG, Baribault H, Omary MB.

Am J Pathol. 2008 Apr;172(4):882-92. doi: 10.2353/ajpath.2008.070830. Epub 2008 Mar 18.


Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity.

Weerasinghe SV, Ku NO, Altshuler PJ, Kwan R, Omary MB.

J Cell Sci. 2014 Apr 1;127(Pt 7):1464-75. doi: 10.1242/jcs.138479. Epub 2014 Jan 24.


Cytoskeletal keratin glycosylation protects epithelial tissue from injury.

Ku NO, Toivola DM, Strnad P, Omary MB.

Nat Cell Biol. 2010 Sep;12(9):876-85. doi: 10.1038/ncb2091. Epub 2010 Aug 22.


Cytoskeleton keratin regulation of FasR signaling through modulation of actin/ezrin interplay at lipid rafts in hepatocytes.

Gilbert S, Loranger A, Lavoie JN, Marceau N.

Apoptosis. 2012 Aug;17(8):880-94. doi: 10.1007/s10495-012-0733-2.


Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.

Haybaeck J, Stumptner C, Thueringer A, Kolbe T, Magin TM, Hesse M, Fickert P, Tsybrovskyy O, Müller H, Trauner M, Zatloukal K, Denk H.

Lab Invest. 2012 Jun;92(6):857-67. doi: 10.1038/labinvest.2012.49. Epub 2012 Mar 26.


Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity.

Zhong B, Strnad P, Selmi C, Invernizzi P, Tao GZ, Caleffi A, Chen M, Bianchi I, Podda M, Pietrangelo A, Gershwin ME, Omary MB.

Hepatology. 2009 Aug;50(2):546-54. doi: 10.1002/hep.23041.


Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling.

Mathew J, Loranger A, Gilbert S, Faure R, Marceau N.

Exp Cell Res. 2013 Feb 15;319(4):474-86. doi: 10.1016/j.yexcr.2012.11.011. Epub 2012 Nov 17.


Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.

Strnad P, Tao GZ, Zhou Q, Harada M, Toivola DM, Brunt EM, Omary MB.

Gastroenterology. 2008 Apr;134(4):1169-79. doi: 10.1053/j.gastro.2008.01.035. Epub 2008 Jan 18.


Keratin 8/18 modulation of protein kinase C-mediated integrin-dependent adhesion and migration of liver epithelial cells.

Bordeleau F, Galarneau L, Gilbert S, Loranger A, Marceau N.

Mol Biol Cell. 2010 May 15;21(10):1698-713. doi: 10.1091/mbc.E09-05-0373. Epub 2010 Mar 31.


The Pirh2-keratin 8/18 interaction modulates the cellular distribution of mitochondria and UV-induced apoptosis.

Duan S, Yao Z, Zhu Y, Wang G, Hou D, Wen L, Wu M.

Cell Death Differ. 2009 Jun;16(6):826-37. doi: 10.1038/cdd.2009.12. Epub 2009 Mar 13.


Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.

Snider NT, Weerasinghe SV, Iñiguez-Lluhí JA, Herrmann H, Omary MB.

J Biol Chem. 2011 Jan 21;286(3):2273-84. doi: 10.1074/jbc.M110.171314. Epub 2010 Nov 9.

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