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Items: 1 to 20 of 210

1.

CHO gene expression profiling in biopharmaceutical process analysis and design.

Schaub J, Clemens C, Schorn P, Hildebrandt T, Rust W, Mennerich D, Kaufmann H, Schulz TW.

Biotechnol Bioeng. 2010 Feb 1;105(2):431-8. doi: 10.1002/bit.22549.

PMID:
19777598
2.

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism.

Ma N, Ellet J, Okediadi C, Hermes P, McCormick E, Casnocha S.

Biotechnol Prog. 2009 Sep-Oct;25(5):1353-63. doi: 10.1002/btpr.238.

PMID:
19637321
3.

Conversion of a CHO cell culture process from perfusion to fed-batch technology without altering product quality.

Meuwly F, Weber U, Ziegler T, Gervais A, Mastrangeli R, Crisci C, Rossi M, Bernard A, von Stockar U, Kadouri A.

J Biotechnol. 2006 May 3;123(1):106-16. Epub 2005 Dec 1.

PMID:
16324762
4.

Process parameter shifting: Part II. Biphasic cultivation-A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells.

Trummer E, Fauland K, Seidinger S, Schriebl K, Lattenmayer C, Kunert R, Vorauer-Uhl K, Weik R, Borth N, Katinger H, Müller D.

Biotechnol Bioeng. 2006 Aug 20;94(6):1045-52.

PMID:
16736532
5.
6.

An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes.

Becker E, Florin L, Pfizenmaier K, Kaufmann H.

J Biotechnol. 2008 Jun 1;135(2):217-23. doi: 10.1016/j.jbiotec.2008.03.008. Epub 2008 Mar 28.

PMID:
18448183
7.

Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures.

Amanullah A, Otero JM, Mikola M, Hsu A, Zhang J, Aunins J, Schreyer HB, Hope JA, Russo AP.

Biotechnol Bioeng. 2010 May 1;106(1):57-67. doi: 10.1002/bit.22664.

PMID:
20073088
8.

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment.

Huang YM, Hu W, Rustandi E, Chang K, Yusuf-Makagiansar H, Ryll T.

Biotechnol Prog. 2010 Sep-Oct;26(5):1400-10. doi: 10.1002/btpr.436.

PMID:
20945494
9.

CHO cells in biotechnology for production of recombinant proteins: current state and further potential.

Kim JY, Kim YG, Lee GM.

Appl Microbiol Biotechnol. 2012 Feb;93(3):917-30. doi: 10.1007/s00253-011-3758-5. Epub 2011 Dec 9. Review.

PMID:
22159888
10.

The "push-to-low" approach for optimization of high-density perfusion cultures of animal cells.

Konstantinov K, Goudar C, Ng M, Meneses R, Thrift J, Chuppa S, Matanguihan C, Michaels J, Naveh D.

Adv Biochem Eng Biotechnol. 2006;101:75-98.

PMID:
16989258
11.

Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors.

Trummer E, Fauland K, Seidinger S, Schriebl K, Lattenmayer C, Kunert R, Vorauer-Uhl K, Weik R, Borth N, Katinger H, Müller D.

Biotechnol Bioeng. 2006 Aug 20;94(6):1033-44.

PMID:
16736530
12.

Microarray-based gene expression analysis as a process characterization tool to establish comparability of complex biological products: scale-up of a whole-cell immunotherapy product.

Wang M, Senger RS, Paredes C, Banik GG, Lin A, Papoutsakis ET.

Biotechnol Bioeng. 2009 Nov 1;104(4):796-808. doi: 10.1002/bit.22441.

PMID:
19591186
13.

Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling.

Deshpande R, Yang TH, Heinzle E.

Biotechnol J. 2009 Feb;4(2):247-63. doi: 10.1002/biot.200800143.

PMID:
19194975
14.

An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer.

McLeod J, O'Callaghan PM, Pybus LP, Wilkinson SJ, Root T, Racher AJ, James DC.

Biotechnol Bioeng. 2011 Sep;108(9):2193-204. doi: 10.1002/bit.23146. Epub 2011 Apr 27.

PMID:
21445882
15.

Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells.

Gammell P, Barron N, Kumar N, Clynes M.

J Biotechnol. 2007 Jun 30;130(3):213-8. Epub 2007 Apr 29.

PMID:
17570552
16.

Bioprocess development for the production of a recombinant MUC1 fusion protein expressed by CHO-K1 cells in protein-free medium.

Link T, Bäckström M, Graham R, Essers R, Zörner K, Gätgens J, Burchell J, Taylor-Papadimitriou J, Hansson GC, Noll T.

J Biotechnol. 2004 May 13;110(1):51-62.

PMID:
15099905
17.

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation.

Fan Y, Jimenez Del Val I, Müller C, Wagtberg Sen J, Rasmussen SK, Kontoravdi C, Weilguny D, Andersen MR.

Biotechnol Bioeng. 2015 Mar;112(3):521-35. doi: 10.1002/bit.25450. Epub 2014 Oct 10.

PMID:
25220616
18.

Improving performance of mammalian cells in fed-batch processes through "bioreactor evolution".

Prentice HL, Ehrenfels BN, Sisk WP.

Biotechnol Prog. 2007 Mar-Apr;23(2):458-64. Epub 2007 Feb 21.

PMID:
17311405
19.

Influence of intracellular nucleotide and nucleotide sugar contents on recombinant interferon-gamma glycosylation during batch and fed-batch cultures of CHO cells.

Kochanowski N, Blanchard F, Cacan R, Chirat F, Guedon E, Marc A, Goergen JL.

Biotechnol Bioeng. 2008 Jul 1;100(4):721-33. doi: 10.1002/bit.21816.

PMID:
18496872
20.

Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures.

Chee Furng Wong D, Tin Kam Wong K, Tang Goh L, Kiat Heng C, Gek Sim Yap M.

Biotechnol Bioeng. 2005 Jan 20;89(2):164-77.

PMID:
15593097
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