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Items: 1 to 20 of 78

1.

Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.

Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW.

Nat Med. 2009 Oct;15(10):1186-94. doi: 10.1038/nm.2029. Epub 2009 Sep 20.

2.

The KCNQ1-KCNE2 K⁺ channel is required for adequate thyroid I⁻ uptake.

Purtell K, Paroder-Belenitsky M, Reyna-Neyra A, Nicola JP, Koba W, Fine E, Carrasco N, Abbott GW.

FASEB J. 2012 Aug;26(8):3252-9. doi: 10.1096/fj.12-206110. Epub 2012 May 1.

3.

Cardiac arrhythmia and thyroid dysfunction: a novel genetic link.

Purtell K, Roepke TK, Abbott GW.

Int J Biochem Cell Biol. 2010 Nov;42(11):1767-70. doi: 10.1016/j.biocel.2010.07.013. Epub 2010 Aug 3. Review.

4.

KCNE2 and the K (+) channel: the tail wagging the dog.

Abbott GW.

Channels (Austin). 2012 Jan-Feb;6(1):1-10. doi: 10.4161/chan.19126. Epub 2012 Jan 1. Review.

5.

KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium.

Roepke TK, Kanda VA, Purtell K, King EC, Lerner DJ, Abbott GW.

FASEB J. 2011 Dec;25(12):4264-73. doi: 10.1096/fj.11-187609. Epub 2011 Aug 22.

6.

Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death.

Hu Z, Kant R, Anand M, King EC, Krogh-Madsen T, Christini DJ, Abbott GW.

Circ Cardiovasc Genet. 2014 Feb;7(1):33-42. doi: 10.1161/CIRCGENETICS.113.000315. Epub 2014 Jan 8.

7.

The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion.

Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW.

J Biol Chem. 2006 Aug 18;281(33):23740-7. Epub 2006 Jun 5.

8.

The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology.

Abbott GW.

Gene. 2015 Sep 15;569(2):162-72. doi: 10.1016/j.gene.2015.06.061. Epub 2015 Jun 27. Review.

PMID:
26123744
9.

Prolactin and growth hormone stimulation of lactation in mice requires thyroid hormones.

Capuco AV, Kahl S, Jack LJ, Bishop JO, Wallace H.

Proc Soc Exp Biol Med. 1999 Sep;221(4):345-51.

PMID:
10460696
10.

KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart.

Wu DM, Jiang M, Zhang M, Liu XS, Korolkova YV, Tseng GN.

Heart Rhythm. 2006 Dec;3(12):1469-80. Epub 2006 Aug 25.

PMID:
17161791
11.

Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).

Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW.

FASEB J. 2008 Oct;22(10):3648-60. doi: 10.1096/fj.08-110171. Epub 2008 Jul 4.

12.

Hypothyroidism of gene-targeted mice lacking Kcnq1.

Fröhlich H, Boini KM, Seebohm G, Strutz-Seebohm N, Ureche ON, Föller M, Eichenmüller M, Shumilina E, Pathare G, Singh AK, Seidler U, Pfeifer KE, Lang F.

Pflugers Arch. 2011 Jan;461(1):45-52. doi: 10.1007/s00424-010-0890-5. Epub 2010 Oct 27.

13.

Impaired local deiodination of thyroxine to triiodothyronine in dogs with symmetrical truncal alopecia.

Rudas P, Bartha T, Toth J, Frenyo VL.

Vet Res Commun. 1994;18(3):175-82.

PMID:
7985379
14.

Cortactin is required for N-cadherin regulation of Kv1.5 channel function.

Cheng L, Yung A, Covarrubias M, Radice GL.

J Biol Chem. 2011 Jun 10;286(23):20478-89. doi: 10.1074/jbc.M111.218560. Epub 2011 Apr 20.

15.

Molecular genetics of congenital hypothyroidism.

Macchia PE, De Felice M, Di Lauro R.

Curr Opin Genet Dev. 1999 Jun;9(3):289-94. Review.

PMID:
10377281
16.

Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle.

Nishiyama A, Kambe F, Kamiya K, Seo H, Toyama J.

Cardiovasc Res. 1998 Nov;40(2):343-51.

17.

Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.

Salsbury G, Cambridge EL, McIntyre Z, Arends MJ, Karp NA, Isherwood C, Shannon C, Hooks Y; Sanger Mouse Genetics Project, Ramirez-Solis R, Adams DJ, White JK, Speak AO.

Exp Hematol. 2014 Dec;42(12):1053-8.e1. doi: 10.1016/j.exphem.2014.07.269. Epub 2014 Aug 12. Erratum in: Exp Hematol. 2015 May;43(5):424.

18.

Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation.

Yang Y, Xia M, Jin Q, Bendahhou S, Shi J, Chen Y, Liang B, Lin J, Liu Y, Liu B, Zhou Q, Zhang D, Wang R, Ma N, Su X, Niu K, Pei Y, Xu W, Chen Z, Wan H, Cui J, Barhanin J, Chen Y.

Am J Hum Genet. 2004 Nov;75(5):899-905. Epub 2004 Sep 13.

19.

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel.

Tinel N, Diochot S, Borsotto M, Lazdunski M, Barhanin J.

EMBO J. 2000 Dec 1;19(23):6326-30.

20.

Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells.

Freitas BC, Gereben B, Castillo M, Kalló I, Zeöld A, Egri P, Liposits Z, Zavacki AM, Maciel RM, Jo S, Singru P, Sanchez E, Lechan RM, Bianco AC.

J Clin Invest. 2010 Jun;120(6):2206-17. doi: 10.1172/JCI41977. Epub 2010 May 10.

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