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Results: 1 to 20 of 100

1.

An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.

Salahudeen AA, Thompson JW, Ruiz JC, Ma HW, Kinch LN, Li Q, Grishin NV, Bruick RK.

Science. 2009 Oct 30;326(5953):722-6. doi: 10.1126/science.1176326. Epub 2009 Sep 17.

PMID:
19762597
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Control of iron homeostasis by an iron-regulated ubiquitin ligase.

Vashisht AA, Zumbrennen KB, Huang X, Powers DN, Durazo A, Sun D, Bhaskaran N, Persson A, Uhlen M, Sangfelt O, Spruck C, Leibold EA, Wohlschlegel JA.

Science. 2009 Oct 30;326(5953):718-21. doi: 10.1126/science.1176333. Epub 2009 Sep 17.

PMID:
19762596
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.

Chollangi S, Thompson JW, Ruiz JC, Gardner KH, Bruick RK.

J Biol Chem. 2012 Jul 6;287(28):23710-7. doi: 10.1074/jbc.M112.360404. Epub 2012 May 30.

PMID:
22648410
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).

Thompson JW, Salahudeen AA, Chollangi S, Ruiz JC, Brautigam CA, Makris TM, Lipscomb JD, Tomchick DR, Bruick RK.

J Biol Chem. 2012 Mar 2;287(10):7357-65. doi: 10.1074/jbc.M111.308684. Epub 2012 Jan 17.

PMID:
22253436
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.

Ruiz JC, Walker SD, Anderson SA, Eisenstein RS, Bruick RK.

J Biol Chem. 2013 Jan 4;288(1):552-60. doi: 10.1074/jbc.M112.426171. Epub 2012 Nov 7.

PMID:
23135277
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Cell biology. An ancient gauge for iron.

Rouault TA.

Science. 2009 Oct 30;326(5953):676-7. doi: 10.1126/science.1181938. No abstract available.

PMID:
19900922
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells.

Zumbrennen KB, Hanson ES, Leibold EA.

Biochim Biophys Acta. 2008 Feb;1783(2):246-52. Epub 2007 Aug 9.

PMID:
17822790
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.

Moroishi T, Yamauchi T, Nishiyama M, Nakayama KI.

J Biol Chem. 2014 Jun 6;289(23):16430-41. doi: 10.1074/jbc.M113.541490. Epub 2014 Apr 28.

PMID:
24778179
[PubMed - in process]
9.

Redox control of iron regulatory protein 2 stability.

Hausmann A, Lee J, Pantopoulos K.

FEBS Lett. 2011 Feb 18;585(4):687-92. doi: 10.1016/j.febslet.2011.01.036. Epub 2011 Feb 1.

PMID:
21281640
[PubMed - indexed for MEDLINE]
Free Article
10.

F-box and leucine-rich repeat protein 5 (FBXL5): sensing intracellular iron and oxygen.

Ruiz JC, Bruick RK.

J Inorg Biochem. 2014 Apr;133:73-7. doi: 10.1016/j.jinorgbio.2014.01.015. Epub 2014 Jan 25.

PMID:
24508277
[PubMed - in process]
11.

Iron regulatory protein 2 turnover through a nonproteasomal pathway.

Chang AH, Jeong J, Levine RL.

J Biol Chem. 2011 Jul 8;286(27):23698-707. doi: 10.1074/jbc.M110.216788. Epub 2011 May 10.

PMID:
21558272
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL.

Wang J, Pantopoulos K.

Biochim Biophys Acta. 2005 Mar 22;1743(1-2):79-85.

PMID:
15777842
[PubMed - indexed for MEDLINE]
Free Article
13.

Oxygen and iron regulation of iron regulatory protein 2.

Hanson ES, Rawlins ML, Leibold EA.

J Biol Chem. 2003 Oct 10;278(41):40337-42. Epub 2003 Jul 29.

PMID:
12888568
[PubMed - indexed for MEDLINE]
Free Article
14.

The structural basis of iron sensing by the human F-box protein FBXL5.

Shu C, Sung MW, Stewart MD, Igumenova TI, Tan X, Li P.

Chembiochem. 2012 Apr 16;13(6):788-91. doi: 10.1002/cbic.201200043. No abstract available.

PMID:
22492618
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Protein degradation and iron homeostasis.

Thompson JW, Bruick RK.

Biochim Biophys Acta. 2012 Sep;1823(9):1484-90. doi: 10.1016/j.bbamcr.2012.02.003. Epub 2012 Feb 10. Review.

PMID:
22349011
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

A role for lysosomes in the turnover of human iron regulatory protein 2.

Dycke C, Charbonnier P, Pantopoulos K, Moulis JM.

Int J Biochem Cell Biol. 2008;40(12):2826-32. doi: 10.1016/j.biocel.2008.05.015. Epub 2008 Jun 5.

PMID:
18582596
[PubMed - indexed for MEDLINE]
17.

Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.

Schneider BD, Leibold EA.

Blood. 2003 Nov 1;102(9):3404-11. Epub 2003 Jul 10.

PMID:
12855587
[PubMed - indexed for MEDLINE]
Free Article
18.

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.

Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K.

Nat Cell Biol. 2003 Apr;5(4):336-40.

PMID:
12629548
[PubMed - indexed for MEDLINE]
19.

Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity.

Wang J, Chen G, Lee J, Pantopoulos K.

BMC Mol Biol. 2008 Jan 28;9:15. doi: 10.1186/1471-2199-9-15.

PMID:
18226225
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.

Bourdon E, Kang DK, Ghosh MC, Drake SK, Wey J, Levine RL, Rouault TA.

Blood Cells Mol Dis. 2003 Sep-Oct;31(2):247-55.

PMID:
12972033
[PubMed - indexed for MEDLINE]

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