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Results: 1 to 20 of 102

1.

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.

Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA.

N Engl J Med. 2009 Sep 17;361(12):1173-8. doi: 10.1056/NEJMoa0902903. Epub 2009 Sep 2.

PMID:
19726761
[PubMed - indexed for MEDLINE]
Free Article
2.

PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition.

Metcalfe C, Alicke B, Crow A, Lamoureux M, Dijkgraaf GJ, Peale F, Gould SE, de Sauvage FJ.

Cancer Res. 2013 Dec 1;73(23):7034-42. doi: 10.1158/0008-5472.CAN-13-1222. Epub 2013 Oct 23.

PMID:
24154871
[PubMed - indexed for MEDLINE]
3.

Hedgehog pathway inhibition and the race against tumor evolution.

Atwood SX, Chang AL, Oro AE.

J Cell Biol. 2012 Oct 15;199(2):193-7. doi: 10.1083/jcb.201207140.

PMID:
23071148
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.

PMID:
23762360
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.

Von Hoff DD, LoRusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Mackey HM, Lum BL, Darbonne WC, Marsters JC Jr, de Sauvage FJ, Low JA.

N Engl J Med. 2009 Sep 17;361(12):1164-72. doi: 10.1056/NEJMoa0905360. Epub 2009 Sep 2.

PMID:
19726763
[PubMed - indexed for MEDLINE]
Free Article
6.

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ.

Science. 2009 Oct 23;326(5952):572-4. doi: 10.1126/science.1179386. Epub 2009 Sep 2.

PMID:
19726788
[PubMed - indexed for MEDLINE]
Free Article
7.

Clinical experience with Hedgehog pathway inhibitors.

Low JA, de Sauvage FJ.

J Clin Oncol. 2010 Dec 20;28(36):5321-6. doi: 10.1200/JCO.2010.27.9943. Epub 2010 Nov 1.

PMID:
21041712
[PubMed - indexed for MEDLINE]
8.

GDC-0449-a potent inhibitor of the hedgehog pathway.

Robarge KD, Brunton SA, Castanedo GM, Cui Y, Dina MS, Goldsmith R, Gould SE, Guichert O, Gunzner JL, Halladay J, Jia W, Khojasteh C, Koehler MF, Kotkow K, La H, Lalonde RL, Lau K, Lee L, Marshall D, Marsters JC Jr, Murray LJ, Qian C, Rubin LL, Salphati L, Stanley MS, Stibbard JH, Sutherlin DP, Ubhayaker S, Wang S, Wong S, Xie M.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5576-81. doi: 10.1016/j.bmcl.2009.08.049. Epub 2009 Aug 15. Erratum in: Bioorg Med Chem Lett. 2010 Jan 15;20(2):771.

PMID:
19716296
[PubMed - indexed for MEDLINE]
9.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

PMID:
24094913
[PubMed - indexed for MEDLINE]
10.

Clinical implications of hedgehog signaling pathway inhibitors.

Liu H, Gu D, Xie J.

Chin J Cancer. 2011 Jan;30(1):13-26. Review.

PMID:
21192841
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

LoRusso PM, Rudin CM, Reddy JC, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Chang I, Darbonne WC, Graham RA, Zerivitz KL, Low JA, Von Hoff DD.

Clin Cancer Res. 2011 Apr 15;17(8):2502-11. doi: 10.1158/1078-0432.CCR-10-2745. Epub 2011 Feb 7.

PMID:
21300762
[PubMed - indexed for MEDLINE]
Free Article
12.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

PMID:
21143927
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells.

Elamin MH, Shinwari Z, Hendrayani SF, Al-Hindi H, Al-Shail E, Khafaga Y, Al-Kofide A, Aboussekhra A.

Mol Carcinog. 2010 Mar;49(3):302-14. doi: 10.1002/mc.20604.

PMID:
20025076
[PubMed - indexed for MEDLINE]
14.

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.

Dijkgraaf GJ, Alicke B, Weinmann L, Januario T, West K, Modrusan Z, Burdick D, Goldsmith R, Robarge K, Sutherlin D, Scales SJ, Gould SE, Yauch RL, de Sauvage FJ.

Cancer Res. 2011 Jan 15;71(2):435-44. doi: 10.1158/0008-5472.CAN-10-2876. Epub 2010 Dec 1.

PMID:
21123452
[PubMed - indexed for MEDLINE]
Free Article
15.

Medulloblastoma growth inhibition by hedgehog pathway blockade.

Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA.

Science. 2002 Aug 30;297(5586):1559-61.

PMID:
12202832
[PubMed - indexed for MEDLINE]
Free Article
16.

Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b.

Karlou M, Lu JF, Wu G, Maity S, Tzelepi V, Navone NM, Hoang A, Logothetis CJ, Efstathiou E.

Prostate. 2012 Nov;72(15):1638-47. doi: 10.1002/pros.22517. Epub 2012 Mar 27.

PMID:
22457212
[PubMed - indexed for MEDLINE]
17.

Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation.

Wong H, Alicke B, West KA, Pacheco P, La H, Januario T, Yauch RL, de Sauvage FJ, Gould SE.

Clin Cancer Res. 2011 Jul 15;17(14):4682-92. doi: 10.1158/1078-0432.CCR-11-0975. Epub 2011 May 24.

PMID:
21610148
[PubMed - indexed for MEDLINE]
Free Article
18.

Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.

Bahra M, Kamphues C, Boas-Knoop S, Lippert S, Esendik U, Schüller U, Hartmann W, Waha A, Neuhaus P, Heppner F, Pietsch T, Koch A.

Pancreas. 2012 Mar;41(2):222-9. doi: 10.1097/MPA.0b013e31822896dd.

PMID:
22076568
[PubMed - indexed for MEDLINE]
19.

Medulloblastoma stem cells.

Fan X, Eberhart CG.

J Clin Oncol. 2008 Jun 10;26(17):2821-7. doi: 10.1200/JCO.2007.15.2264. Review.

PMID:
18539960
[PubMed - indexed for MEDLINE]
20.

Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists.

Metcalfe C, de Sauvage FJ.

Cancer Res. 2011 Aug 1;71(15):5057-61. doi: 10.1158/0008-5472.CAN-11-0923. Epub 2011 Jul 19. Review. Erratum in: Cancer Res. 2011 Sep 15;71(18):6087.

PMID:
21771911
[PubMed - indexed for MEDLINE]
Free Article

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