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Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.

Ruzankina Y, Schoppy DW, Asare A, Clark CE, Vonderheide RH, Brown EJ.

Nat Genet. 2009 Oct;41(10):1144-9. doi: 10.1038/ng.441. Epub 2009 Aug 30.


Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.

Gilad O, Nabet BY, Ragland RL, Schoppy DW, Smith KD, Durham AC, Brown EJ.

Cancer Res. 2010 Dec 1;70(23):9693-702. doi: 10.1158/0008-5472.CAN-10-2286. Epub 2010 Nov 23.


Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

Ruzankina Y, Pinzon-Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, Zediak VP, Velez M, Bhandoola A, Brown EJ.

Cell Stem Cell. 2007 Jun 7;1(1):113-26. doi: 10.1016/j.stem.2007.03.002.


Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.

Balmus G, Zhu M, Mukherjee S, Lyndaker AM, Hume KR, Lee J, Riccio ML, Reeves AP, Sutter NB, Noden DM, Peters RM, Weiss RS.

Hum Mol Genet. 2012 Aug 1;21(15):3408-20. doi: 10.1093/hmg/dds173. Epub 2012 May 9.


Trp53 deficiency protects against acute intestinal inflammation.

Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.

J Immunol. 2013 Jul 15;191(2):837-47. doi: 10.4049/jimmunol.1201716. Epub 2013 Jun 14.


Removing all obstacles: a critical role for p53 in promoting tissue renewal.

Schoppy DW, Ruzankina Y, Brown EJ.

Cell Cycle. 2010 Apr 1;9(7):1313-9. Epub 2010 Apr 1. Review.


A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.

Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O.

Nat Genet. 2009 Aug;41(8):891-8. doi: 10.1038/ng.420. Epub 2009 Jul 20.


ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.

Pabla N, Huang S, Mi QS, Daniel R, Dong Z.

J Biol Chem. 2008 Mar 7;283(10):6572-83. Epub 2007 Dec 27. Erratum in: J Biol Chem. 2008 May 30;283(22):15512.


HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage.

Wallace NA, Robinson K, Howie HL, Galloway DA.

PLoS Pathog. 2012;8(7):e1002807. doi: 10.1371/journal.ppat.1002807. Epub 2012 Jul 12.


Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex.

McConnell MJ, Kaushal D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C.

J Neurosci. 2004 Sep 15;24(37):8090-6.


hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis.

Pabla N, Ma Z, McIlhatton MA, Fishel R, Dong Z.

J Biol Chem. 2011 Mar 25;286(12):10411-8. doi: 10.1074/jbc.M110.210989. Epub 2011 Feb 1.


Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration.

Yazinski SA, Westcott PM, Ong K, Pinkas J, Peters RM, Weiss RS.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21282-7. doi: 10.1073/pnas.0904965106. Epub 2009 Nov 16.


4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway.

Chaudhary P, Sharma R, Sahu M, Vishwanatha JK, Awasthi S, Awasthi YC.

J Biol Chem. 2013 Jul 12;288(28):20532-46. doi: 10.1074/jbc.M113.467662. Epub 2013 Jun 3.


Ataxia-telangiectasia mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues.

Gurley KE, Kemp CJ.

Mol Cancer Res. 2007 Dec;5(12):1312-8. doi: 10.1158/1541-7786.MCR-07-0223.


Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice.

Lu YP, Lou YR, Peng QY, Xie JG, Nghiem P, Conney AH.

Cancer Res. 2008 Apr 1;68(7):2523-9. doi: 10.1158/0008-5472.CAN-07-5955.


ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.

Fang Y, Tsao CC, Goodman BK, Furumai R, Tirado CA, Abraham RT, Wang XF.

EMBO J. 2004 Aug 4;23(15):3164-74. Epub 2004 Jul 29.


Mouse models for ATR deficiency.

O'Driscoll M.

DNA Repair (Amst). 2009 Nov 2;8(11):1333-7. doi: 10.1016/j.dnarep.2009.09.001. Epub 2009 Sep 25. Review.


Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita.

He H, Wang Y, Guo X, Ramchandani S, Ma J, Shen MF, Garcia DA, Deng Y, Multani AS, You MJ, Chang S.

Mol Cell Biol. 2009 Jan;29(1):229-40. doi: 10.1128/MCB.01400-08. Epub 2008 Oct 20.


Differential function of NBS1 and ATR in neurogenesis.

Zhou Z, Bruhn C, Wang ZQ.

DNA Repair (Amst). 2012 Feb 1;11(2):210-21. doi: 10.1016/j.dnarep.2011.10.021. Epub 2011 Nov 9.

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