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Items: 1 to 20 of 103


Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.

Lindqvist A, de Bruijn M, Macurek L, Brás A, Mensinga A, Bruinsma W, Voets O, Kranenburg O, Medema RH.

EMBO J. 2009 Oct 21;28(20):3196-206. doi: 10.1038/emboj.2009.246. Epub 2009 Aug 27.


Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.

Liu XS, Li H, Song B, Liu X.

EMBO Rep. 2010 Aug;11(8):626-32. doi: 10.1038/embor.2010.90. Epub 2010 Jun 25.


Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling.

Jurvansuu J, Fragkos M, Ingemarsdotter C, Beard P.

J Mol Biol. 2007 Sep 14;372(2):397-406. Epub 2007 Jul 3.


Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.

Yoda A, Toyoshima K, Watanabe Y, Onishi N, Hazaka Y, Tsukuda Y, Tsukada J, Kondo T, Tanaka Y, Minami Y.

J Biol Chem. 2008 Jul 4;283(27):18969-79. doi: 10.1074/jbc.M800560200. Epub 2008 May 15.


The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.

Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA.

Cancer Cell. 2007 Oct;12(4):342-54.


Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation.

Minemoto Y, Uchida S, Ohtsubo M, Shimura M, Sasagawa T, Hirata M, Nakagama H, Ishizaka Y, Yamashita K.

Arch Biochem Biophys. 2003 Apr 1;412(1):13-9.


Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A.

Jang YJ, Ji JH, Choi YC, Ryu CJ, Ko SY.

J Biol Chem. 2007 Jan 26;282(4):2473-82. Epub 2006 Nov 22.


NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest.

Manni I, Mazzaro G, Gurtner A, Mantovani R, Haugwitz U, Krause K, Engeland K, Sacchi A, Soddu S, Piaggio G.

J Biol Chem. 2001 Feb 23;276(8):5570-6. Epub 2000 Nov 28.


Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.

Kleiblova P, Shaltiel IA, Benada J, Ševčík J, Pecháčková S, Pohlreich P, Voest EE, Dundr P, Bartek J, Kleibl Z, Medema RH, Macurek L.

J Cell Biol. 2013 May 13;201(4):511-21. doi: 10.1083/jcb.201210031. Epub 2013 May 6.


PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.

Lu X, Nannenga B, Donehower LA.

Genes Dev. 2005 May 15;19(10):1162-74. Epub 2005 May 3.


p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors.

Park JY, Song JY, Kim HM, Han HS, Seol HS, Jang SJ, Choi J.

Int J Biochem Cell Biol. 2012 Jun;44(6):896-904. doi: 10.1016/j.biocel.2012.02.013. Epub 2012 Feb 24.


Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation.

Ismail IA, Kang KS, Lee HA, Kim JW, Sohn YK.

Eur J Pharmacol. 2007 Dec 1;575(1-3):12-20. Epub 2007 Jul 28.


Distinct phosphatases antagonize the p53 response in different phases of the cell cycle.

Shaltiel IA, Aprelia M, Saurin AT, Chowdhury D, Kops GJ, Voest EE, Medema RH.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7313-8. doi: 10.1073/pnas.1322021111. Epub 2014 Apr 7.


Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.

Lu X, Nguyen TA, Donehower LA.

Cell Cycle. 2005 Aug;4(8):1060-4. Epub 2005 Aug 26.


Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy.

Studach L, Wang WH, Weber G, Tang J, Hullinger RL, Malbrue R, Liu X, Andrisani O.

J Biol Chem. 2010 Sep 24;285(39):30282-93. doi: 10.1074/jbc.M109.093963. Epub 2010 Jul 12.


Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells.

van Vugt MA, Brás A, Medema RH.

Mol Cell. 2004 Sep 10;15(5):799-811.


The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells.

Engelbert D, Schnerch D, Baumgarten A, Wäsch R.

Oncogene. 2008 Feb 7;27(7):907-17. Epub 2007 Aug 13.


Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.

Fujimoto H, Onishi N, Kato N, Takekawa M, Xu XZ, Kosugi A, Kondo T, Imamura M, Oishi I, Yoda A, Minami Y.

Cell Death Differ. 2006 Jul;13(7):1170-80. Epub 2005 Nov 25.


Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L, Stern DF.

Cell Cycle. 2005 Jan;4(1):166-71. Epub 2005 Jan 5.

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