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Items: 1 to 20 of 126


Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation.

Dela Cruz CS, Viswanathan SR, El-Guindy AS, Shedd D, Miller G.

J Biol Chem. 2009 Oct 23;284(43):29269-82. doi: 10.1074/jbc.M109.039115. Epub 2009 Aug 18.


Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus.

Aoki Y, Narazaki M, Kishimoto T, Tosato G.

Blood. 2001 Nov 15;98(10):3042-9.


Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.

Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J.

J Virol. 2009 May;83(10):5117-26. doi: 10.1128/JVI.01601-08. Epub 2009 Mar 4.


Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6.

Boulanger MJ, Chow DC, Brevnova E, Martick M, Sandford G, Nicholas J, Garcia KC.

J Mol Biol. 2004 Jan 9;335(2):641-54.


Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells.

Hoischen SH, Vollmer P, März P, Ozbek S, Götze KS, Peschel C, Jostock T, Geib T, Müllberg J, Mechtersheimer S, Fischer M, Grötzinger J, Galle PR, Rose-John S.

Eur J Biochem. 2000 Jun;267(12):3604-12.


IL-6 receptor independent stimulation of human gp130 by viral IL-6.

Müllberg J, Geib T, Jostock T, Hoischen SH, Vollmer P, Voltz N, Heinz D, Galle PR, Klouche M, Rose-John S.

J Immunol. 2000 May 1;164(9):4672-7.


Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.

Veverka V, Baker T, Redpath NT, Carrington B, Muskett FW, Taylor RJ, Lawson AD, Henry AJ, Carr MD.

J Biol Chem. 2012 Nov 16;287(47):40043-50. doi: 10.1074/jbc.M112.405597. Epub 2012 Oct 1.


N-linked glycosylation is required for optimal function of Kaposi's sarcoma herpesvirus-encoded, but not cellular, interleukin 6.

Dela Cruz CS, Lee Y, Viswanathan SR, El-Guindy AS, Gerlach J, Nikiforow S, Shedd D, Gradoville L, Miller G.

J Exp Med. 2004 Feb 16;199(4):503-14.


Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.

Sudarman E, Bollati-Fogolín M, Hafner M, Müller W, Scheller J, Rose-John S, Eichler J.

Chem Biol Drug Des. 2008 May;71(5):494-500. doi: 10.1111/j.1747-0285.2008.00649.x. Epub 2008 Mar 25.


Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization.

Suthaus J, Adam N, Grötzinger J, Scheller J, Rose-John S.

Eur J Cell Biol. 2011 Jun-Jul;90(6-7):495-504. doi: 10.1016/j.ejcb.2010.10.016. Epub 2010 Dec 21. Review.


Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6.

Chen D, Choi YB, Sandford G, Nicholas J.

J Virol. 2009 Jul;83(13):6874-82. doi: 10.1128/JVI.02625-08. Epub 2009 Apr 22.


Role of human herpesvirus 8 interleukin-6-activated gp130 signal transducer in primary effusion lymphoma cell growth and viability.

Cousins E, Nicholas J.

J Virol. 2013 Oct;87(19):10816-27. doi: 10.1128/JVI.02047-13. Epub 2013 Jul 31.


Human herpesvirus 8-encoded interleukin-6 homologue (viral IL-6) induces endogenous human IL-6 secretion.

Mori Y, Nishimoto N, Ohno M, Inagi R, Dhepakson P, Amou K, Yoshizaki K, Yamanishi K.

J Med Virol. 2000 Jul;61(3):332-5.

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