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Plasma amyloid-beta peptide levels correlate with adipocyte amyloid precursor protein gene expression in obese individuals.

Lee YH, Martin JM, Maple RL, Tharp WG, Pratley RE.

Neuroendocrinology. 2009;90(4):383-90. doi: 10.1159/000235555. Epub 2009 Aug 12.


Amyloid precursor protein expression is upregulated in adipocytes in obesity.

Lee YH, Tharp WG, Maple RL, Nair S, Permana PA, Pratley RE.

Obesity (Silver Spring). 2008 Jul;16(7):1493-500. doi: 10.1038/oby.2008.267. Epub 2008 May 15.


Increased amyloid beta protein levels in children and adolescents with Down syndrome.

Mehta PD, Capone G, Jewell A, Freedland RL.

J Neurol Sci. 2007 Mar 15;254(1-2):22-7. Epub 2007 Feb 2.


Expression of APP pathway mRNAs and proteins in Alzheimer's disease.

Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT.

Brain Res. 2007 Aug 3;1161:116-23. Epub 2007 Jun 5.


Plasma PTX3 protein levels inversely correlate with insulin secretion and obesity, whereas visceral adipose tissue PTX3 gene expression is increased in obesity.

Osorio-Conles O, Guitart M, Chacón MR, Maymo-Masip E, Moreno-Navarrete JM, Montori-Grau M, Näf S, Fernandez-Real JM, Vendrell J, Gómez-Foix AM.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1254-61. doi: 10.1152/ajpendo.00163.2011. Epub 2011 Sep 6.


Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome.

Abrahamson EE, Ikonomovic MD, Ciallella JR, Hope CE, Paljug WR, Isanski BA, Flood DG, Clark RS, DeKosky ST.

Exp Neurol. 2006 Feb;197(2):437-50. Epub 2005 Nov 21.


Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss.

Bruun JM, Stallknecht B, Helge JW, Richelsen B.

Eur J Endocrinol. 2007 Oct;157(4):465-71.


LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.

Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, Ma L, Shughrue P, Burchard J, Colussi D, Pietrak B, Kahana J, Beher D, Rosahl T, Shearman M, Hazuda D, Sachs AB, Koblan KS, Seabrook GR, Stone DJ.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17967-72. Epub 2006 Nov 10.


Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications.

Yang RZ, Lee MJ, Hu H, Pollin TI, Ryan AS, Nicklas BJ, Snitker S, Horenstein RB, Hull K, Goldberg NH, Goldberg AP, Shuldiner AR, Fried SK, Gong DW.

PLoS Med. 2006 Jun;3(6):e287.


Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.


Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Abeta42 reduces their differentiation potential.

Uhrig M, Brechlin P, Jahn O, Knyazev Y, Weninger A, Busia L, Honarnejad K, Otto M, Hartmann T.

BMC Med. 2008 Dec 16;6:38. doi: 10.1186/1741-7015-6-38.


P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.

J Pharmacol Exp Ther. 2008 Aug;326(2):502-13. doi: 10.1124/jpet.108.138974. Epub 2008 May 22.


Regulation of Alzheimer beta-amyloid precursor trafficking and metabolism.

Gandy S, Petanceska S.

Biochim Biophys Acta. 2000 Jul 26;1502(1):44-52. Review.


GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.


11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle.

Nair S, Lee YH, Lindsay RS, Walker BR, Tataranni PA, Bogardus C, Baier LJ, Permana PA.

Diabetologia. 2004 Jun;47(6):1088-95. Epub 2004 May 20.


Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.

Wang PL, Niidome T, Akaike A, Kihara T, Sugimoto H.

J Neurosci Res. 2009 Jul;87(9):2105-14. doi: 10.1002/jnr.22039.

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