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19665469,17356170,15456916,18367319,15714390,8504742,19130882,16464945,15857972,16965620,16138832,9607801,19584281,9202215,16145313,17118173,11783365,8944075,17303655,16613890,16778450,20414849,15870863,8921337,17761890,17118172,24739643,8425470,9630742,18638473,11133684,16202921,15713363,28300476,16449295,15790602,22796107,15806153,15831511,16616843,18508261,20869048,15613455,19176543,16210018,27776183,18304981,22027501,12009357,15972881,8504763,16274925,23183084,15509668,24373455,14667995,16352672,15240642,26945725,9459197,23454116,26725037,10465261,29615065,33823166,11035983,15564322,16020483,23553368,36187129,11682628,23650939,18583549,27641443,26631549,11546554,3996316,12943742,23727370,16418212,32412587,17659312,12456805,11566438,15864926,25406186,3275538,25461906,16510375,28161388,19072476,18765509,9603252,12130573,9205050,11294976,16406281,20073985,25882702,10774816,4039656,9780321,2004041,18097065,18988805,10774817,26080942,10840165,10027611,24740602,8688809,12385821,30078406,23183181,8499337,24586072,8943541,22271293,3394473,8031708,32365199,24824367,10684792,23710982,12960051,29383962,8030698,27556454,7631670,17893877,11482902,17056225,21586552,27371899,22272226,23178161,26879975,18540573,20043998,10342861,11949964,20104427,10845803,8163495,16800253,23303565,24787486,3626549,17023524,2737155,33411206,21641908,19372202,9794483,27503693,20419096,32152908,26200398,27980309,30809650,27632388,8862768,18632874,26614455,10727250,16223974,25174783,11910661,3345728,26165333,33914997,8612533,26487511,23025258,23972920,22534326,26908459,2457133,25353185,9459190,1562505,26036805,20124487,26243545,14602803,25171950,18824103,21719062,26447143,8664174,18606537,31754172,23913972,23874806,20354353,8960899,20203127,22959316,26447688,10823946,25218441,24708211,2351113,7587192,22149760,19389829,3365472,22252173,24239717,36863794,10460226,24316382,11419961,28412809,25201168,21693674,23171676,18363513,15125925,32781695,2069862,18830694,29928930,35784569,23739217,33966185,9743896,18177995,26157037,3297211,26335175,1991538,1727726,22155565,15814773,11108892,8710941,21480232,2772964,25844270,28078471,28637327,29223656,29736565,11360638,14519088,11108882,17630709,10893236,573050,29338440,8462459,16920353,12052661,10374120,32468067,28482330,21600232,24484171,11108894,21906450,20375184,23607964,22114766,29485640,10599550,18559275,25100707,25609169,22484153,11108885,9687320,7342722,3207802,36419064,17824176,16126628,25337190,2095592,163981,20660062,26800447,16690946,21228508,22964137,27287056,9738695,12661281,28925396,16597452,17640991,14500559,20720261,10208978,19000019,32004675,3609907,10976068,16574737,36000243,27018534,10027612,23111860,18991020,25791399,30393115,18923157,20493256,17202821,20104426,26204463,24418098,26645363,3702406,2262937,23774084,2466705,22245609,21628418,22163294,27007157,6568878,12227898,21695351,27817837,19848300,23579486,8073007,24140060,22638070,18719766,30044157,30018014,25635622,34935393,29730442,30010222,3411580,26588841,1438251,31904879,15109649,36068753,14668001,30091552,20108182,1995287,19372222,7711211,22535964,6824739,24664419,25587053,27315780,30013514,36308434,28586424,34034233,36252793,24296832,20452152,26639431,14667992,29199806,9384255,30357380,12454529,23566615,22353808,14709872,3581149,36863793,11011074,30623764,24992181,26544941,11397560,24489989,11105987,30407750,20720260,21693775,18754282,30745115,18008187,9453243,12052437,3682817,32739288,18666641,18778185,16955145,30957588,9431442,8831902,31812531,29353143,26228249,22033264,30743741,3712034,34405378,20456973,7557380,7961858,17056036,37108154,24500783,18778184,28569249,23113924,7626499,22238285,28827707,4356767,1550389,36529967,1991537,11215689,16101406,16548789,19497994,21150157,20042678,13868870,12238914,24982875,18543433,20370704,7662586,26905830,28828592,29559388,29738691,22700766,31732361,171505,25134298,25337560,17431228,34524172,19926282,33899118,32599565,9697076,19076002,12781197,30205508,21463255,11056336,4829347,18246050,8424892,17118166,7390003,35342349,36139138,26777300,8318587,5244364,32700282,5108492,2921869,8355486,31499479,27121188,11859003,13408318,33987175,6372097,28407578,35441077,25242338,26163756,26350007,29434492,35203298,36845134,8735587,15119192,25143815,35457166,27091197,31134186,19442080,29237804,30803797,32529777,35776850,35782354,36752314,29972430,22363725,26939826,18616415,26994067,35689838,12711023,23398087,8594304,25664066,18778186,4761875,27001066,35084123,20406552,23227010,25609165,36986136,5918612,25530789,18406695,7579907,27994732,4760428,34827682,32774432,13718997,33850448,31508191,34194730,28261281,13498068,9736925,18880533,25961222,14940551,26622367,29787667,18537687,30008440,9010340,13901141,24900294,5114074,11209734,11108896,17872740,29272819,10837599,13309342,14393453,31643562,26538810,12982411,25678821,23795205,33386111,32678337,14395249,23394658,30132301,32542406,30754131,28200396,26571363,21433936[uid]

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Estrogen-induced stromal cell-derived factor-1 (SDF-1/Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor alpha in rat uterine cells and tissues.

Glace L, Grygielko ET, Boyle R, Wang Q, Laping NJ, Sulpizio AC, Bray JD. Glace L, et al. Steroids. 2009 Nov-Dec;74(13-14):1015-24. doi: 10.1016/j.steroids.2009.07.011. Epub 2009 Aug 7. Steroids. 2009. PMID: 19665469

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.

Madauss KP, Grygielko ET, Deng SJ, Sulpizio AC, Stanley TB, Wu C, Short SA, Thompson SK, Stewart EL, Laping NJ, Williams SP, Bray JD. Madauss KP, et al. Mol Endocrinol. 2007 May;21(5):1066-81. doi: 10.1210/me.2006-0524. Epub 2007 Mar 13. Mol Endocrinol. 2007. PMID: 17356170

Effect of genistein as a selective estrogen receptor beta agonist on the expression of Calbindin-D9k in the uterus of immature rats.

Lee GS, Choi KC, Kim HJ, Jeung EB. Lee GS, et al. Toxicol Sci. 2004 Dec;82(2):451-7. doi: 10.1093/toxsci/kfh296. Epub 2004 Sep 29. Toxicol Sci. 2004. PMID: 15456916

Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland.

Crabtree JS, Peano BJ, Zhang X, Komm BS, Winneker RC, Harris HA. Crabtree JS, et al. Mol Cell Endocrinol. 2008 Jun 11;287(1-2):40-6. doi: 10.1016/j.mce.2008.01.027. Epub 2008 Feb 12. Mol Cell Endocrinol. 2008. PMID: 18367319

Discovery, chemistry, and reproductive pharmacology of asoprisnil and related 11beta-benzaldoxime substituted selective progesterone receptor modulators (SPRMs).

Schubert G, Elger W, Kaufmann G, Schneider B, Reddersen G, Chwalisz K. Schubert G, et al. Semin Reprod Med. 2005 Feb;23(1):58-73. doi: 10.1055/s-2005-864034. Semin Reprod Med. 2005. PMID: 15714390 Review.

Regulation of progesterone receptor gene expression and growth in the rat uterus: modulation of estrogen actions by progesterone and sex steroid hormone antagonists.

Kraus WL, Katzenellenbogen BS. Kraus WL, et al. Endocrinology. 1993 Jun;132(6):2371-9. doi: 10.1210/endo.132.6.8504742. Endocrinology. 1993. PMID: 8504742

Global gene expression profiling of progesterone receptor modulators in T47D cells provides a new classification system.

Afhüppe W, Sommer A, Müller J, Schwede W, Fuhrmann U, Möller C. Afhüppe W, et al. J Steroid Biochem Mol Biol. 2009 Jan;113(1-2):105-15. doi: 10.1016/j.jsbmb.2008.11.015. Epub 2008 Dec 14. J Steroid Biochem Mol Biol. 2009. PMID: 19130882

A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.

Chen W, Ohara N, Wang J, Xu Q, Liu J, Morikawa A, Sasaki H, Yoshida S, Demanno DA, Chwalisz K, Maruo T. Chen W, et al. J Clin Endocrinol Metab. 2006 Apr;91(4):1296-304. doi: 10.1210/jc.2005-2379. Epub 2006 Feb 7. J Clin Endocrinol Metab. 2006. PMID: 16464945

Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis.

Chwalisz K, Perez MC, Demanno D, Winkel C, Schubert G, Elger W. Chwalisz K, et al. Endocr Rev. 2005 May;26(3):423-38. doi: 10.1210/er.2005-0001. Epub 2005 Apr 27. Endocr Rev. 2005. PMID: 15857972 Review.

Tissue- and hormone-dependent progesterone receptor distribution in the rat uterus.

Sahlin L, Masironi B, Akerberg S, Eriksson H. Sahlin L, et al. Reprod Biol Endocrinol. 2006 Sep 11;4:47. doi: 10.1186/1477-7827-4-47. Reprod Biol Endocrinol. 2006. PMID: 16965620 Free PMC article.

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