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Items: 1 to 20 of 96


A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.

Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA.

Mol Cell. 2009 Jul 31;35(2):228-39. doi: 10.1016/j.molcel.2009.06.021.


A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.

O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW.

Mol Cell. 2010 Nov 24;40(4):645-57. doi: 10.1016/j.molcel.2010.10.022. Epub 2010 Nov 4.


DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.

An J, Huang YC, Xu QZ, Zhou LJ, Shang ZF, Huang B, Wang Y, Liu XD, Wu DC, Zhou PK.

BMC Mol Biol. 2010 Mar 6;11:18. doi: 10.1186/1471-2199-11-18.


PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase.

Tardat M, Murr R, Herceg Z, Sardet C, Julien E.

J Cell Biol. 2007 Dec 31;179(7):1413-26. Epub 2007 Dec 24.


Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.

Arango D, Parihar A, Villamena FA, Wang L, Freitas MA, Grotewold E, Doseff AI.

Biochem Pharmacol. 2012 Dec 15;84(12):1571-80. doi: 10.1016/j.bcp.2012.09.005. Epub 2012 Sep 14.


ATR and H2AX cooperate in maintaining genome stability under replication stress.

Chanoux RA, Yin B, Urtishak KA, Asare A, Bassing CH, Brown EJ.

J Biol Chem. 2009 Feb 27;284(9):5994-6003. doi: 10.1074/jbc.M806739200. Epub 2008 Dec 2.


Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X, Lei B, Zhou N, Feng B, Yao W, Zhao X, Yu Y, Lu H.

BMC Genomics. 2012 Nov 23;13:662. doi: 10.1186/1471-2164-13-662.


DNA damage response.

Giglia-Mari G, Zotter A, Vermeulen W.

Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a000745. doi: 10.1101/cshperspect.a000745. Review.


Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis.

Halicka HD, Huang X, Traganos F, King MA, Dai W, Darzynkiewicz Z.

Cell Cycle. 2005 Feb;4(2):339-45. Epub 2005 Feb 21.


DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication.

Müller B, Blackburn J, Feijoo C, Zhao X, Smythe C.

J Cell Biol. 2007 Dec 31;179(7):1385-98. Epub 2007 Dec 24. Erratum in: J Cell Biol. 2008 Feb 25;180(4):843.


Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability.

Savage KI, Gorski JJ, Barros EM, Irwin GW, Manti L, Powell AJ, Pellagatti A, Lukashchuk N, McCance DJ, McCluggage WG, Schettino G, Salto-Tellez M, Boultwood J, Richard DJ, McDade SS, Harkin DP.

Mol Cell. 2014 May 8;54(3):445-59. doi: 10.1016/j.molcel.2014.03.021. Epub 2014 Apr 17.


Histone demethylase KDM5B is a key regulator of genome stability.

Li X, Liu L, Yang S, Song N, Zhou X, Gao J, Yu N, Shan L, Wang Q, Liang J, Xuan C, Wang Y, Shang Y, Shi L.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7096-101. doi: 10.1073/pnas.1324036111. Epub 2014 Apr 28.


Triplex-induced DNA damage response.

Rogers FA, Tiwari MK.

Yale J Biol Med. 2013 Dec 13;86(4):471-8.


The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins.

Krishnan N, Titus MA, Thapar R.

PLoS One. 2014 Jan 9;9(1):e85427. doi: 10.1371/journal.pone.0085427. eCollection 2014.


MDC1 is a mediator of the mammalian DNA damage checkpoint.

Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.

Nature. 2003 Feb 27;421(6926):961-6.


gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

Cowell IG, Sunter NJ, Singh PB, Austin CA, Durkacz BW, Tilby MJ.

PLoS One. 2007 Oct 24;2(10):e1057.


Replication independent DNA double-strand break retention may prevent genomic instability.

Kongruttanachok N, Phuangphairoj C, Thongnak A, Ponyeam W, Rattanatanyong P, Pornthanakasem W, Mutirangura A.

Mol Cancer. 2010 Mar 31;9:70. doi: 10.1186/1476-4598-9-70.


Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage.

Jha S, Shibata E, Dutta A.

Mol Cell Biol. 2008 Apr;28(8):2690-700. doi: 10.1128/MCB.01983-07. Epub 2008 Feb 19.


Genetic epidemiology of Charcot-Marie-Tooth disease.

Braathen GJ.

Acta Neurol Scand Suppl. 2012;(193):iv-22. doi: 10.1111/ane.12013.

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