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Results: 1 to 20 of 103

1.

Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia.

Linger RM, DeRyckere D, Brandão L, Sawczyn KK, Jacobsen KM, Liang X, Keating AK, Graham DK.

Blood. 2009 Sep 24;114(13):2678-87. doi: 10.1182/blood-2009-03-209247. Epub 2009 Jul 30. Retraction in: Blood. 2012 Aug 16;120(7):1533.

PMID:
19643988
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia.

Linger RM, Lee-Sherick AB, DeRyckere D, Cohen RA, Jacobsen KM, McGranahan A, Brandão LN, Winges A, Sawczyn KK, Liang X, Keating AK, Tan AC, Earp HS, Graham DK.

Blood. 2013 Aug 29;122(9):1599-609. doi: 10.1182/blood-2013-01-478156. Epub 2013 Jul 16.

PMID:
23861246
[PubMed - indexed for MEDLINE]
3.

Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis.

Sarvaiya PJ, Schwartz JR, Hernandez CP, Rodriguez PC, Vedeckis WV.

Am J Hematol. 2012 Oct;87(10):969-76. doi: 10.1002/ajh.23283. Epub 2012 Jul 5.

PMID:
22764095
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo.

Christoph S, Deryckere D, Schlegel J, Frazer JK, Batchelor LA, Trakhimets AY, Sather S, Hunter DM, Cummings CT, Liu J, Yang C, Kireev D, Simpson C, Norris-Drouin J, Hull-Ryde EA, Janzen WP, Johnson GL, Wang X, Frye SV, Earp HS 3rd, Graham DK.

Mol Cancer Ther. 2013 Nov;12(11):2367-77. doi: 10.1158/1535-7163.MCT-13-0040. Epub 2013 Aug 30.

PMID:
23997116
[PubMed - indexed for MEDLINE]
5.

GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche.

Shiozawa Y, Pedersen EA, Taichman RS.

Exp Hematol. 2010 Feb;38(2):132-40. doi: 10.1016/j.exphem.2009.11.002. Epub 2009 Nov 14.

PMID:
19922767
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia.

Lee-Sherick AB, Eisenman KM, Sather S, McGranahan A, Armistead PM, McGary CS, Hunsucker SA, Schlegel J, Martinson H, Cannon C, Keating AK, Earp HS, Liang X, DeRyckere D, Graham DK.

Oncogene. 2013 Nov 14;32(46):5359-68. doi: 10.1038/onc.2013.40. Epub 2013 Mar 11.

PMID:
23474756
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo.

O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A, Smolich BD, Manning WC, Murray LJ, Heinrich MC, Cherrington JM.

Blood. 2003 May 1;101(9):3597-605. Epub 2003 Jan 16.

PMID:
12531805
[PubMed - indexed for MEDLINE]
Free Article
8.

The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia.

Saunders P, Cisterne A, Weiss J, Bradstock KF, Bendall LJ.

Haematologica. 2011 Jan;96(1):69-77. doi: 10.3324/haematol.2010.026997. Epub 2010 Oct 15.

PMID:
20952516
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity.

Keating AK, Kim GK, Jones AE, Donson AM, Ware K, Mulcahy JM, Salzberg DB, Foreman NK, Liang X, Thorburn A, Graham DK.

Mol Cancer Ther. 2010 May;9(5):1298-307. doi: 10.1158/1535-7163.MCT-09-0707. Epub 2010 Apr 27.

PMID:
20423999
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy.

Sengupta TK, Leclerc GM, Hsieh-Kinser TT, Leclerc GJ, Singh I, Barredo JC.

Mol Cancer. 2007 Jul 10;6:46.

PMID:
17623090
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia.

Meng X, Matlawska-Wasowska K, Girodon F, Mazel T, Willman CL, Atlas S, Chen IM, Harvey RC, Hunger SP, Ness SA, Winter SS, Wilson BS.

Leukemia. 2011 Jul;25(7):1135-46. doi: 10.1038/leu.2011.50. Epub 2011 Apr 15.

PMID:
21494254
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Small-molecule inhibitors of Bcl-2 family proteins are able to induce tumor regression in a mouse model of pre-B-cell acute lymphocytic lymphoma.

Turner BC, Eves T, Refaeli Y.

DNA Cell Biol. 2008 Mar;27(3):133-42. doi: 10.1089/dna.2007.0675.

PMID:
18163880
[PubMed - indexed for MEDLINE]
13.

Acute lymphoblastic leukemia cells treated with CpG oligodeoxynucleotides, IL-4 and CD40 ligand facilitate enhanced anti-leukemic CTL responses.

Fabricius D, Breckerbohm L, Vollmer A, Queudeville M, Eckhoff SM, Fulda S, Strauss G, Debatin KM, Jahrsdörfer B, Meyer LH.

Leukemia. 2011 Jul;25(7):1111-21. doi: 10.1038/leu.2011.87. Epub 2011 Apr 29.

PMID:
21527935
[PubMed - indexed for MEDLINE]
14.

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.

Maude SL, Tasian SK, Vincent T, Hall JW, Sheen C, Roberts KG, Seif AE, Barrett DM, Chen IM, Collins JR, Mullighan CG, Hunger SP, Harvey RC, Willman CL, Fridman JS, Loh ML, Grupp SA, Teachey DT.

Blood. 2012 Oct 25;120(17):3510-8. doi: 10.1182/blood-2012-03-415448. Epub 2012 Sep 6.

PMID:
22955920
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin.

Parameswaran R, Yu M, Lyu MA, Lim M, Rosenblum MG, Groffen J, Heisterkamp N.

Leukemia. 2012 Aug;26(8):1786-96. doi: 10.1038/leu.2012.54. Epub 2012 Feb 29.

PMID:
22373785
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Evaluation of the NOD/SCID xenograft model for glucocorticoid-regulated gene expression in childhood B-cell precursor acute lymphoblastic leukemia.

Bhadri VA, Cowley MJ, Kaplan W, Trahair TN, Lock RB.

BMC Genomics. 2011 Nov 17;12:565. doi: 10.1186/1471-2164-12-565.

PMID:
22093874
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma.

Shi JQ, Lasky K, Shinde V, Stringer B, Qian MG, Liao D, Liu R, Driscoll D, Nestor MT, Amidon BS, Rao Y, Duffey MO, Manfredi MG, Vos TJ, D' Amore N, Hyer ML.

Mol Cancer Ther. 2012 Sep;11(9):2045-53. doi: 10.1158/1535-7163.MCT-11-1036. Epub 2012 May 18.

PMID:
22609854
[PubMed - indexed for MEDLINE]
Free Article
18.

Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase.

Keating AK, Salzberg DB, Sather S, Liang X, Nickoloff S, Anwar A, Deryckere D, Hill K, Joung D, Sawczyn KK, Park J, Curran-Everett D, McGavran L, Meltesen L, Gore L, Johnson GL, Graham DK.

Oncogene. 2006 Oct 5;25(45):6092-100. Epub 2006 May 1.

PMID:
16652142
[PubMed - indexed for MEDLINE]
19.

Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia.

Wallington-Beddoe CT, Don AS, Hewson J, Qiao Q, Papa RA, Lock RB, Bradstock KF, Bendall LJ.

PLoS One. 2012;7(5):e36429. doi: 10.1371/journal.pone.0036429. Epub 2012 May 3. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/d7342840-682b-4ee2-bb41-7b41aa5dedf7.

PMID:
22570713
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies.

Dave H, Anver MR, Butcher DO, Brown P, Khan J, Wayne AS, Baskar S, Rader C.

PLoS One. 2012;7(12):e52655. doi: 10.1371/journal.pone.0052655. Epub 2012 Dec 20.

PMID:
23285131
[PubMed - indexed for MEDLINE]
Free PMC Article

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