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Items: 1 to 20 of 159

1.

Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.

Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X.

Am J Pathol. 2009 Aug;175(2):772-85. doi: 10.2353/ajpath.2009.081099. Epub 2009 Jul 23.

2.

Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ.

J Bone Miner Res. 2009 Feb;24(2):251-64. doi: 10.1359/jbmr.081002.

3.

Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice.

Li M, Healy DR, Li Y, Simmons HA, Crawford DT, Ke HZ, Pan LC, Brown TA, Thompson DD.

Bone. 2005 Jul;37(1):46-54.

PMID:
15869929
4.

EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair.

Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ.

J Bone Miner Res. 2011 Apr;26(4):792-802. doi: 10.1002/jbmr.272.

5.

Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors.

Hatazawa R, Tanaka A, Tanigami M, Amagase K, Kato S, Ashida Y, Takeuchi K.

Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G788-97. Epub 2007 Aug 2.

6.

COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.

Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M.

Am J Pathol. 2010 Mar;176(3):1469-83. doi: 10.2353/ajpath.2010.090607. Epub 2010 Jan 28.

7.
9.

Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3, and EP4 prostanoid receptor activation.

Iwanaga K, Okada M, Murata T, Hori M, Ozaki H.

J Pharmacol Exp Ther. 2012 Mar;340(3):604-11. doi: 10.1124/jpet.111.189845. Epub 2011 Dec 2.

10.

Non-steroidal anti-inflammatory drugs, cyclooxygenase-2 and the bone healing process.

Vuolteenaho K, Moilanen T, Moilanen E.

Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):10-4. Epub 2007 Oct 31. Review.

11.

EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures.

Minamizaki T, Yoshiko Y, Kozai K, Aubin JE, Maeda N.

Bone. 2009 Jun;44(6):1177-85. doi: 10.1016/j.bone.2009.02.010. Epub 2009 Feb 21.

PMID:
19233324
12.

Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors.

Takeuchi K, Tanigami M, Amagase K, Ochi A, Okuda S, Hatazawa R.

J Gastroenterol Hepatol. 2010 May;25 Suppl 1:S67-74. doi: 10.1111/j.1440-1746.2010.06222.x.

PMID:
20586869
13.

Prostaglandin E(2) receptors in bone formation.

Li M, Thompson DD, Paralkar VM.

Int Orthop. 2007 Dec;31(6):767-72. Epub 2007 Jun 26. Review.

14.

Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence.

Graham S, Gamie Z, Polyzois I, Narvani AA, Tzafetta K, Tsiridis E, Helioti M, Mantalaris A, Tsiridis E.

Expert Opin Investig Drugs. 2009 Jun;18(6):746-66. doi: 10.1517/13543780902893051 . Review.

PMID:
19426119
15.

CD40 engagement on dendritic cells induces cyclooxygenase-2 and EP2 receptor via p38 and ERK MAPKs.

Harizi H, Limem I, Gualde N.

Immunol Cell Biol. 2011 Feb;89(2):275-82. doi: 10.1038/icb.2010.94. Epub 2010 Aug 10.

PMID:
20697426
16.

An EP2 receptor-selective prostaglandin E2 agonist induces bone healing.

Paralkar VM, Borovecki F, Ke HZ, Cameron KO, Lefker B, Grasser WA, Owen TA, Li M, DaSilva-Jardine P, Zhou M, Dunn RL, Dumont F, Korsmeyer R, Krasney P, Brown TA, Plowchalk D, Vukicevic S, Thompson DD.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6736-40. Epub 2003 May 14.

17.

Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages.

Pavlovic S, Du B, Sakamoto K, Khan KM, Natarajan C, Breyer RM, Dannenberg AJ, Falcone DJ.

J Biol Chem. 2006 Feb 10;281(6):3321-8. Epub 2005 Dec 7.

19.

Role of prostaglandin E receptor subtypes EP2 and EP4 in autocrine and paracrine functions of vascular endothelial growth factor in the inner ear.

Hori R, Nakagawa T, Yamamoto N, Hamaguchi K, Ito J.

BMC Neurosci. 2010 Mar 11;11:35. doi: 10.1186/1471-2202-11-35.

20.
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