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Results: 1 to 20 of 81

1.

An in silico study of the molecular basis of B-RAF activation and conformational stability.

Fratev FF, Jónsdóttir SO.

BMC Struct Biol. 2009 Jul 22;9:47. doi: 10.1186/1472-6807-9-47.

PMID:
19624854
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Molecular basis of inactive B-RAF(WT) and B-RAF(V600E) ligand inhibition, selectivity and conformational stability: an in silico study.

Fratev F, Jónsdóttir SO, Mihaylova E, Pajeva I.

Mol Pharm. 2009 Jan-Feb;6(1):144-57. doi: 10.1021/mp8001107.

PMID:
19248232
[PubMed - indexed for MEDLINE]
3.

The phosphorylation specificity of B-RAF WT, B-RAF D594V, B-RAF V600E and B-RAF K601E kinases: an in silico study.

Fratev F, Jónsdóttir SO.

J Mol Graph Model. 2010 Apr;28(7):598-603. doi: 10.1016/j.jmgm.2009.12.005. Epub 2009 Dec 24.

PMID:
20093060
[PubMed - indexed for MEDLINE]
4.

Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: the role of N-region in the evolutionary divergence of RAF kinase function in vertebrates.

Baljuls A, Mueller T, Drexler HC, Hekman M, Rapp UR.

J Biol Chem. 2007 Sep 7;282(36):26575-90. Epub 2007 Jul 5.

PMID:
17613527
[PubMed - indexed for MEDLINE]
Free Article
5.

Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein.

Brummer T, Martin P, Herzog S, Misawa Y, Daly RJ, Reth M.

Oncogene. 2006 Oct 12;25(47):6262-76. Epub 2006 May 15.

PMID:
16702958
[PubMed - indexed for MEDLINE]
6.

Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif.

Moretti S, De Falco V, Tamburrino A, Barbi F, Tavano M, Avenia N, Santeusanio F, Santoro M, Macchiarulo A, Puxeddu E.

Biochim Biophys Acta. 2009 Nov;1793(11):1634-45. doi: 10.1016/j.bbamcr.2009.09.001. Epub 2009 Sep 6.

PMID:
19735675
[PubMed - indexed for MEDLINE]
Free Article
7.

Computational study on the interaction of N1 substituted pyrazole derivatives with B-raf kinase: an unusual water wire hydrogen-bond network and novel interactions at the entrance of the active site.

Alzate-Morales JH, Vergara-Jaque A, Caballero J.

J Chem Inf Model. 2010 Jun 28;50(6):1101-12. doi: 10.1021/ci100049h.

PMID:
20524689
[PubMed - indexed for MEDLINE]
8.

Molecular dynamics simulation, free energy calculation and structure-based 3D-QSAR studies of B-RAF kinase inhibitors.

Yang Y, Qin J, Liu H, Yao X.

J Chem Inf Model. 2011 Mar 28;51(3):680-92. doi: 10.1021/ci100427j. Epub 2011 Feb 22.

PMID:
21338122
[PubMed - indexed for MEDLINE]
9.

Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation.

Ikenoue T, Hikiba Y, Kanai F, Aragaki J, Tanaka Y, Imamura J, Imamura T, Ohta M, Ijichi H, Tateishi K, Kawakami T, Matsumura M, Kawabe T, Omata M.

Cancer Res. 2004 May 15;64(10):3428-35.

PMID:
15150094
[PubMed - indexed for MEDLINE]
Free Article
10.

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.

Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R; Cancer Genome Project.

Cell. 2004 Mar 19;116(6):855-67.

PMID:
15035987
[PubMed - indexed for MEDLINE]
Free Article
11.

A dimerization-dependent mechanism drives RAF catalytic activation.

Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M.

Nature. 2009 Sep 24;461(7263):542-5. doi: 10.1038/nature08314. Epub 2009 Sep 2.

PMID:
19727074
[PubMed - indexed for MEDLINE]
12.

Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.

Ikenoue T, Hikiba Y, Kanai F, Tanaka Y, Imamura J, Imamura T, Ohta M, Ijichi H, Tateishi K, Kawakami T, Aragaki J, Matsumura M, Kawabe T, Omata M.

Cancer Res. 2003 Dec 1;63(23):8132-7.

PMID:
14678966
[PubMed - indexed for MEDLINE]
Free Article
13.
14.

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

Garnett MJ, Rana S, Paterson H, Barford D, Marais R.

Mol Cell. 2005 Dec 22;20(6):963-9.

PMID:
16364920
[PubMed - indexed for MEDLINE]
Free Article
15.

Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers.

Ikenoue T, Kanai F, Hikiba Y, Tanaka Y, Imamura J, Ohta M, Jazag A, Guleng B, Asaoka Y, Tateishi K, Kawakami T, Matsumura M, Kawabe T, Omata M.

Mol Carcinog. 2005 May;43(1):59-63.

PMID:
15791648
[PubMed - indexed for MEDLINE]
16.

Identification of residues and domains of Raf important for function in vivo and in vitro.

Harding A, Hsu V, Kornfeld K, Hancock JF.

J Biol Chem. 2003 Nov 14;278(46):45519-27. Epub 2003 Sep 3.

PMID:
12954633
[PubMed - indexed for MEDLINE]
Free Article
17.

Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.

Dixit A, Torkamani A, Schork NJ, Verkhivker G.

Biophys J. 2009 Feb;96(3):858-74. doi: 10.1016/j.bpj.2008.10.041.

PMID:
19186126
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Raf proteins and cancer: B-Raf is identified as a mutational target.

Mercer KE, Pritchard CA.

Biochim Biophys Acta. 2003 Jun 5;1653(1):25-40. Review.

PMID:
12781369
[PubMed - indexed for MEDLINE]
Free Article
19.

RAF protein-serine/threonine kinases: structure and regulation.

Roskoski R Jr.

Biochem Biophys Res Commun. 2010 Aug 27;399(3):313-7. doi: 10.1016/j.bbrc.2010.07.092. Epub 2010 Jul 30. Review.

PMID:
20674547
[PubMed - indexed for MEDLINE]
20.

Detailed conformational dynamics of juxtamembrane region and activation loop in c-Kit kinase activation process.

Zou J, Wang YD, Ma FX, Xiang ML, Shi B, Wei YQ, Yang SY.

Proteins. 2008 Jul;72(1):323-32. doi: 10.1002/prot.21928.

PMID:
18214972
[PubMed - indexed for MEDLINE]

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