Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 157

1.

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM.

J Neurosci. 2009 Jul 15;29(28):9078-89. doi: 10.1523/JNEUROSCI.1071-09.2009.

PMID:
19605645
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

(-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus.

Jia N, Han K, Kong JJ, Zhang XM, Sha S, Ren GR, Cao YP.

Mol Cell Biochem. 2013 Aug;380(1-2):211-8. doi: 10.1007/s11010-013-1675-x. Epub 2013 May 10.

PMID:
23660953
[PubMed - indexed for MEDLINE]
3.

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG.

J Clin Invest. 2012 Apr 2;122(4):1339-53. doi: 10.1172/JCI57256.

PMID:
22476196
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease.

Lebbadi M, Julien C, Phivilay A, Tremblay C, Emond V, Kang JX, Calon F.

J Alzheimers Dis. 2011;27(4):853-69. doi: 10.3233/JAD-2011-111010.

PMID:
21914946
[PubMed - indexed for MEDLINE]
5.

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

Savage MJ, Lin YG, Ciallella JR, Flood DG, Scott RW.

J Neurosci. 2002 May 1;22(9):3376-85.

PMID:
11978814
[PubMed - indexed for MEDLINE]
Free Article
6.

High dietary consumption of trans fatty acids decreases brain docosahexaenoic acid but does not alter amyloid-beta and tau pathologies in the 3xTg-AD model of Alzheimer's disease.

Phivilay A, Julien C, Tremblay C, Berthiaume L, Julien P, Giguère Y, Calon F.

Neuroscience. 2009 Mar 3;159(1):296-307. doi: 10.1016/j.neuroscience.2008.12.006. Epub 2008 Dec 14.

PMID:
19135506
[PubMed - indexed for MEDLINE]
7.

Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease.

Wan J, Fu AK, Ip FC, Ng HK, Hugon J, Page G, Wang JH, Lai KO, Wu Z, Ip NY.

J Neurosci. 2010 May 19;30(20):6873-81. doi: 10.1523/JNEUROSCI.0519-10.2010.

PMID:
20484629
[PubMed - indexed for MEDLINE]
Free Article
8.

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.

Onishi T, Iwashita H, Uno Y, Kunitomo J, Saitoh M, Kimura E, Fujita H, Uchiyama N, Kori M, Takizawa M.

J Neurochem. 2011 Dec;119(6):1330-40. doi: 10.1111/j.1471-4159.2011.07532.x. Epub 2011 Nov 2.

PMID:
21992552
[PubMed - indexed for MEDLINE]
9.

β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models.

Wang D, Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S, Xiang YK.

J Biol Chem. 2013 Apr 12;288(15):10298-307. doi: 10.1074/jbc.M112.415141. Epub 2013 Feb 19.

PMID:
23430246
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
11.

Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.

Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J.

Mol Endocrinol. 2004 Aug;18(8):2024-34. Epub 2004 May 13.

PMID:
15143153
[PubMed - indexed for MEDLINE]
12.

The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

Long-Smith CM, Manning S, McClean PL, Coakley MF, O'Halloran DJ, Holscher C, O'Neill C.

Neuromolecular Med. 2013 Mar;15(1):102-14. doi: 10.1007/s12017-012-8199-5. Epub 2012 Sep 21.

PMID:
23011726
[PubMed - indexed for MEDLINE]
13.

Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice.

España J, Giménez-Llort L, Valero J, Miñano A, Rábano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA.

Biol Psychiatry. 2010 Mar 15;67(6):513-21. doi: 10.1016/j.biopsych.2009.06.015. Epub 2009 Aug 7.

PMID:
19664757
[PubMed - indexed for MEDLINE]
14.

Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines.

Zempel H, Thies E, Mandelkow E, Mandelkow EM.

J Neurosci. 2010 Sep 8;30(36):11938-50. doi: 10.1523/JNEUROSCI.2357-10.2010. Erratum in: J Neurosci. 2012 Apr 25;32(17):6052.

PMID:
20826658
[PubMed - indexed for MEDLINE]
Free Article
15.

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.

Li J, Deng J, Sheng W, Zuo Z.

Pharmacol Biochem Behav. 2012 Jun;101(4):564-74. doi: 10.1016/j.pbb.2012.03.002. Epub 2012 Mar 9.

PMID:
22425595
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer's transgenic mice.

Arendash GW, Jensen MT, Salem N Jr, Hussein N, Cracchiolo J, Dickson A, Leighty R, Potter H.

Neuroscience. 2007 Oct 26;149(2):286-302. Epub 2007 Aug 14.

PMID:
17904756
[PubMed - indexed for MEDLINE]
17.

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation.

Mairet-Coello G, Courchet J, Pieraut S, Courchet V, Maximov A, Polleux F.

Neuron. 2013 Apr 10;78(1):94-108. doi: 10.1016/j.neuron.2013.02.003.

PMID:
23583109
[PubMed - indexed for MEDLINE]
Free PMC Article
18.
19.

Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.

Minami SS, Clifford TG, Hoe HS, Matsuoka Y, Rebeck GW.

Neurobiol Aging. 2012 Apr;33(4):825.e15-24. doi: 10.1016/j.neurobiolaging.2011.05.014. Epub 2011 Jul 7.

PMID:
21741124
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG.

Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.

PMID:
24315369
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk