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Results: 1 to 20 of 165

1.

Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.

Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE.

J Pharmacol Exp Ther. 2009 Oct;331(1):45-53. doi: 10.1124/jpet.109.155630. Epub 2009 Jul 10.

PMID:
19592665
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.

Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL.

J Am Chem Soc. 2006 Dec 27;128(51):16720-32.

PMID:
17177422
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors.

Connor JH, Kleeman T, Barik S, Honkanen RE, Shenolikar S.

J Biol Chem. 1999 Aug 6;274(32):22366-72.

PMID:
10428807
[PubMed - indexed for MEDLINE]
Free Article
4.

Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition.

Buck SB, Hardouin C, Ichikawa S, Soenen DR, Gauss CM, Hwang I, Swingle MR, Bonness KM, Honkanen RE, Boger DL.

J Am Chem Soc. 2003 Dec 24;125(51):15694-5.

PMID:
14677930
[PubMed - indexed for MEDLINE]
5.

The predicted beta12-beta13 loop is important for inhibition of PP2Acalpha by the antitumor drug fostriecin.

Evans DR, Simon JA.

FEBS Lett. 2001 Jun 1;498(1):110-5.

PMID:
11389908
[PubMed - indexed for MEDLINE]
Free Article
6.

Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death.

Theobald B, Bonness K, Musiyenko A, Andrews JF, Urban G, Huang X, Dean NM, Honkanen RE.

Mol Cancer Res. 2013 Aug;11(8):845-55. doi: 10.1158/1541-7786.MCR-13-0032. Epub 2013 May 13.

PMID:
23671329
[PubMed - indexed for MEDLINE]
Free PMC Article
7.
8.

Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells.

Messner DJ, Romeo C, Boynton A, Rossie S.

J Cell Biochem. 2006 Sep 1;99(1):241-55.

PMID:
16598789
[PubMed - indexed for MEDLINE]
9.

Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues.

Bialy L, Waldmann H.

Chemistry. 2004 Jun 7;10(11):2759-80.

PMID:
15195307
[PubMed - indexed for MEDLINE]
10.

Fostriecin: chemistry and biology.

Lewy DS, Gauss CM, Soenen DR, Boger DL.

Curr Med Chem. 2002 Nov;9(22):2005-32. Review.

PMID:
12369868
[PubMed - indexed for MEDLINE]
11.

Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1.

Chen S, Kesler CT, Paschal BM, Balk SP.

J Biol Chem. 2009 Sep 18;284(38):25576-84. doi: 10.1074/jbc.M109.043133. Epub 2009 Jul 21.

PMID:
19622840
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Antitumor antibiotic fostriecin covalently binds to cysteine-269 residue of protein phosphatase 2A catalytic subunit in mammalian cells.

Takeuchi T, Takahashi N, Ishi K, Kusayanagi T, Kuramochi K, Sugawara F.

Bioorg Med Chem. 2009 Dec 1;17(23):8113-22. doi: 10.1016/j.bmc.2009.09.050. Epub 2009 Oct 3.

PMID:
19857968
[PubMed - indexed for MEDLINE]
13.

Protein phosphatase 1 regulation by inhibitors and targeting subunits.

Watanabe T, Huang HB, Horiuchi A, da Cruze Silva EF, Hsieh-Wilson L, Allen PB, Shenolikar S, Greengard P, Nairn AC.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3080-5.

PMID:
11248035
[PubMed - indexed for MEDLINE]
Free PMC Article
14.
15.

Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.

Haeseleer F, Sokal I, Gregory FD, Lee A.

Invest Ophthalmol Vis Sci. 2013 Feb 1;54(2):1214-26. doi: 10.1167/iovs.12-11319.

PMID:
23341017
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The beta12-beta13 loop of protein phosphatase-1 is involved in activity regulation.

Xie X, Xue C, Huang W, Wei Q.

IUBMB Life. 2006 Aug;58(8):487-92.

PMID:
16916787
[PubMed - indexed for MEDLINE]
17.

Epigallocatechin-3-gallate and penta-O-galloyl-β-D-glucose inhibit protein phosphatase-1.

Kiss A, Bécsi B, Kolozsvári B, Komáromi I, Kövér KE, Erdődi F.

FEBS J. 2013 Jan;280(2):612-26. doi: 10.1111/j.1742-4658.2012.08498.x. Epub 2012 Feb 13.

PMID:
22260360
[PubMed - indexed for MEDLINE]
18.

The effect of deleting residue C269 in the β12-β13 loop of protein phosphatase 2A (PP2A)catalytic subunit on the interaction between PP2A and metal ions, especially Mn(2+).

Li H, Liu C, Zhang H, Wei Q.

Biochim Biophys Acta. 2011 Dec;1814(12):1769-74. doi: 10.1016/j.bbapap.2011.09.009. Epub 2011 Oct 5.

PMID:
21996587
[PubMed - indexed for MEDLINE]
19.

Protein phosphatases regulate DNA-dependent protein kinase activity.

Douglas P, Moorhead GB, Ye R, Lees-Miller SP.

J Biol Chem. 2001 Jun 1;276(22):18992-8. Epub 2001 Mar 16.

PMID:
11376007
[PubMed - indexed for MEDLINE]
Free Article
20.

Characterization of the inhibition of protein phosphatase-1 by DARPP-32 and inhibitor-2.

Huang HB, Horiuchi A, Watanabe T, Shih SR, Tsay HJ, Li HC, Greengard P, Nairn AC.

J Biol Chem. 1999 Mar 19;274(12):7870-8.

PMID:
10075680
[PubMed - indexed for MEDLINE]
Free Article

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