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Results: 1 to 20 of 668

1.

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A.

J Biol Chem. 2009 Sep 4;284(36):24192-203. doi: 10.1074/jbc.M109.023044. Epub 2009 Jul 10.

PMID:
19592497
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4.

Mansell A, Brint E, Gould JA, O'Neill LA, Hertzog PJ.

J Biol Chem. 2004 Sep 3;279(36):37227-30. Epub 2004 Jul 9.

PMID:
15247281
[PubMed - indexed for MEDLINE]
Free Article
3.

Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

Andreakos E, Sacre SM, Smith C, Lundberg A, Kiriakidis S, Stonehouse T, Monaco C, Feldmann M, Foxwell BM.

Blood. 2004 Mar 15;103(6):2229-37. Epub 2003 Nov 20.

PMID:
14630816
[PubMed - indexed for MEDLINE]
Free Article
4.

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.

Nagpal K, Plantinga TS, Wong J, Monks BG, Gay NJ, Netea MG, Fitzgerald KA, Golenbock DT.

J Biol Chem. 2009 Sep 18;284(38):25742-8. doi: 10.1074/jbc.M109.014886. Epub 2009 Jun 9.

PMID:
19509286
[PubMed - indexed for MEDLINE]
Free PMC Article
5.
6.

TRAF6 protein couples Toll-like receptor 4 signaling to Src family kinase activation and opening of paracellular pathway in human lung microvascular endothelia.

Liu A, Gong P, Hyun SW, Wang KZ, Cates EA, Perkins D, Bannerman DD, Puché AC, Toshchakov VY, Fang S, Auron PE, Vogel SN, Goldblum SE.

J Biol Chem. 2012 May 11;287(20):16132-45. doi: 10.1074/jbc.M111.310102. Epub 2012 Mar 23.

PMID:
22447928
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan.

Doz E, Rose S, Nigou J, Gilleron M, Puzo G, Erard F, Ryffel B, Quesniaux VF.

J Biol Chem. 2007 Sep 7;282(36):26014-25. Epub 2007 Jul 6.

PMID:
17617634
[PubMed - indexed for MEDLINE]
Free Article
8.

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

Miggin SM, Pålsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, Murphy C, Moynagh P, Yamamoto M, Akira S, Rothwell N, Golenbock D, Fitzgerald KA, O'Neill LA.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3372-7. Epub 2007 Feb 20. Erratum in: Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17600.

PMID:
17360653
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Mal mediates TLR-induced activation of CREB and expression of IL-10.

Mellett M, Atzei P, Jackson R, O'Neill LA, Moynagh PN.

J Immunol. 2011 Apr 15;186(8):4925-35. doi: 10.4049/jimmunol.1002739. Epub 2011 Mar 11.

PMID:
21398611
[PubMed - indexed for MEDLINE]
Free Article
10.

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.

Nature. 2002 Nov 21;420(6913):324-9.

PMID:
12447441
[PubMed - indexed for MEDLINE]
11.

Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components.

Dobrovolskaia MA, Medvedev AE, Thomas KE, Cuesta N, Toshchakov V, Ren T, Cody MJ, Michalek SM, Rice NR, Vogel SN.

J Immunol. 2003 Jan 1;170(1):508-19.

PMID:
12496438
[PubMed - indexed for MEDLINE]
Free Article
12.

The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors.

Faisal A, Saurin A, Gregory B, Foxwell B, Parker PJ.

J Biol Chem. 2008 Jul 4;283(27):18591-600. doi: 10.1074/jbc.M710330200. Epub 2008 May 5.

PMID:
18458086
[PubMed - indexed for MEDLINE]
Free Article
13.

Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.

Loniewski KJ, Patial S, Parameswaran N.

Mol Immunol. 2007 Jul;44(15):3715-23. Epub 2007 May 15.

PMID:
17507094
[PubMed - indexed for MEDLINE]
14.

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection.

Valkov E, Stamp A, Dimaio F, Baker D, Verstak B, Roversi P, Kellie S, Sweet MJ, Mansell A, Gay NJ, Martin JL, Kobe B.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14879-84. doi: 10.1073/pnas.1104780108. Epub 2011 Aug 22.

PMID:
21873236
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.

Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA.

Nature. 2001 Sep 6;413(6851):78-83.

PMID:
11544529
[PubMed - indexed for MEDLINE]
17.

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

Jiang Z, Mak TW, Sen G, Li X.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3533-8. Epub 2004 Feb 24.

PMID:
14982987
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T.

J Biol Chem. 2003 Dec 12;278(50):49751-62. Epub 2003 Sep 30.

PMID:
14519765
[PubMed - indexed for MEDLINE]
Free Article
19.

Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.

Hise AG, Daehnel K, Gillette-Ferguson I, Cho E, McGarry HF, Taylor MJ, Golenbock DT, Fitzgerald KA, Kazura JW, Pearlman E.

J Immunol. 2007 Jan 15;178(2):1068-76.

PMID:
17202370
[PubMed - indexed for MEDLINE]
Free Article
20.

A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.

Sweeney TE, Suliman HB, Hollingsworth JW, Welty-Wolf KE, Piantadosi CA.

PLoS One. 2011;6(9):e25249. doi: 10.1371/journal.pone.0025249. Epub 2011 Sep 26.

PMID:
21966468
[PubMed - indexed for MEDLINE]
Free PMC Article

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