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Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells.

Kulkarni RN.

Endocrinology. 2009 Jul;150(7):2994-6. doi: 10.1210/en.2009-0440. No abstract available.


Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion.

Robson-Doucette CA, Sultan S, Allister EM, Wikstrom JD, Koshkin V, Bhattacharjee A, Prentice KJ, Sereda SB, Shirihai OS, Wheeler MB.

Diabetes. 2011 Nov;60(11):2710-9. doi: 10.2337/db11-0132. Epub 2011 Oct 7.


Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function.

Pi J, Collins S.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:141-8. doi: 10.1111/j.1463-1326.2010.01269.x. Review.


Mitochondrial uncoupling protein 2 in pancreatic β-cells.

Brand MD, Parker N, Affourtit C, Mookerjee SA, Azzu V.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:134-40. doi: 10.1111/j.1463-1326.2010.01264.x. Review.


Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, Bécard D, Gjinovci A, Keller PA, Wollheim CB, Herrera P, Muzzin P, Assimacopoulos-Jeannet F.

Diabetologia. 2007 Jan;50(1):84-93. Epub 2006 Nov 28.


Role and mechanism of uncoupling protein 2 on the fatty acid-induced dysfunction of pancreatic alpha cells in vitro.

Su JY, Li HL, Yang WY, Xiao JZ, Du RQ, Shen XX, Cai Z, Zhang L, Shu J.

Chin Med J (Engl). 2010 Sep;123(17):2416-23.


Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species.

Affourtit C, Jastroch M, Brand MD.

Free Radic Biol Med. 2011 Mar 1;50(5):609-16. doi: 10.1016/j.freeradbiomed.2010.12.020. Epub 2010 Dec 21.


Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action.

De Souza CT, Araújo EP, Stoppiglia LF, Pauli JR, Ropelle E, Rocco SA, Marin RM, Franchini KG, Carvalheira JB, Saad MJ, Boschero AC, Carneiro EM, Velloso LA.

FASEB J. 2007 Apr;21(4):1153-63. Epub 2007 Jan 5.


Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: new evidence for a putative novel function of uncoupling proteins as superoxide anion transporters.

Suski JM, Schönfeld P, Bonora M, Shabalina I, Pinton P, Więckowski MR.

Biochem Biophys Res Commun. 2012 Nov 16;428(2):234-8. doi: 10.1016/j.bbrc.2012.10.025. Epub 2012 Oct 12.


Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin.

Lee SC, Robson-Doucette CA, Wheeler MB.

J Endocrinol. 2009 Oct;203(1):33-43. doi: 10.1677/JOE-09-0117. Epub 2009 Jul 27.


[Mitochondrial uncoupling protein UCP2 and cancer].

An JD, Jiang Y.

Sheng Li Ke Xue Jin Zhan. 2013 Jun;44(3):233-6. Review. Chinese. No abstract available.


Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.

Emre Y, Hurtaud C, Karaca M, Nubel T, Zavala F, Ricquier D.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19085-90. Epub 2007 Nov 15.


Modified glutamine catabolism in macrophages of Ucp2 knock-out mice.

Nübel T, Emre Y, Rabier D, Chadefaux B, Ricquier D, Bouillaud F.

Biochim Biophys Acta. 2008 Jan;1777(1):48-54. Epub 2007 Nov 12.


UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival.

Diao J, Allister EM, Koshkin V, Lee SC, Bhattacharjee A, Tang C, Giacca A, Chan CB, Wheeler MB.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12057-62. doi: 10.1073/pnas.0710434105. Epub 2008 Aug 13.


cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing beta-cells.

McQuaid TS, Saleh MC, Joseph JW, Gyulkhandanyan A, Manning-Fox JE, MacLellan JD, Wheeler MB, Chan CB.

J Endocrinol. 2006 Sep;190(3):669-80.


Coupled with uncouplers: the curious case of lifespan.

Lockie SH, Müller TD, Tschöp MH.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E619-20. doi: 10.1152/ajpendo.00060.2009. Epub 2009 Feb 10. No abstract available.


[Uncoupling protein-2 and nonalcoholic fatty liver].

Dai DL, Shen W.

Zhonghua Gan Zang Bing Za Zhi. 2004 Sep;12(9):574-6. Review. Chinese. No abstract available.


UCPs--unlikely calcium porters.

Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ, Brand MD.

Nat Cell Biol. 2008 Nov;10(11):1235-7; author reply 1237-40. doi: 10.1038/ncb1108-1235. No abstract available.


Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells.

Wan J, Jiang L, Lü Q, Ke L, Li X, Tong N.

Biochem Biophys Res Commun. 2010 Jan 15;391(3):1567-72. doi: 10.1016/j.bbrc.2009.12.127. Epub 2009 Dec 27.


Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization.

Pecqueur C, Bui T, Gelly C, Hauchard J, Barbot C, Bouillaud F, Ricquier D, Miroux B, Thompson CB.

FASEB J. 2008 Jan;22(1):9-18. Epub 2007 Sep 13.

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