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Results: 1 to 20 of 125

1.

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody.

Sinha S, Zhang L, Duan S, Williams TD, Vlasak J, Ionescu R, Topp EM.

Protein Sci. 2009 Aug;18(8):1573-84. doi: 10.1002/pro.173.

PMID:
19544580
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Asparagine deamidation dependence on buffer type, pH, and temperature.

Pace AL, Wong RL, Zhang YT, Kao YH, Wang YJ.

J Pharm Sci. 2013 Jun;102(6):1712-23. doi: 10.1002/jps.23529. Epub 2013 Apr 9.

PMID:
23568760
[PubMed - indexed for MEDLINE]
3.

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

Huang L, Lu J, Wroblewski VJ, Beals JM, Riggin RM.

Anal Chem. 2005 Mar 1;77(5):1432-9.

PMID:
15732928
[PubMed - indexed for MEDLINE]
4.

Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.

Yan B, Steen S, Hambly D, Valliere-Douglass J, Vanden Bos T, Smallwood S, Yates Z, Arroll T, Han Y, Gadgil H, Latypov RF, Wallace A, Lim A, Kleemann GR, Wang W, Balland A.

J Pharm Sci. 2009 Oct;98(10):3509-21. doi: 10.1002/jps.21655.

PMID:
19475547
[PubMed - indexed for MEDLINE]
5.

A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies.

Furlong MT, Ouyang Z, Wu S, Tamura J, Olah T, Tymiak A, Jemal M.

Biomed Chromatogr. 2012 Aug;26(8):1024-32. doi: 10.1002/bmc.2759. Epub 2012 May 24.

PMID:
22623136
[PubMed - indexed for MEDLINE]
6.

Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H(2)(18)O.

Terashima I, Koga A, Nagai H.

Anal Biochem. 2007 Sep 1;368(1):49-60. Epub 2007 May 17.

PMID:
17617368
[PubMed - indexed for MEDLINE]
7.

Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures.

Diepold K, Bomans K, Wiedmann M, Zimmermann B, Petzold A, Schlothauer T, Mueller R, Moritz B, Stracke JO, Mølhøj M, Reusch D, Bulau P.

PLoS One. 2012;7(1):e30295. doi: 10.1371/journal.pone.0030295. Epub 2012 Jan 17.

PMID:
22272329
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Traces of pFc' in IVIG interact with human IgG Fc domains and counteract aggregation.

Rispens T, Himly M, Ooievaar-De Heer P, den Bleker TH, Aalberse RC.

Eur J Pharm Sci. 2010 Apr 16;40(1):62-8. doi: 10.1016/j.ejps.2010.03.001. Epub 2010 Mar 6. Erratum in: Eur J Pharm Sci. 2011 Jan 18;42(1-2):164.

PMID:
20211252
[PubMed - indexed for MEDLINE]
9.

Glutamine deamidation of a recombinant monoclonal antibody.

Liu H, Gaza-Bulseco G, Chumsae C.

Rapid Commun Mass Spectrom. 2008 Dec;22(24):4081-8. doi: 10.1002/rcm.3831.

PMID:
19021137
[PubMed - indexed for MEDLINE]
10.

Degradation products analysis of an Fc fusion protein using LC/MS methods.

Ren D, Ratnaswamy G, Beierle J, Treuheit MJ, Brems DN, Bondarenko PV.

Int J Biol Macromol. 2009 Jan 1;44(1):81-5. doi: 10.1016/j.ijbiomac.2008.10.006. Epub 2008 Oct 30.

PMID:
19014964
[PubMed - indexed for MEDLINE]
11.

Characterization of glycosylation sites for a recombinant IgG1 monoclonal antibody and a CTLA4-Ig fusion protein by liquid chromatography-mass spectrometry peptide mapping.

Bongers J, Devincentis J, Fu J, Huang P, Kirkley DH, Leister K, Liu P, Ludwig R, Rumney K, Tao L, Wu W, Russell RJ.

J Chromatogr A. 2011 Nov 11;1218(45):8140-9. doi: 10.1016/j.chroma.2011.08.089. Epub 2011 Sep 3.

PMID:
21978954
[PubMed - indexed for MEDLINE]
12.

Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis.

Gadgil HS, Bondarenko PV, Pipes GD, Dillon TM, Banks D, Abel J, Kleemann GR, Treuheit MJ.

Anal Biochem. 2006 Aug 15;355(2):165-74. Epub 2006 Jun 15.

PMID:
16828048
[PubMed - indexed for MEDLINE]
13.

Human antibody Fc deamidation in vivo.

Liu YD, van Enk JZ, Flynn GC.

Biologicals. 2009 Oct;37(5):313-22. doi: 10.1016/j.biologicals.2009.06.001. Epub 2009 Jul 15.

PMID:
19608432
[PubMed - indexed for MEDLINE]
14.

Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation.

Liu D, Ren D, Huang H, Dankberg J, Rosenfeld R, Cocco MJ, Li L, Brems DN, Remmele RL Jr.

Biochemistry. 2008 May 6;47(18):5088-100. doi: 10.1021/bi702238b. Epub 2008 Apr 12.

PMID:
18407665
[PubMed - indexed for MEDLINE]
15.

Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry.

Lehmann WD, Schlosser A, Erben G, Pipkorn R, Bossemeyer D, Kinzel V.

Protein Sci. 2000 Nov;9(11):2260-8.

PMID:
11152137
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

Suzuki T, Ishii-Watabe A, Tada M, Kobayashi T, Kanayasu-Toyoda T, Kawanishi T, Yamaguchi T.

J Immunol. 2010 Feb 15;184(4):1968-76. doi: 10.4049/jimmunol.0903296. Epub 2010 Jan 18.

PMID:
20083659
[PubMed - indexed for MEDLINE]
Free Article
17.

Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry.

Houde D, Arndt J, Domeier W, Berkowitz S, Engen JR.

Anal Chem. 2009 Apr 1;81(7):2644-51. doi: 10.1021/ac802575y. Erratum in: Anal Chem. 2009 Jul 15;81(14):5966.

PMID:
19265386
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells.

Hills AE, Patel A, Boyd P, James DC.

Biotechnol Bioeng. 2001 Oct 20;75(2):239-51.

PMID:
11536148
[PubMed - indexed for MEDLINE]
19.

Sequence-specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides.

Sargaeva NP, Goloborodko AA, O'Connor PB, Moskovets E, Gorshkov MV.

Electrophoresis. 2011 Aug;32(15):1962-9. doi: 10.1002/elps.201000507. Epub 2011 May 9.

PMID:
21557257
[PubMed - indexed for MEDLINE]
20.

Quantitative analysis of deamidation and isomerization in β2-microglobulin by 18O labeling.

Fukuda M, Takao T.

Anal Chem. 2012 Dec 4;84(23):10388-94. doi: 10.1021/ac302603b. Epub 2012 Nov 14.

PMID:
23126476
[PubMed - indexed for MEDLINE]

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