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Results: 1 to 20 of 861

1.

Discovery and potency optimization of 2-amino-5-arylmethyl-1,3-thiazole derivatives as potential therapeutic agents for prostate cancer.

Krasavin M, Karapetian R, Konstantinov I, Gezentsvey Y, Bukhryakov K, Godovykh E, Soldatkina O, Lavrovsky Y, Sosnov AV, Gakh AA.

Arch Pharm (Weinheim). 2009 Jul;342(7):420-7. doi: 10.1002/ardp.200800201.

PMID:
19544302
[PubMed - indexed for MEDLINE]
2.

Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer.

Krasavin M, Rufanov KA, Sosnov AV, Karapetian R, Godovykh E, Soldatkina O, Lavrovsky Y, Gakh AA.

Chem Cent J. 2010 Mar 9;4:4. doi: 10.1186/1752-153X-4-4.

PMID:
20214785
[PubMed]
Free PMC Article
3.

Synthesis and antiproliferative activity of 2-aryl-4-oxo-thiazolidin-3-yl-amides for prostate cancer.

Gududuru V, Hurh E, Dalton JT, Miller DD.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5289-93.

PMID:
15454213
[PubMed - indexed for MEDLINE]
4.

2-(3-Amino-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide: a new tiazofurin analogue with potent antitumour activity.

Popsavin M, Spaić S, Svircev M, Kojić V, Bogdanović G, Popsavin V.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5317-20.

PMID:
16908146
[PubMed - indexed for MEDLINE]
5.

Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer.

Gududuru V, Hurh E, Dalton JT, Miller DD.

J Med Chem. 2005 Apr 7;48(7):2584-8.

PMID:
15801848
[PubMed - indexed for MEDLINE]
6.

New imidazo[2,1-b]thiazole derivatives: synthesis, in vitro anticancer evaluation, and in silico studies.

Park JH, El-Gamal MI, Lee YS, Oh CH.

Eur J Med Chem. 2011 Dec;46(12):5769-77. doi: 10.1016/j.ejmech.2011.08.024. Epub 2011 Aug 23.

PMID:
22033063
[PubMed - indexed for MEDLINE]
7.

New thiazole carboxamides as potent inhibitors of Akt kinases.

Chang S, Zhang Z, Zhuang X, Luo J, Cao X, Li H, Tu Z, Lu X, Ren X, Ding K.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1208-12. doi: 10.1016/j.bmcl.2011.11.080. Epub 2011 Nov 30.

PMID:
22172705
[PubMed - indexed for MEDLINE]
8.

Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.

Andrews DM, Stokes ES, Carr GR, Matusiak ZS, Roberts CA, Waring MJ, Brady MC, Chresta CM, East SJ.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2580-4. doi: 10.1016/j.bmcl.2008.03.041. Epub 2008 Mar 16.

PMID:
18378449
[PubMed - indexed for MEDLINE]
9.

Synthesis and primary cytotoxicity evaluation of new imidazo[2,1-b]thiazole derivatives.

Gürsoy E, Güzeldemirci NU.

Eur J Med Chem. 2007 Mar;42(3):320-6. Epub 2006 Dec 4.

PMID:
17145120
[PubMed - indexed for MEDLINE]
10.

Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds.

Hou Z, Nakanishi I, Kinoshita T, Takei Y, Yasue M, Misu R, Suzuki Y, Nakamura S, Kure T, Ohno H, Murata K, Kitaura K, Hirasawa A, Tsujimoto G, Oishi S, Fujii N.

J Med Chem. 2012 Mar 22;55(6):2899-903. doi: 10.1021/jm2015167. Epub 2012 Mar 7.

PMID:
22339433
[PubMed - indexed for MEDLINE]
11.

The design, synthesis and anticancer activity of new nitrogen mustard derivatives of natural indole phytoalexin 1-methoxyspirobrassinol.

Mezencev R, Kutschy P, Salayova A, Updegrove T, McDonald JF.

Neoplasma. 2009;56(4):321-30.

PMID:
19473057
[PubMed - indexed for MEDLINE]
12.

New antitumor imidazo[2,1-b]thiazole guanylhydrazones and analogues.

Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Farruggia G, Zini M, Stefanelli C, Masotti L, Radin NS, Shoemaker RH.

J Med Chem. 2008 Feb 28;51(4):809-16. doi: 10.1021/jm701246g. Epub 2008 Feb 6.

PMID:
18251494
[PubMed - indexed for MEDLINE]
13.

Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline.

Andreani A, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Lenaz G, Fato R, Bergamini C, Farruggia G.

J Med Chem. 2005 Apr 21;48(8):3085-9.

PMID:
15828848
[PubMed - indexed for MEDLINE]
14.

Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancers cells.

Zeng X, Yin B, Hu Z, Liao C, Liu J, Li S, Li Z, Nicklaus MC, Zhou G, Jiang S.

Org Lett. 2010 Mar 19;12(6):1368-71. doi: 10.1021/ol100308a.

PMID:
20184338
[PubMed - indexed for MEDLINE]
15.

Drug design and testing: profiling of antiproliferative agents for cancer therapy using a cell-based methyl-[3H]-thymidine incorporation assay.

Griffiths M, Sundaram H.

Methods Mol Biol. 2011;731:451-65. doi: 10.1007/978-1-61779-080-5_36.

PMID:
21516428
[PubMed - indexed for MEDLINE]
16.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Wang Y, Zhao J, Jia S, Herich J, Labreque D, Storer R, Meerovitch K, Bouffard D, Rej R, Denis R, Blais C, Lamothe S, Attardo G, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2004 Dec 2;47(25):6299-310.

PMID:
15566300
[PubMed - indexed for MEDLINE]
17.

Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives.

Cai J, Zhang S, Zheng M, Wu X, Chen J, Ji M.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):806-10. doi: 10.1016/j.bmcl.2011.12.070. Epub 2011 Dec 20.

PMID:
22217877
[PubMed - indexed for MEDLINE]
18.

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents.

Lv PC, Li DD, Li QS, Lu X, Xiao ZP, Zhu HL.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5374-7. doi: 10.1016/j.bmcl.2011.07.010. Epub 2011 Jul 14.

PMID:
21802290
[PubMed - indexed for MEDLINE]
19.

Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines.

Dourlat J, Liu WQ, Gresh N, Garbay C.

Bioorg Med Chem Lett. 2007 May 1;17(9):2527-30. Epub 2007 Feb 9.

PMID:
17317183
[PubMed - indexed for MEDLINE]
20.

Microwave-assisted synthesis of novel thiazolocarbazoles and evaluation as potential anticancer agents. Part III.

Testard A, Picot L, Fruitier-Arnaudin I, Piot JM, Chabane H, Domon L, Thiery V, Besson T.

J Enzyme Inhib Med Chem. 2004 Dec;19(6):467-73.

PMID:
15662950
[PubMed - indexed for MEDLINE]

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