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Results: 1 to 20 of 261

1.

A highly active single-mutation variant of P450BM3 (CYP102A1).

Whitehouse CJ, Bell SG, Yang W, Yorke JA, Blanford CF, Strong AJ, Morse EJ, Bartlam M, Rao Z, Wong LL.

Chembiochem. 2009 Jul 6;10(10):1654-6. doi: 10.1002/cbic.200900279.

PMID:
19492389
[PubMed - indexed for MEDLINE]
2.

Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.

Park SH, Kim DH, Kim D, Kim DH, Jung HC, Pan JG, Ahn T, Kim D, Yun CH.

Drug Metab Dispos. 2010 May;38(5):732-9. doi: 10.1124/dmd.109.030759. Epub 2010 Jan 25.

PMID:
20100815
[PubMed - indexed for MEDLINE]
Free Article
3.

Novel haem co-ordination variants of flavocytochrome P450BM3.

Girvan HM, Toogood HS, Littleford RE, Seward HE, Smith WE, Ekanem IS, Leys D, Cheesman MR, Munro AW.

Biochem J. 2009 Jan 1;417(1):65-76. doi: 10.1042/BJ20081133.

PMID:
18721129
[PubMed - indexed for MEDLINE]
Free Article
4.

Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene omega-hydroxylase CYP4C7.

Chen CK, Berry RE, Shokhireva TKh, Murataliev MB, Zhang H, Walker FA.

J Biol Inorg Chem. 2010 Feb;15(2):159-74. doi: 10.1007/s00775-009-0580-y. Epub 2009 Aug 30.

PMID:
19727859
[PubMed - indexed for MEDLINE]
5.
6.

Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variant.

Whitehouse CJ, Yang W, Yorke JA, Tufton HG, Ogilvie LC, Bell SG, Zhou W, Bartlam M, Rao Z, Wong LL.

Dalton Trans. 2011 Oct 28;40(40):10383-96. doi: 10.1039/c1dt10098j. Epub 2011 May 20.

PMID:
21603690
[PubMed - indexed for MEDLINE]
7.

The effect of mutation of F87 on the properties of CYP102A1-CYP4C7 chimeras: altered regiospecificity and substrate selectivity.

Chen CK, Shokhireva TKh, Berry RE, Zhang H, Walker FA.

J Biol Inorg Chem. 2008 Jun;13(5):813-24. doi: 10.1007/s00775-008-0368-5. Epub 2008 Apr 8.

PMID:
18392864
[PubMed - indexed for MEDLINE]
8.

Structural basis for the properties of two single-site proline mutants of CYP102A1 (P450BM3).

Whitehouse CJ, Yang W, Yorke JA, Rowlatt BC, Strong AJ, Blanford CF, Bell SG, Bartlam M, Wong LL, Rao Z.

Chembiochem. 2010 Dec 10;11(18):2549-56. doi: 10.1002/cbic.201000421.

PMID:
21110374
[PubMed - indexed for MEDLINE]
9.

Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3.

Girvan HM, Levy CW, Williams P, Fisher K, Cheesman MR, Rigby SE, Leys D, Munro AW.

Biochem J. 2010 Apr 14;427(3):455-66. doi: 10.1042/BJ20091603.

PMID:
20180779
[PubMed - indexed for MEDLINE]
Free Article
10.

P450(BM3) (CYP102A1): connecting the dots.

Whitehouse CJ, Bell SG, Wong LL.

Chem Soc Rev. 2012 Feb 7;41(3):1218-60. doi: 10.1039/c1cs15192d. Epub 2011 Oct 18. Review.

PMID:
22008827
[PubMed - indexed for MEDLINE]
11.

Expression, purification, and characterization of Bacillus subtilis cytochromes P450 CYP102A2 and CYP102A3: flavocytochrome homologues of P450 BM3 from Bacillus megaterium.

Gustafsson MC, Roitel O, Marshall KR, Noble MA, Chapman SK, Pessegueiro A, Fulco AJ, Cheesman MR, von Wachenfeldt C, Munro AW.

Biochemistry. 2004 May 11;43(18):5474-87.

PMID:
15122913
[PubMed - indexed for MEDLINE]
12.

P450(BM3) on steroids: the Swiss Army knife P450 enzyme just gets better.

Wong LL.

Chembiochem. 2011 Nov 25;12(17):2537-9. doi: 10.1002/cbic.201100606. Epub 2011 Oct 13.

PMID:
21998091
[PubMed - indexed for MEDLINE]
13.

A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).

Dietrich JA, Yoshikuni Y, Fisher KJ, Woolard FX, Ockey D, McPhee DJ, Renninger NS, Chang MC, Baker D, Keasling JD.

ACS Chem Biol. 2009 Apr 17;4(4):261-7. doi: 10.1021/cb900006h.

PMID:
19271725
[PubMed - indexed for MEDLINE]
14.

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.

Neeli R, Girvan HM, Lawrence A, Warren MJ, Leys D, Scrutton NS, Munro AW.

FEBS Lett. 2005 Oct 24;579(25):5582-8. Epub 2005 Sep 28.

PMID:
16214136
[PubMed - indexed for MEDLINE]
Free Article
15.

Desaturation of alkylbenzenes by cytochrome P450(BM3) (CYP102A1).

Whitehouse CJ, Bell SG, Wong LL.

Chemistry. 2008;14(35):10905-8. doi: 10.1002/chem.200801927. No abstract available.

PMID:
19003834
[PubMed - indexed for MEDLINE]
16.

Kinetics and activation parameters for oxidations of styrene by Compounds I from the cytochrome P450(BM-3) (CYP102A1) heme domain and from CYP119.

Yuan X, Wang Q, Horner JH, Sheng X, Newcomb M.

Biochemistry. 2009 Sep 29;48(38):9140-6. doi: 10.1021/bi901258m.

PMID:
19708688
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer.

Girvan HM, Dunford AJ, Neeli R, Ekanem IS, Waltham TN, Joyce MG, Leys D, Curtis RA, Williams P, Fisher K, Voice MW, Munro AW.

Arch Biochem Biophys. 2011 Mar 1;507(1):75-85. doi: 10.1016/j.abb.2010.09.014. Epub 2010 Sep 22.

PMID:
20868649
[PubMed - indexed for MEDLINE]
18.

Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.

Kim DH, Kim KH, Kim DH, Liu KH, Jung HC, Pan JG, Yun CH.

Drug Metab Dispos. 2008 Nov;36(11):2166-70. doi: 10.1124/dmd.108.021220. Epub 2008 Jul 31.

PMID:
18669587
[PubMed - indexed for MEDLINE]
Free Article
19.

Identification and characterization of 4-hexylbenzoic acid and 4-nonyloxybenzoic acid as substrates of CYP102A1.

Gudiminchi RK, Smit MS.

Appl Microbiol Biotechnol. 2011 Apr;90(1):117-26. doi: 10.1007/s00253-010-3029-x. Epub 2010 Dec 16.

PMID:
21161210
[PubMed - indexed for MEDLINE]
20.

Altering the regioselectivity of the subterminal fatty acid hydroxylase P450 BM-3 towards gamma- and delta-positions.

Dietrich M, Do TA, Schmid RD, Pleiss J, Urlacher VB.

J Biotechnol. 2009 Jan 1;139(1):115-7. doi: 10.1016/j.jbiotec.2008.10.002. Epub 2008 Oct 15.

PMID:
18984016
[PubMed - indexed for MEDLINE]

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