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Results: 1 to 20 of 154

1.

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

Davies NJ, Hayden RE, Simpson PJ, Birtwistle J, Mayer K, Ride JP, Bunce CM.

Cancer Res. 2009 Jun 1;69(11):4769-75. doi: 10.1158/0008-5472.CAN-08-4533.

PMID:
19487289
[PubMed - indexed for MEDLINE]
Free Article
2.

Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria.

Rotem R, Heyfets A, Fingrut O, Blickstein D, Shaklai M, Flescher E.

Cancer Res. 2005 Mar 1;65(5):1984-93.

PMID:
15753398
[PubMed - indexed for MEDLINE]
Free Article
3.

Methyl jasmonate: a plant stress hormone as an anti-cancer drug.

Cohen S, Flescher E.

Phytochemistry. 2009 Sep;70(13-14):1600-9. doi: 10.1016/j.phytochem.2009.06.007. Epub 2009 Aug 5. Review.

PMID:
19660769
[PubMed - indexed for MEDLINE]
4.

Jasmonates--a new family of anti-cancer agents.

Flescher E.

Anticancer Drugs. 2005 Oct;16(9):911-6. Review.

PMID:
16162967
[PubMed - indexed for MEDLINE]
5.

Jasmonates in cancer therapy.

Flescher E.

Cancer Lett. 2007 Jan 8;245(1-2):1-10. Epub 2006 Apr 4. Review.

PMID:
16600475
[PubMed - indexed for MEDLINE]
6.

Methyl jasmonate binds to and detaches mitochondria-bound hexokinase.

Goldin N, Arzoine L, Heyfets A, Israelson A, Zaslavsky Z, Bravman T, Bronner V, Notcovich A, Shoshan-Barmatz V, Flescher E.

Oncogene. 2008 Aug 7;27(34):4636-43. doi: 10.1038/onc.2008.108. Epub 2008 Apr 14.

PMID:
18408762
[PubMed - indexed for MEDLINE]
7.

Natural jasmonates of different structures suppress the growth of human neuroblastoma cell line SH-SY5Y and its mechanisms.

Tong QS, Jiang GS, Zheng LD, Tang ST, Cai JB, Liu Y, Zeng FQ, Dong JH.

Acta Pharmacol Sin. 2008 Jul;29(7):861-9. doi: 10.1111/j.1745-7254.2008.00814.x.

PMID:
18565287
[PubMed - indexed for MEDLINE]
Free Article
8.

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

Marín YE, Seiberg M, Lin CB.

Exp Dermatol. 2009 Jul;18(7):611-8. doi: 10.1111/j.1600-0625.2008.00839.x. Epub 2009 Mar 6.

PMID:
19320734
[PubMed - indexed for MEDLINE]
9.

Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors.

Penning TM, Steckelbroeck S, Bauman DR, Miller MW, Jin Y, Peehl DM, Fung KM, Lin HK.

Mol Cell Endocrinol. 2006 Mar 27;248(1-2):182-91. Epub 2006 Jan 18.

PMID:
16417966
[PubMed - indexed for MEDLINE]
10.

New enzymatic assay for the AKR1C enzymes.

Beranič N, Stefane B, Brus B, Gobec S, Rižner TL.

Chem Biol Interact. 2013 Feb 25;202(1-3):204-9. doi: 10.1016/j.cbi.2012.12.003. Epub 2012 Dec 19.

PMID:
23261716
[PubMed - indexed for MEDLINE]
11.

The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis.

Birtwistle J, Hayden RE, Khanim FL, Green RM, Pearce C, Davies NJ, Wake N, Schrewe H, Ride JP, Chipman JK, Bunce CM.

Mutat Res. 2009 Mar 9;662(1-2):67-74. doi: 10.1016/j.mrfmmm.2008.12.010. Epub 2008 Dec 31.

PMID:
19162045
[PubMed - indexed for MEDLINE]
12.

New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3.

Stefane B, Brozic P, Vehovc M, Rizner TL, Gobec S.

Eur J Med Chem. 2009 Jun;44(6):2563-71. doi: 10.1016/j.ejmech.2009.01.028. Epub 2009 Feb 5.

PMID:
19237229
[PubMed - indexed for MEDLINE]
13.

Methyl jasmonate induces production of reactive oxygen species and alterations in mitochondrial dynamics that precede photosynthetic dysfunction and subsequent cell death.

Zhang L, Xing D.

Plant Cell Physiol. 2008 Jul;49(7):1092-111. doi: 10.1093/pcp/pcn086. Epub 2008 Jun 5.

PMID:
18535010
[PubMed - indexed for MEDLINE]
14.

Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily.

Steckelbroeck S, Oyesanmi B, Jin Y, Lee SH, Kloosterboer HJ, Penning TM.

J Pharmacol Exp Ther. 2006 Mar;316(3):1300-9. Epub 2005 Dec 8.

PMID:
16339391
[PubMed - indexed for MEDLINE]
Free Article
16.

Methyl jasmonate induces cell cycle block and cell death in the amitochondriate parasite Trichomonas vaginalis.

Ofer K, Gold D, Flescher E.

Int J Parasitol. 2008 Jul;38(8-9):959-68. doi: 10.1016/j.ijpara.2007.12.008. Epub 2008 Jan 26.

PMID:
18294640
[PubMed - indexed for MEDLINE]
17.

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

Ruiz FX, Porté S, Gallego O, Moro A, Ardèvol A, Del Río-Espínola A, Rovira C, Farrés J, Parés X.

Biochem J. 2011 Dec 15;440(3):335-44. doi: 10.1042/BJ20111286.

PMID:
21851338
[PubMed - indexed for MEDLINE]
Free Article
18.

Mitochondria-mediated ATP depletion by anti-cancer agents of the jasmonate family.

Goldin N, Heyfets A, Reischer D, Flescher E.

J Bioenerg Biomembr. 2007 Feb;39(1):51-7. Review.

PMID:
17549642
[PubMed - indexed for MEDLINE]
19.

Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng.

Halim M, Yee DJ, Sames D.

J Am Chem Soc. 2008 Oct 29;130(43):14123-8. doi: 10.1021/ja801245y. Epub 2008 Oct 1.

PMID:
18826220
[PubMed - indexed for MEDLINE]
20.

Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.

Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, Sakai S.

J Biochem. 1998 Nov;124(5):940-6.

PMID:
9792917
[PubMed - indexed for MEDLINE]
Free Article
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