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Results: 1 to 20 of 389

1.

The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis.

Léger M, Gavalda S, Guillet V, van der Rest B, Slama N, Montrozier H, Mourey L, Quémard A, Daffé M, Marrakchi H.

Chem Biol. 2009 May 29;16(5):510-9. doi: 10.1016/j.chembiol.2009.03.012.

PMID:
19477415
[PubMed - indexed for MEDLINE]
Free Article
2.

The acyl-AMP ligase FadD32 and AccD4-containing acyl-CoA carboxylase are required for the synthesis of mycolic acids and essential for mycobacterial growth: identification of the carboxylation product and determination of the acyl-CoA carboxylase components.

Portevin D, de Sousa-D'Auria C, Montrozier H, Houssin C, Stella A, Lanéelle MA, Bardou F, Guilhot C, Daffé M.

J Biol Chem. 2005 Mar 11;280(10):8862-74. Epub 2005 Jan 4.

PMID:
15632194
[PubMed - indexed for MEDLINE]
Free Article
3.

The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.

Gavalda S, Léger M, van der Rest B, Stella A, Bardou F, Montrozier H, Chalut C, Burlet-Schiltz O, Marrakchi H, Daffé M, Quémard A.

J Biol Chem. 2009 Jul 17;284(29):19255-64. doi: 10.1074/jbc.M109.006940. Epub 2009 May 12.

PMID:
19436070
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Assay development for identifying inhibitors of the mycobacterial FadD32 activity.

Galandrin S, Guillet V, Rane RS, Léger M, N R, Eynard N, Das K, Balganesh TS, Mourey L, Daffé M, Marrakchi H.

J Biomol Screen. 2013 Jun;18(5):576-87. doi: 10.1177/1087057112474691. Epub 2013 Jan 30.

PMID:
23364516
[PubMed - indexed for MEDLINE]
5.

The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.

Sacco E, Covarrubias AS, O'Hare HM, Carroll P, Eynard N, Jones TA, Parish T, Daffé M, Bäckbro K, Quémard A.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14628-33. Epub 2007 Sep 5.

PMID:
17804795
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB.

Schaeffer ML, Agnihotri G, Volker C, Kallender H, Brennan PJ, Lonsdale JT.

J Biol Chem. 2001 Dec 14;276(50):47029-37. Epub 2001 Oct 12.

PMID:
11600501
[PubMed - indexed for MEDLINE]
Free Article
7.

Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III.

Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT.

J Biol Chem. 2001 Jun 8;276(23):20516-22. Epub 2001 Mar 8.

PMID:
11278743
[PubMed - indexed for MEDLINE]
Free Article
8.

The biosynthesis of mycolic acids in Mycobacterium tuberculosis. Enzymatic methyl(ene) transfer to acyl carrier protein bound meromycolic acid in vitro.

Yuan Y, Mead D, Schroeder BG, Zhu Y, Barry CE 3rd.

J Biol Chem. 1998 Aug 14;273(33):21282-90.

PMID:
9694888
[PubMed - indexed for MEDLINE]
Free Article
9.

Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.

Kremer L, Dover LG, Carrère S, Nampoothiri KM, Lesjean S, Brown AK, Brennan PJ, Minnikin DE, Locht C, Besra GS.

Biochem J. 2002 Jun 1;364(Pt 2):423-30.

PMID:
12023885
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.

Kremer L, Nampoothiri KM, Lesjean S, Dover LG, Graham S, Betts J, Brennan PJ, Minnikin DE, Locht C, Besra GS.

J Biol Chem. 2001 Jul 27;276(30):27967-74. Epub 2001 May 23.

PMID:
11373295
[PubMed - indexed for MEDLINE]
Free Article
11.

Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis.

Choi KH, Kremer L, Besra GS, Rock CO.

J Biol Chem. 2000 Sep 8;275(36):28201-7.

PMID:
10840036
[PubMed - indexed for MEDLINE]
Free Article
12.

MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II.

Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffé M, Quémard A.

Microbiology. 2002 Apr;148(Pt 4):951-60.

PMID:
11932442
[PubMed - indexed for MEDLINE]
Free Article
13.

Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.

Gande R, Gibson KJ, Brown AK, Krumbach K, Dover LG, Sahm H, Shioyama S, Oikawa T, Besra GS, Eggeling L.

J Biol Chem. 2004 Oct 22;279(43):44847-57. Epub 2004 Aug 11.

PMID:
15308633
[PubMed - indexed for MEDLINE]
Free Article
14.

The biosynthesis of mycolic acids in Mycobacterium tuberculosis relies on multiple specialized elongation complexes interconnected by specific protein-protein interactions.

Veyron-Churlet R, Bigot S, Guerrini O, Verdoux S, Malaga W, Daffé M, Zerbib D.

J Mol Biol. 2005 Nov 4;353(4):847-58. Epub 2005 Sep 23.

PMID:
16213523
[PubMed - indexed for MEDLINE]
15.

Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis.

Takayama K, Wang C, Besra GS.

Clin Microbiol Rev. 2005 Jan;18(1):81-101. Review.

PMID:
15653820
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis.

Yuan Y, Lee RE, Besra GS, Belisle JT, Barry CE 3rd.

Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6630-4.

PMID:
7604045
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.

Huang CC, Smith CV, Glickman MS, Jacobs WR Jr, Sacchettini JC.

J Biol Chem. 2002 Mar 29;277(13):11559-69. Epub 2001 Dec 26.

PMID:
11756461
[PubMed - indexed for MEDLINE]
Free Article
18.

Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis.

Slayden RA, Lee RE, Armour JW, Cooper AM, Orme IM, Brennan PJ, Besra GS.

Antimicrob Agents Chemother. 1996 Dec;40(12):2813-9.

PMID:
9124847
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis.

Schroeder EK, de Souza N, Santos DS, Blanchard JS, Basso LA.

Curr Pharm Biotechnol. 2002 Sep;3(3):197-225. Review.

PMID:
12164478
[PubMed - indexed for MEDLINE]
20.

The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan.

Lea-Smith DJ, Pyke JS, Tull D, McConville MJ, Coppel RL, Crellin PK.

J Biol Chem. 2007 Apr 13;282(15):11000-8. Epub 2007 Feb 17.

PMID:
17308303
[PubMed - indexed for MEDLINE]
Free Article

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