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Results: 1 to 20 of 237

1.

Toward synthesis of the isosteric sulfonate analogues of the AT-III binding domain of heparin.

Herczeg M, Lázár L, Borbás A, Lipták A, Antus S.

Org Lett. 2009 Jun 18;11(12):2619-22. doi: 10.1021/ol900952d.

PMID:
19473011
[PubMed - indexed for MEDLINE]
2.

Synthesis of disaccharide fragments of the AT-III binding domain of heparin and their sulfonatomethyl analogues.

Herczeg M, Lázár L, Mándi A, Borbás A, Komáromi I, Lipták A, Antus S.

Carbohydr Res. 2011 Sep 27;346(13):1827-36. doi: 10.1016/j.carres.2011.06.021. Epub 2011 Jun 24.

PMID:
21798526
[PubMed - indexed for MEDLINE]
3.

Synthesis of a 3-deoxy-L-iduronic acid containing heparin pentasaccharide to probe the conformation of the antithrombin III binding sequence.

Lei PS, Duchaussoy P, Sizun P, Mallet JM, Petitou M, Sinaÿ P.

Bioorg Med Chem. 1998 Aug;6(8):1337-46.

PMID:
9784873
[PubMed - indexed for MEDLINE]
4.

Synthesis and anticoagulant activity of bioisosteric sulfonic-Acid analogues of the antithrombin-binding pentasaccharide domain of heparin.

Herczeg M, Lázár L, Bereczky Z, Kövér KE, Timári I, Kappelmayer J, Lipták A, Antus S, Borbás A.

Chemistry. 2012 Aug 20;18(34):10643-52. doi: 10.1002/chem.201201041. Epub 2012 Jul 10.

PMID:
22782535
[PubMed - indexed for MEDLINE]
5.

Synthesis of conformationally locked L-iduronic acid derivatives: direct evidence for a critical role of the skew-boat 2S0 conformer in the activation of antithrombin by heparin.

Das SK, Mallet JM, Esnault J, Driguez PA, Duchaussoy P, Sizun P, Herault JP, Herbert JM, Petitou M, Sinaÿ P.

Chemistry. 2001 Nov 19;7(22):4821-34.

PMID:
11763451
[PubMed - indexed for MEDLINE]
6.

Synthesis of new conformationally constrained pentasaccharides as molecular probes to investigate the biological activity of heparin.

Sisu E, Tripathy S, Mallet JM, Driguez PA, Hérault JP, Sizun P, Herbert JM, Petitou M, Sinay P.

Biochimie. 2003 Jan-Feb;85(1-2):91-9.

PMID:
12765779
[PubMed - indexed for MEDLINE]
7.

An efficient synthesis of L-idose and L-iduronic acid thioglycosides and their use for the synthesis of heparin oligosaccharides.

Tatai J, Osztrovszky G, Kajtár-Peredy M, Fügedi P.

Carbohydr Res. 2008 Mar 17;343(4):596-606. doi: 10.1016/j.carres.2007.12.015. Epub 2007 Dec 25.

PMID:
18237719
[PubMed - indexed for MEDLINE]
8.

Mono- and bidimensional 500 MHz 1H-NMR spectra of a synthetic pentasaccharide corresponding to the binding sequence of heparin to antithrombin-III: evidence for conformational peculiarity of the sulfated iduronate residue.

Torri G, Casu B, Gatti G, Petitou M, Choay J, Jacquinet JC, Sinaÿ P.

Biochem Biophys Res Commun. 1985 Apr 16;128(1):134-40.

PMID:
3985961
[PubMed - indexed for MEDLINE]
9.

1H NMR spectroscopic studies on the interactions between human plasma antithrombin III and defined low molecular weight heparin fragments.

Horne A, Gettins P.

Biochemistry. 1992 Mar 3;31(8):2286-94.

PMID:
1311598
[PubMed - indexed for MEDLINE]
10.

Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites.

Desai UR, Petitou M, Björk I, Olson ST.

Biochemistry. 1998 Sep 15;37(37):13033-41.

PMID:
9737884
[PubMed - indexed for MEDLINE]
11.

Conformation of the pentasaccharide corresponding to the binding site of heparin for antithrombin III.

Ragazzi M, Ferro DR, Perly B, Sinaÿ P, Petitou M, Choay J.

Carbohydr Res. 1990 Jan 15;195(2):169-85.

PMID:
2331700
[PubMed - indexed for MEDLINE]
12.

Conformational selection of the AGA*IA(M) heparin pentasaccharide when bound to the fibroblast growth factor receptor.

Nieto L, Canales Á, Giménez-Gallego G, Nieto PM, Jiménez-Barbero J.

Chemistry. 2011 Sep 26;17(40):11204-9. doi: 10.1002/chem.201101000. Epub 2011 Aug 25.

PMID:
21922554
[PubMed - indexed for MEDLINE]
13.

Conformation of heparin pentasaccharide bound to antithrombin III.

Hricovíni M, Guerrini M, Bisio A, Torri G, Petitou M, Casu B.

Biochem J. 2001 Oct 15;359(Pt 2):265-72.

PMID:
11583572
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

1H-N.m.r. spectral assignments for two series of heparin-derived oligosaccharides.

Horne A, Gettins P.

Carbohydr Res. 1992 Feb 17;225(1):43-57.

PMID:
1633604
[PubMed - indexed for MEDLINE]
15.

Sulfamate proton solvent exchange in heparin oligosaccharides: evidence for a persistent hydrogen bond in the antithrombin-binding pentasaccharide Arixtra.

Langeslay DJ, Young RP, Beni S, Beecher CN, Mueller LJ, Larive CK.

Glycobiology. 2012 Sep;22(9):1173-82. doi: 10.1093/glycob/cws085. Epub 2012 May 16.

PMID:
22593556
[PubMed - indexed for MEDLINE]
Free Article
16.

Synthesis of heparin partial structures and their binding activities to platelets.

Koshida S, Suda Y, Sobel M, Ormsby J, Kusumoto S.

Bioorg Med Chem Lett. 1999 Nov 1;9(21):3127-32.

PMID:
10560738
[PubMed - indexed for MEDLINE]
17.

Heparinase I acts on a synthetic heparin pentasaccharide corresponding to the antithrombin III binding site.

Yu G, LeBrun L, Gunay NS, Hoppensteadt D, Walenga JM, Fareed J, Linhardt RJ.

Thromb Res. 2000 Dec 15;100(6):549-56.

PMID:
11152935
[PubMed - indexed for MEDLINE]
18.

Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity.

Choay J, Petitou M, Lormeau JC, Sinaÿ P, Casu B, Gatti G.

Biochem Biophys Res Commun. 1983 Oct 31;116(2):492-9.

PMID:
6651824
[PubMed - indexed for MEDLINE]
19.

Synthesis and scalable conversion of L-iduronamides to heparin-related di- and tetrasaccharides.

Hansen SU, Miller GJ, Baráth M, Broberg KR, Avizienyte E, Helliwell M, Raftery J, Jayson GC, Gardiner JM.

J Org Chem. 2012 Sep 21;77(18):7823-43. Epub 2012 Sep 4.

PMID:
22900939
[PubMed - indexed for MEDLINE]
20.

A synthetic antithrombin III binding pentasaccharide is now a drug! What comes next?

Petitou M, van Boeckel CA.

Angew Chem Int Ed Engl. 2004 Jun 14;43(24):3118-33. Review.

PMID:
15199558
[PubMed - indexed for MEDLINE]

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