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19464103,17579866,17768706,18281615,19737590,20154064,16925576,18373709,22099584,16213582,18399173,15269157,17610208,19066127,14679005,17090671,19405528,10962573,19329756,17064348,17121904,28681940,22694478,23069143,18245548,14695217,17949452,22573351,22246317,21395580,22480737,26408708,15935620,19956882,16203796,27498942,19440933,20493187,16288046,23586877,16854066,22194440,22470109,16844778,22150087,18245550,15841378,19850405,17870069,19748980,18594209,19826195,16218955,26662567,17667592,12905631,15897590,18676850,16868182,17230513,18455150,19458065,20394503,17617451,17185503,17319785,19628238,19208749,23246572,16428328,18954528,18175003,15661225,23886587,17108135,17157164,17893518,19764559,17662999,26872308,17599753,14555522,14508491,17088896,18630678,18800240,16482209,19528462,21632108,19781773,26913406,19632215,24650873,19642950,18772114,16784024,20738310,18357975,19371599,20667592,23641970,17259553,16982765,18242184,18570972,23629654,15388159,21144839,17363505,21219297,16620576,26786409,16431970,17085670,17975158,19027068,22922826,19408974,33202406,19734938,25153785,18703780,14603521,19671844,19519743,25263741,29433909,16367912,19148492,16501598,17096299,16155577,27658586,22445681,22810956,15972449,17308081,17332306,22566192,22547655,19026643,16882944,17631308,16923571,15610846,18977205,22687408,17016641,25159299,16311509,18552505,19440035,17022645,16452239,20219895,28412732,27887849,16385472,29061812,27268613,27894402,25681003,16938294,18194434,19861537,18320580,19245816,16741950,24961936,17487411,20428829,16546966,17147113,17645779,20406843,20444924,27878398,18591380,18347186,17855662,17804463,18243703,18720425,16926059,15950770,19324279,25544127,18794130,28624441,25105924,18220746,19162015,23564374,17404111,16552710,17219417,29602128,21821695,29651431,20188076,21519787,25202074,15013520,28306192,18800759,28954352,18281495,16889231,20211249,26416354,23469976,25980180,18488507,17979263,25696978,16827149,21875325,22706881,15051534,32319637,18827603,16723087,26219569,19084447,20828379,26642940,23013759,33370472,20351313,18718841,20841485,21515049,16634649,27342489,17233845,16890800,19809428,22105779,27489107,24303801,24090817,19014912,15791458,22138446,33537004,18001136,19244114,21498475,19502802,18676857,21663398,16544941,24718854,23443787,28182573,20398291,25277067,20035426,20416086,31175180,16698020,20710066,20138989,22955701,17181154,18410996,17242689,16697713,16860662,18645008,20055425,28542269,19632771,32497199,23376257,22066472,24692538,17525741,19336574,18386162,20883729,19154416,18852129,18239673,34794206,20651072,25682284,19036086,17114345,17252137,28032595,23860250,17956728,33149557,19142186,27224288,25096912,27107422,31336120,19466875,25041838,28551637,18660379,31963524,18071306,30175776,26502919,19576865,20946630,30021337,30098331,27503106,22751135,19402537,25712415,25374192,26677324,27862436,29499568,20663926,17062684,17093460,19509067,25351442,27297424,23350198,25227799,19948165,14551138,17397803,17513464,21837531,17284253,25141341,15989551,24819277,17440091,25060629,28450396,24465691,24524692,18337455,23873112,17909811,15567157,19509149,24903735,15081540,25920748,25957766,28823258,20861078,29953987,23261432,19631775,26922527,27075590,17363512,31611575,24859453,25572106,30727894,30982499,17109011,21129190,33416122,21490339,17606706,28914785,18771179,17875604,33609515,22490666,19441108,31346611,21448187,18197612,19414312,19549529,24886060,18852131,22019372,19573523,34016843,25537129,19369241,18497978,21605975,19576519,21037799,19464431,26157347,19914055,32236591,26379118,17024233,26957545,19690146,26111331,24299925,22167270,18293999,17079230,23635099,28823260,14678981,32377704,32151689,24692709,19118027,22691173,16630568,16752309,25855731,19308924,25366476,20920318,23457505,11776586,18984579,21682254,25341914,18462865,19685544,21251717,17003370,17327415,21983172,24705874,28009484,18157579,26268232,18304811,18036348,24286867,17926180,20837488,28871086,16381049,26414348,27909289,30214897,25556684,17869098,17088927,23630365,31595984,24676905,18785742,19515997,31778773,33939678,16307487,19741006,24360559,21408192,18675372,28143869,19440708,28550532,19099249,24810052,20552022,24518700,17163760,19435295,30640172,17179467,19555670,23658841,35397061,18929486,33670684,20452380,19640711,31370342,17409432,28913790,19144404,31006970,19945858,18442885,19443225,19066230,19383903,16821709,19353939,16821127,19711354,22277058,22268041,23763277,15168026,21353544,19901558,22711259,18554719,19799869,28529458,20138026,19578756,15796919,27205876,18644253,18511277,28438108,21543763,25308700,22120110,19514085,19703066,29471895,19484761,19266313,28910138,18572099,26595743,24667540,26252737,22843495,32527461,16019471,19348876,19717982,17311328,19607815,19576239,19006077,18190862,34406420,22337586,21278242,16165354,29807855,28483634,23843639,17968312,26116697,19225933,32184171,33621432,18314631,24909268,12569668,26818344,33080246,23745360,31634779,20829357,23047954,29543923,28078663,17921448,20812146,22235098,32264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Year	Number of Results
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720 results

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Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via beta-catenin/TCF7L2 pathway in adult T cell leukemia cells.

Kurashina R, Ohyashiki JH, Kobayashi C, Hamamura R, Zhang Y, Hirano T, Ohyashiki K. Kurashina R, et al. Cancer Lett. 2009 Oct 18;284(1):62-70. doi: 10.1016/j.canlet.2009.04.012. Epub 2009 May 21. Cancer Lett. 2009. PMID: 19464103

Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.

Schwock J, Pham NA, Cao MP, Hedley DW. Schwock J, et al. Cancer Chemother Pharmacol. 2008 Apr;61(4):669-81. doi: 10.1007/s00280-007-0522-8. Epub 2007 Jun 20. Cancer Chemother Pharmacol. 2008. PMID: 17579866

The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.

Jeon YK, Park CH, Kim KY, Li YC, Kim J, Kim YA, Paik JH, Park BK, Kim CW, Kim YN. Jeon YK, et al. J Pathol. 2007 Oct;213(2):170-9. doi: 10.1002/path.2219. J Pathol. 2007. PMID: 17768706

17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.

Babchia N, Calipel A, Mouriaux F, Faussat AM, Mascarelli F. Babchia N, et al. Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2348-56. doi: 10.1167/iovs.07-1305. Epub 2008 Feb 15. Invest Ophthalmol Vis Sci. 2008. PMID: 18281615

Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells.

Yoshikawa N, Nemoto T, Satoh S, Maruta T, Yanagita T, Chosa E, Wada A. Yoshikawa N, et al. Neurochem Int. 2010 Jan;56(1):42-50. doi: 10.1016/j.neuint.2009.08.013. Epub 2009 Sep 6. Neurochem Int. 2010. PMID: 19737590

Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis.

Madrigal-Matute J, López-Franco O, Blanco-Colio LM, Muñoz-García B, Ramos-Mozo P, Ortega L, Egido J, Martín-Ventura JL. Madrigal-Matute J, et al. Cardiovasc Res. 2010 May 1;86(2):330-7. doi: 10.1093/cvr/cvq046. Epub 2010 Feb 12. Cardiovasc Res. 2010. PMID: 20154064

The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.

Georgakis GV, Li Y, Younes A. Georgakis GV, et al. Br J Haematol. 2006 Oct;135(1):68-71. doi: 10.1111/j.1365-2141.2006.06247.x. Epub 2006 Aug 22. Br J Haematol. 2006. PMID: 16925576 Free article.

Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling.

Al Shaer L, Walsby E, Gilkes A, Tonks A, Walsh V, Mills K, Burnett A, Rowntree C. Al Shaer L, et al. Br J Haematol. 2008 May;141(4):483-93. doi: 10.1111/j.1365-2141.2008.07053.x. Epub 2008 Mar 27. Br J Haematol. 2008. PMID: 18373709 Free article.

Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG.

Liu H, Zhang T, Chen R, McConkey DJ, Ward JF, Curley SA. Liu H, et al. J Surg Res. 2012 Jul;176(1):147-53. doi: 10.1016/j.jss.2011.09.017. Epub 2011 Oct 5. J Surg Res. 2012. PMID: 22099584

The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level.

Yu W, Rao Q, Wang M, Tian Z, Lin D, Liu X, Wang J. Yu W, et al. Leuk Res. 2006 May;30(5):575-82. doi: 10.1016/j.leukres.2005.08.028. Epub 2005 Oct 6. Leuk Res. 2006. PMID: 16213582

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