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Items: 1 to 20 of 565

1.

Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.

Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M.

PLoS One. 2009 May 20;4(5):e5622. doi: 10.1371/journal.pone.0005622.

2.

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.

Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H, Iwama A.

PLoS One. 2010 Aug 24;5(8):e12373. doi: 10.1371/journal.pone.0012373.

3.

Oncogenic activity of Cdc6 through repression of the INK4/ARF locus.

Gonzalez S, Klatt P, Delgado S, Conde E, Lopez-Rios F, Sanchez-Cespedes M, Mendez J, Antequera F, Serrano M.

Nature. 2006 Mar 30;440(7084):702-6.

PMID:
16572177
4.

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K.

Genes Dev. 2007 Mar 1;21(5):525-30.

5.
6.

Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.

Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2641-6. doi: 10.1073/pnas.0813139106. Epub 2009 Feb 6.

7.

SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus.

Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP.

Mol Cell Biol. 2008 May;28(10):3457-64. doi: 10.1128/MCB.02019-07. Epub 2008 Mar 10.

8.

Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.

Kranc KR, Bamforth SD, Bragança J, Norbury C, van Lohuizen M, Bhattacharya S.

Mol Cell Biol. 2003 Nov;23(21):7658-66.

9.

Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.

Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH.

EMBO J. 2007 Mar 21;26(6):1637-48. Epub 2007 Mar 1.

10.

Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression.

Aguilo F, Zhou MM, Walsh MJ.

Cancer Res. 2011 Aug 15;71(16):5365-9. doi: 10.1158/0008-5472.CAN-10-4379. Epub 2011 Aug 9. Review.

11.

Twist-1 induces Ezh2 recruitment regulating histone methylation along the Ink4A/Arf locus in mesenchymal stem cells.

Cakouros D, Isenmann S, Cooper L, Zannettino A, Anderson P, Glackin C, Gronthos S.

Mol Cell Biol. 2012 Apr;32(8):1433-41. doi: 10.1128/MCB.06315-11. Epub 2012 Jan 30.

12.

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, Kim SK.

Genes Dev. 2009 Apr 15;23(8):975-85. doi: 10.1101/gad.1742509.

13.

A new mechanism of inactivation of the INK4/ARF locus.

Gonzalez S, Serrano M.

Cell Cycle. 2006 Jul;5(13):1382-4. Epub 2006 Jul 1.

PMID:
16855387
14.

Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.

Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, Gil J, Walsh MJ, Zhou MM.

Mol Cell. 2010 Jun 11;38(5):662-74. doi: 10.1016/j.molcel.2010.03.021.

15.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.

Hepatology. 2010 Sep;52(3):1111-23. doi: 10.1002/hep.23793.

PMID:
20648475
16.

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.

Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, Van Lohuizen M, Band V, Campisi J, Dimri GP.

Mol Cell Biol. 2003 Jan;23(1):389-401.

17.

The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.

Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.

J Hepatol. 2010 Jun;52(6):854-63. doi: 10.1016/j.jhep.2010.01.027. Epub 2010 Mar 24.

PMID:
20395008
18.

Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.

Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD.

Sci Signal. 2012 Oct 23;5(247):ra77. doi: 10.1126/scisignal.2003199.

19.

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.

Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J.

Genes Dev. 2009 May 15;23(10):1177-82. doi: 10.1101/gad.511109.

20.

The Ink4/Arf locus is a barrier for iPS cell reprogramming.

Li H, Collado M, Villasante A, Strati K, Ortega S, Cañamero M, Blasco MA, Serrano M.

Nature. 2009 Aug 27;460(7259):1136-9. doi: 10.1038/nature08290. Epub 2009 Aug 9.

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