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Items: 1 to 20 of 100

2.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Wang Y, Zhao J, Jia S, Herich J, Labreque D, Storer R, Meerovitch K, Bouffard D, Rej R, Denis R, Blais C, Lamothe S, Attardo G, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2004 Dec 2;47(25):6299-310.

PMID:
15566300
3.

Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity.

Kasibhatla S, Gourdeau H, Meerovitch K, Drewe J, Reddy S, Qiu L, Zhang H, Bergeron F, Bouffard D, Yang Q, Herich J, Lamothe S, Cai SX, Tseng B.

Mol Cancer Ther. 2004 Nov;3(11):1365-74.

4.

Discovery of substituted N-phenyl nicotinamides as potent inducers of apoptosis using a cell- and caspase-based high throughput screening assay.

Cai SX, Nguyen B, Jia S, Herich J, Guastella J, Reddy S, Tseng B, Drewe J, Kasibhatla S.

J Med Chem. 2003 Jun 5;46(12):2474-81.

PMID:
12773051
5.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7,8-positions.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Zhao J, Crogan-Grundy C, Xu L, Lamothe S, Gourdeau H, Denis R, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2007 Jun 14;50(12):2858-64. Epub 2007 May 11.

PMID:
17497765
6.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Crogan-Grundy C, Labreque D, Bubenick M, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2008 Feb 14;51(3):417-23. doi: 10.1021/jm7010657. Epub 2008 Jan 16.

PMID:
18197614
7.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.

Kemnitzer W, Kasibhatla S, Jiang S, Zhang H, Zhao J, Jia S, Xu L, Crogan-Grundy C, Denis R, Barriault N, Vaillancourt L, Charron S, Dodd J, Attardo G, Labrecque D, Lamothe S, Gourdeau H, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4745-51.

PMID:
16143530
8.

Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.

Kemnitzer W, Jiang S, Zhang H, Kasibhatla S, Crogan-Grundy C, Blais C, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5571-5. doi: 10.1016/j.bmcl.2008.09.011. Epub 2008 Sep 6. Erratum in: Bioorg Med Chem Lett. 2009 Jan 15;19(2):554.

PMID:
18805007
10.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: modifications of the 2- and 3-positions.

Kemnitzer W, Jiang S, Wang Y, Kasibhatla S, Crogan-Grundy C, Bubenik M, Labrecque D, Denis R, Lamothe S, Attardo G, Gourdeau H, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):603-7. Epub 2007 Nov 28.

PMID:
18077161
11.

Anti-proliferative and apoptotic effects of the derivatives from 4-aryl-4H-chromene family on human leukemia K562 cells.

Aryapour H, Mahdavi M, Mohebbi SR, Zali MR, Foroumadi A.

Arch Pharm Res. 2012 Sep;35(9):1573-82. doi: 10.1007/s12272-012-0908-y. Epub 2012 Oct 9.

PMID:
23054714
12.

Antivascular and antitumor evaluation of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes, a novel series of anticancer agents.

Gourdeau H, Leblond L, Hamelin B, Desputeau C, Dong K, Kianicka I, Custeau D, Boudreau C, Geerts L, Cai SX, Drewe J, Labrecque D, Kasibhatla S, Tseng B.

Mol Cancer Ther. 2004 Nov;3(11):1375-84.

13.

Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers.

Kemnitzer W, Sirisoma N, May C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3536-40. doi: 10.1016/j.bmcl.2009.04.145. Epub 2009 May 5.

PMID:
19464890
14.

Synthesis and in-vitro cytotoxicity of poly-functionalized 4-(2-arylthiazol-4-yl)-4H-chromenes.

Mahmoodi M, Aliabadi A, Emami S, Safavi M, Rajabalian S, Mohagheghi MA, Khoshzaban A, Samzadeh-Kermani A, Lamei N, Shafiee A, Foroumadi A.

Arch Pharm (Weinheim). 2010 Jul;343(7):411-6. doi: 10.1002/ardp.200900198.

PMID:
20309872
15.

Concomitant activation of caspase-9 and down-regulation of IAP proteins as a mechanism of apoptotic death in HepG2, T47D and HCT-116 cells upon exposure to a derivative from 4-aryl-4H-chromenes family.

Mahdavi M, Davoodi J, Zali MR, Foroumadi A.

Biomed Pharmacother. 2011 Jun;65(3):175-82. doi: 10.1016/j.biopha.2011.03.001. Epub 2011 Apr 8.

PMID:
21565459
16.

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay.

Zhang HZ, Kasibhatla S, Wang Y, Herich J, Guastella J, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem. 2004 Jan 15;12(2):309-17.

PMID:
14723951
17.

Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay.

Jiang S, Crogan-Grundy C, Drewe J, Tseng B, Cai SX.

Bioorg Med Chem Lett. 2008 Nov 1;18(21):5725-8. doi: 10.1016/j.bmcl.2008.09.088. Epub 2008 Sep 27.

PMID:
18849165
18.

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.

Sirisoma N, Kasibhatla S, Nguyen B, Pervin A, Wang Y, Claassen G, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem. 2006 Dec 1;14(23):7761-73. Epub 2006 Aug 21.

PMID:
16919962
19.

Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay.

Sirisoma N, Pervin A, Drewe J, Tseng B, Cai SX.

Bioorg Med Chem Lett. 2009 May 15;19(10):2710-3. doi: 10.1016/j.bmcl.2009.03.121. Epub 2009 Mar 28.

PMID:
19369076
20.

MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.

Kasibhatla S, Baichwal V, Cai SX, Roth B, Skvortsova I, Skvortsov S, Lukas P, English NM, Sirisoma N, Drewe J, Pervin A, Tseng B, Carlson RO, Pleiman CM.

Cancer Res. 2007 Jun 15;67(12):5865-71.

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