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Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection.

Schuck SD, Mueller H, Kunitz F, Neher A, Hoffmann H, Franken KL, Repsilber D, Ottenhoff TH, Kaufmann SH, Jacobsen M.

PLoS One. 2009;4(5):e5590. doi: 10.1371/journal.pone.0005590. Epub 2009 May 18.


Higher frequency of T-cell response to M. tuberculosis latency antigen Rv2628 at the site of active tuberculosis disease than in peripheral blood.

Chiacchio T, Petruccioli E, Vanini V, Butera O, Cuzzi G, Petrone L, Matteucci G, Lauria FN, Franken KL, Girardi E, Ottenhoff TH, Goletti D.

PLoS One. 2011;6(11):e27539. doi: 10.1371/journal.pone.0027539. Epub 2011 Nov 10.


Different patterns of cytokines and chemokines combined with IFN-γ production reflect Mycobacterium tuberculosis infection and disease.

Yu Y, Zhang Y, Hu S, Jin D, Chen X, Jin Q, Liu H.

PLoS One. 2012;7(9):e44944. doi: 10.1371/journal.pone.0044944. Epub 2012 Sep 13.


Comparison of T-cell interferon-gamma release assays for Mycobacterium tuberculosis-specific antigens in patients with active and latent tuberculosis.

Kobashi Y, Shimizu H, Ohue Y, Mouri K, Obase Y, Miyashita N, Oka M.

Lung. 2010 Aug;188(4):283-7. doi: 10.1007/s00408-010-9238-3. Epub 2010 Apr 27.


[Evolution of IGRA researches].

Ariga H, Harada N.

Kekkaku. 2008 Sep;83(9):641-52. Review. Japanese.


Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease.

Govender L, Abel B, Hughes EJ, Scriba TJ, Kagina BM, de Kock M, Walzl G, Black G, Rosenkrands I, Hussey GD, Mahomed H, Andersen P, Hanekom WA.

Vaccine. 2010 Dec 10;29(1):51-7. doi: 10.1016/j.vaccine.2010.10.022. Epub 2010 Oct 23.


T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals.

Martinez V, Carcelain G, Badell E, Jouan M, Mauger I, Sellier P, Truffot C, Bricaire F, Arend SM, Ottenhoff T, Autran B, Gicquel B.

BMC Infect Dis. 2007 Jul 26;7:83.


Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in Japan.

Hozumi H, Tsujimura K, Yamamura Y, Seto S, Uchijima M, Nagata T, Miwa S, Hayakawa H, Fujisawa T, Hashimoto D, Inui N, Suda T, Chida K, Koide Y.

Int J Tuberc Lung Dis. 2013 Jun;17(6):818-24. doi: 10.5588/ijtld.12.0695.


Identification of early secretory antigen target-6 epitopes for the immunodiagnosis of active tuberculosis.

Vincenti D, Carrara S, De Mori P, Pucillo LP, Petrosillo N, Palmieri F, Armignacco O, Ippolito G, Girardi E, Amicosante M, Goletti D.

Mol Med. 2003 Mar-Apr;9(3-4):105-11.


Humoral response to HspX and GlcB to previous and recent infection by Mycobacterium tuberculosis.

Rabahi MF, Junqueira-Kipnis AP, Dos Reis MC, Oelemann W, Conde MB.

BMC Infect Dis. 2007 Dec 31;7:148. doi: 10.1186/1471-2334-7-148.


Frequencies of region of difference 1 antigen-specific but not purified protein derivative-specific gamma interferon-secreting T cells correlate with the presence of tuberculosis disease but do not distinguish recent from remote latent infections.

Hinks TS, Dosanjh DP, Innes JA, Pasvol G, Hackforth S, Varia H, Millington KA, Liu XQ, Bakir M, Soysal A, Davidson RN, Gunatheesan R, Lalvani A.

Infect Immun. 2009 Dec;77(12):5486-95. doi: 10.1128/IAI.01436-08. Epub 2009 Sep 14.


T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia.

Riaño F, Arroyo L, París S, Rojas M, Friggen AH, van Meijgaarden KE, Franken KL, Ottenhoff TH, García LF, Barrera LF.

Tuberculosis (Edinb). 2012 Mar;92(2):148-59. doi: 10.1016/ Epub 2012 Jan 5.


Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells.

Chapman AL, Munkanta M, Wilkinson KA, Pathan AA, Ewer K, Ayles H, Reece WH, Mwinga A, Godfrey-Faussett P, Lalvani A.

AIDS. 2002 Nov 22;16(17):2285-93.


Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.

Leyten EM, Lin MY, Franken KL, Friggen AH, Prins C, van Meijgaarden KE, Voskuil MI, Weldingh K, Andersen P, Schoolnik GK, Arend SM, Ottenhoff TH, Klein MR.

Microbes Infect. 2006 Jul;8(8):2052-60. Epub 2006 Jun 13.


Quantitative evaluation of T-cell response after specific antigen stimulation in active and latent tuberculosis infection in adults and children.

Latorre I, De Souza-Galvão M, Ruiz-Manzano J, Lacoma A, Prat C, Fuenzalida L, Altet N, Ausina V, Domínguez J.

Diagn Microbiol Infect Dis. 2009 Nov;65(3):236-46. doi: 10.1016/j.diagmicrobio.2009.07.015.


Mycobacterium tuberculosis-specific CD4+, IFNgamma+, and TNFalpha+ multifunctional memory T cells coexpress GM-CSF.

Mueller H, Detjen AK, Schuck SD, Gutschmidt A, Wahn U, Magdorf K, Kaufmann SH, Jacobsen M.

Cytokine. 2008 Aug;43(2):143-8. doi: 10.1016/j.cyto.2008.05.002. Epub 2008 Jul 7.


Rv1985c, a promising novel antigen for diagnosis of tuberculosis infection from BCG-vaccinated controls.

Chen J, Wang S, Zhang Y, Su X, Wu J, Shao L, Wang F, Zhang S, Weng X, Wang H, Zhang W.

BMC Infect Dis. 2010 Sep 17;10:273. doi: 10.1186/1471-2334-10-273.


Double- and monofunctional CD4⁺ and CD8⁺ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals.

Commandeur S, Lin MY, van Meijgaarden KE, Friggen AH, Franken KL, Drijfhout JW, Korsvold GE, Oftung F, Geluk A, Ottenhoff TH.

Eur J Immunol. 2011 Oct;41(10):2925-36. doi: 10.1002/eji.201141602. Epub 2011 Aug 30.


Latent tuberculosis infection treatment and T-cell responses to Mycobacterium tuberculosis-specific antigens.

Chee CB, KhinMar KW, Gan SH, Barkham TM, Pushparani M, Wang YT.

Am J Respir Crit Care Med. 2007 Feb 1;175(3):282-7. Epub 2006 Nov 2.

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