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Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity.

Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL.

FASEB J. 2009 Sep;23(9):3226-32. doi: 10.1096/fj.09-132019. Epub 2009 May 11.


Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β.

Punia S, Rumery KK, Yu EA, Lambert CM, Notkins AL, Weaver DR.

Am J Physiol Endocrinol Metab. 2012 Sep 15;303(6):E762-76. doi: 10.1152/ajpendo.00513.2011. Epub 2012 Jul 11.


Disturbances in the secretion of neurotransmitters in IA-2/IA-2beta null mice: changes in behavior, learning and lifespan.

Nishimura T, Kubosaki A, Ito Y, Notkins AL.

Neuroscience. 2009 Mar 17;159(2):427-37. doi: 10.1016/j.neuroscience.2009.01.022.


Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway.

Kim SM, Theilig F, Qin Y, Cai T, Mizel D, Faulhaber-Walter R, Hirai H, Bachmann S, Briggs JP, Notkins AL, Schnermann J.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F382-9. doi: 10.1152/ajprenal.90543.2008. Epub 2008 Nov 19.


Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles.

Cai T, Hirai H, Zhang G, Zhang M, Takahashi N, Kasai H, Satin LS, Leapman RD, Notkins AL.

Diabetologia. 2011 Sep;54(9):2347-57. doi: 10.1007/s00125-011-2221-6. Epub 2011 Jul 6.


Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility.

Kubosaki A, Nakamura S, Clark A, Morris JF, Notkins AL.

Endocrinology. 2006 Feb;147(2):811-5. Epub 2005 Nov 3.


Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta.

Henquin JC, Nenquin M, Szollosi A, Kubosaki A, Notkins AL.

J Endocrinol. 2008 Mar;196(3):573-81. doi: 10.1677/JOE-07-0496.


Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice.

Kubosaki A, Nakamura S, Notkins AL.

Diabetes. 2005 Dec;54 Suppl 2:S46-51.


The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning.

Carmona GN, Nishimura T, Schindler CW, Panlilio LV, Notkins AL.

Neuroscience. 2014 Jun 6;269:35-42. doi: 10.1016/j.neuroscience.2014.03.023. Epub 2014 Mar 21.


Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.

Kubosaki A, Gross S, Miura J, Saeki K, Zhu M, Nakamura S, Hendriks W, Notkins AL.

Diabetes. 2004 Jul;53(7):1684-91.


The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.

Harashima S, Clark A, Christie MR, Notkins AL.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9. Epub 2005 Jun 6.


Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.

Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS.

Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2307-11.


The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.

Cai T, Krause MW, Odenwald WF, Toyama R, Notkins AL.

Diabetologia. 2001 Jan;44(1):81-8.


The IA-2 interactome.

Hu YF, Zhang HL, Cai T, Harashima S, Notkins AL.

Diabetologia. 2005 Dec;48(12):2576-81. Epub 2005 Nov 5.


A TTX-sensitive local circuit is involved in the expression of PK2 and BDNF circadian rhythms in the mouse suprachiasmatic nucleus.

Baba K, Ono D, Honma S, Honma K.

Eur J Neurosci. 2008 Feb;27(4):909-16. doi: 10.1111/j.1460-9568.2008.06053.x. Epub 2008 Feb 13.


IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion.

Doi A, Shono T, Nishi M, Furuta H, Sasaki H, Nanjo K.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):885-90. Epub 2006 Jan 17.

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