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Items: 1 to 20 of 181

1.

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.

Palsson-McDermott EM, Doyle SL, McGettrick AF, Hardy M, Husebye H, Banahan K, Gong M, Golenbock D, Espevik T, O'Neill LA.

Nat Immunol. 2009 Jun;10(6):579-86. doi: 10.1038/ni.1727. Epub 2009 May 3.

PMID:
19412184
2.

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.

Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF.

Nat Commun. 2012 Feb 28;3:707. doi: 10.1038/ncomms1706.

PMID:
22426228
3.

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

Carty M, Goodbody R, Schröder M, Stack J, Moynagh PN, Bowie AG.

Nat Immunol. 2006 Oct;7(10):1074-81. Epub 2006 Sep 10.

PMID:
16964262
4.

Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4.

Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X.

Blood. 2007 Aug 1;110(3):962-71. Epub 2007 Mar 29.

5.

Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

Naiki Y, Michelsen KS, Zhang W, Chen S, Doherty TM, Arditi M.

J Biol Chem. 2005 Feb 18;280(7):5491-5. Epub 2004 Dec 28.

6.

Inhibition of homodimerization of Toll-like receptor 4 by curcumin.

Youn HS, Saitoh SI, Miyake K, Hwang DH.

Biochem Pharmacol. 2006 Jun 28;72(1):62-9. Epub 2006 Apr 1.

PMID:
16678799
8.

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT.

J Exp Med. 2003 Oct 6;198(7):1043-55. Epub 2003 Sep 29. Erratum in: J Exp Med. 2003 Nov 3;198(9):following 1450.

9.

A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.

Nilsen NJ, Vladimer GI, Stenvik J, Orning MP, Zeid-Kilani MV, Bugge M, Bergstroem B, Conlon J, Husebye H, Hise AG, Fitzgerald KA, Espevik T, Lien E.

J Biol Chem. 2015 Feb 6;290(6):3209-22. doi: 10.1074/jbc.M114.593426. Epub 2014 Dec 11.

PMID:
25505250
10.

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.

Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, Miyake K.

Biochem Biophys Res Commun. 2008 Mar 28;368(1):94-9. doi: 10.1016/j.bbrc.2008.01.061. Epub 2008 Jan 28.

PMID:
18222170
11.
12.

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain.

Kawamoto T, Ii M, Kitazaki T, Iizawa Y, Kimura H.

Eur J Pharmacol. 2008 Apr 14;584(1):40-8. doi: 10.1016/j.ejphar.2008.01.026. Epub 2008 Feb 5.

PMID:
18299127
13.

Differential induction of MyD88- and TRIF-dependent pathways in equine monocytes by Toll-like receptor agonists.

Figueiredo MD, Vandenplas ML, Hurley DJ, Moore JN.

Vet Immunol Immunopathol. 2009 Jan 15;127(1-2):125-34. doi: 10.1016/j.vetimm.2008.09.028. Epub 2008 Oct 11.

PMID:
19019456
14.

Signaling flux redistribution at toll-like receptor pathway junctions.

Selvarajoo K, Takada Y, Gohda J, Helmy M, Akira S, Tomita M, Tsuchiya M, Inoue J, Matsuo K.

PLoS One. 2008;3(10):e3430. doi: 10.1371/journal.pone.0003430. Epub 2008 Oct 17.

15.

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.

Schoenemeyer A, Barnes BJ, Mancl ME, Latz E, Goutagny N, Pitha PM, Fitzgerald KA, Golenbock DT.

J Biol Chem. 2005 Apr 29;280(17):17005-12. Epub 2005 Jan 28.

16.

Small interfering RNA-directed targeting of Toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity.

Hua D, Liu MY, Cheng ZD, Qin XJ, Zhang HM, Chen Y, Qin GJ, Liang G, Li JN, Han XF, Liu DX.

Mol Immunol. 2009 Sep;46(15):2876-84. doi: 10.1016/j.molimm.2009.06.016. Epub 2009 Jul 29.

PMID:
19643479
17.

Acrolein with an alpha, beta-unsaturated carbonyl group inhibits LPS-induced homodimerization of toll-like receptor 4.

Lee JS, Lee JY, Lee MY, Hwang DH, Youn HS.

Mol Cells. 2008 Apr 30;25(2):253-7. Epub 2008 Mar 31.

19.

TRAM is required for TLR2 endosomal signaling to type I IFN induction.

Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG.

J Immunol. 2014 Dec 15;193(12):6090-102. doi: 10.4049/jimmunol.1401605. Epub 2014 Nov 10.

20.

Inhibition of clathrin/dynamin-dependent internalization interferes with LPS-mediated TRAM-TRIF-dependent signaling pathway.

Wang Y, Yang Y, Liu X, Wang N, Cao H, Lu Y, Zhou H, Zheng J.

Cell Immunol. 2012;274(1-2):121-9. doi: 10.1016/j.cellimm.2011.12.007. Epub 2012 Jan 2.

PMID:
22341560
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