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Results: 1 to 20 of 310

1.

Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group.

Kemnitzer W, Sirisoma N, Nguyen B, Jiang S, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):3045-9. doi: 10.1016/j.bmcl.2009.04.009. Epub 2009 Apr 8.

PMID:
19394823
[PubMed - indexed for MEDLINE]
2.

Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 9-oxo-9H-fluorene ring.

Kemnitzer W, Sirisoma N, Jiang S, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1288-92. doi: 10.1016/j.bmcl.2009.11.025. Epub 2009 Nov 12.

PMID:
20034792
[PubMed - indexed for MEDLINE]
3.

Discovery of substituted N-phenyl nicotinamides as potent inducers of apoptosis using a cell- and caspase-based high throughput screening assay.

Cai SX, Nguyen B, Jia S, Herich J, Guastella J, Reddy S, Tseng B, Drewe J, Kasibhatla S.

J Med Chem. 2003 Jun 5;46(12):2474-81.

PMID:
12773051
[PubMed - indexed for MEDLINE]
4.

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions.

Kemnitzer W, Kuemmerle J, Jiang S, Zhang HZ, Sirisoma N, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6259-64. doi: 10.1016/j.bmcl.2008.09.110. Epub 2008 Oct 17.

PMID:
18952423
[PubMed - indexed for MEDLINE]
5.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Wang Y, Zhao J, Jia S, Herich J, Labreque D, Storer R, Meerovitch K, Bouffard D, Rej R, Denis R, Blais C, Lamothe S, Attardo G, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2004 Dec 2;47(25):6299-310.

PMID:
15566300
[PubMed - indexed for MEDLINE]
6.

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure-activity relationships of the 4-, 5-, 6-, 7- and 8-positions.

Kemnitzer W, Kuemmerle J, Jiang S, Sirisoma N, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3481-4. doi: 10.1016/j.bmcl.2009.05.012. Epub 2009 May 8.

PMID:
19467598
[PubMed - indexed for MEDLINE]
7.

Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay.

Sirisoma N, Pervin A, Drewe J, Tseng B, Cai SX.

Bioorg Med Chem Lett. 2009 May 15;19(10):2710-3. doi: 10.1016/j.bmcl.2009.03.121. Epub 2009 Mar 28.

PMID:
19369076
[PubMed - indexed for MEDLINE]
8.

Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay.

Drewe J, Kasibhatla S, Tseng B, Shelton E, Sperandio D, Yee RM, Litvak J, Sendzik M, Spencer JR, Cai SX.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4987-90. Epub 2007 Jun 6.

PMID:
17562361
[PubMed - indexed for MEDLINE]
9.

Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay.

Jiang S, Crogan-Grundy C, Drewe J, Tseng B, Cai SX.

Bioorg Med Chem Lett. 2008 Nov 1;18(21):5725-8. doi: 10.1016/j.bmcl.2008.09.088. Epub 2008 Sep 27.

PMID:
18849165
[PubMed - indexed for MEDLINE]
10.

Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.

Kemnitzer W, Jiang S, Zhang H, Kasibhatla S, Crogan-Grundy C, Blais C, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5571-5. doi: 10.1016/j.bmcl.2008.09.011. Epub 2008 Sep 6. Erratum in: Bioorg Med Chem Lett. 2009 Jan 15;19(2):554.

PMID:
18805007
[PubMed - indexed for MEDLINE]
11.

Discovery of substituted 4-anilino-2-arylpyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 2. Structure-activity relationships of the 2-aryl group.

Sirisoma N, Pervin A, Nguyen B, Crogan-Grundy C, Kasibhatla S, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2305-9. doi: 10.1016/j.bmcl.2009.02.074. Epub 2009 Feb 23.

PMID:
19285392
[PubMed - indexed for MEDLINE]
12.

Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents.

Zhang HZ, Kasibhatla S, Kuemmerle J, Kemnitzer W, Ollis-Mason K, Qiu L, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

J Med Chem. 2005 Aug 11;48(16):5215-23.

PMID:
16078840
[PubMed - indexed for MEDLINE]
13.

Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers.

Kemnitzer W, Sirisoma N, May C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3536-40. doi: 10.1016/j.bmcl.2009.04.145. Epub 2009 May 5.

PMID:
19464890
[PubMed - indexed for MEDLINE]
14.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Crogan-Grundy C, Labreque D, Bubenick M, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2008 Feb 14;51(3):417-23. doi: 10.1021/jm7010657. Epub 2008 Jan 16.

PMID:
18197614
[PubMed - indexed for MEDLINE]
15.

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.

Sirisoma N, Kasibhatla S, Nguyen B, Pervin A, Wang Y, Claassen G, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem. 2006 Dec 1;14(23):7761-73. Epub 2006 Aug 21.

PMID:
16919962
[PubMed - indexed for MEDLINE]
16.

Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers.

Zhang HZ, Crogan-Grundy C, May C, Drewe J, Tseng B, Cai SX.

Bioorg Med Chem. 2009 Apr 1;17(7):2852-8. doi: 10.1016/j.bmc.2009.02.029. Epub 2009 Feb 21.

PMID:
19282188
[PubMed - indexed for MEDLINE]
17.

Discovery and structure-activity relationship of N-phenyl-1H-pyrazolo[3,4-b]quinolin-4-amines as a new series of potent apoptosis inducers.

Zhang HZ, Claassen G, Crogran-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem. 2008 Jan 1;16(1):222-31. Epub 2007 Oct 4.

PMID:
17950608
[PubMed - indexed for MEDLINE]
18.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7,8-positions.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Zhao J, Crogan-Grundy C, Xu L, Lamothe S, Gourdeau H, Denis R, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2007 Jun 14;50(12):2858-64. Epub 2007 May 11.

PMID:
17497765
[PubMed - indexed for MEDLINE]
19.

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay.

Zhang HZ, Kasibhatla S, Wang Y, Herich J, Guastella J, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem. 2004 Jan 15;12(2):309-17.

PMID:
14723951
[PubMed - indexed for MEDLINE]
20.

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