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Results: 1 to 20 of 101

1.

Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.

Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J.

Sci Signal. 2009 Apr 14;2(66):pt2. doi: 10.1126/scisignal.266pt2.

PMID:
19366993
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP.

Cell. 2009 Jan 23;136(2):337-51. doi: 10.1016/j.cell.2008.11.051.

PMID:
19167334
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.

Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A.

Mol Cell Biol. 2007 Apr;27(7):2732-45. Epub 2007 Feb 5.

PMID:
17283063
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Regulation of ras signaling dynamics by Sos-mediated positive feedback.

Boykevisch S, Zhao C, Sondermann H, Philippidou P, Halegoua S, Kuriyan J, Bar-Sagi D.

Curr Biol. 2006 Nov 7;16(21):2173-9.

PMID:
17084704
[PubMed - indexed for MEDLINE]
Free Article
5.

Loop domain peptides from the SOS ras-guanine nucleotide exchange protein, identified from molecular dynamics calculations, strongly inhibit ras signaling.

Chie L, Friedman FK, Duncan T, Chen JM, Chung D, Pincus M.

Protein J. 2004 Apr;23(3):229-34.

PMID:
15200054
[PubMed - indexed for MEDLINE]
6.

Structural analysis of autoinhibition in the Ras activator Son of sevenless.

Sondermann H, Soisson SM, Boykevisch S, Yang SS, Bar-Sagi D, Kuriyan J.

Cell. 2004 Oct 29;119(3):393-405.

PMID:
15507210
[PubMed - indexed for MEDLINE]
Free Article
7.

Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1.

Freedman TS, Sondermann H, Kuchment O, Friedland GD, Kortemme T, Kuriyan J.

Structure. 2009 Jan 14;17(1):41-53. doi: 10.1016/j.str.2008.11.004.

PMID:
19141281
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Signal transduction in T lymphocytes using a conditional allele of Sos.

Holsinger LJ, Spencer DM, Austin DJ, Schreiber SL, Crabtree GR.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9810-4.

PMID:
7568223
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.

Sperka T, Geissler KJ, Merkel U, Scholl I, Rubio I, Herrlich P, Morrison HL.

PLoS One. 2011;6(11):e27511. doi: 10.1371/journal.pone.0027511. Epub 2011 Nov 21.

PMID:
22132106
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.

Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J.

Cell. 2003 Mar 7;112(5):685-95.

PMID:
12628188
[PubMed - indexed for MEDLINE]
Free Article
11.

ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells.

Salojin KV, Zhang J, Meagher C, Delovitch TL.

J Biol Chem. 2000 Feb 25;275(8):5966-75.

PMID:
10681590
[PubMed - indexed for MEDLINE]
Free Article
12.

Regulation of Son of sevenless by the membrane-actin linker protein ezrin.

Gei├čler KJ, Jung MJ, Riecken LB, Sperka T, Cui Y, Schacke S, Merkel U, Markwart R, Rubio I, Than ME, Breithaupt C, Peuker S, Seifert R, Kaupp UB, Herrlich P, Morrison H.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20587-92. doi: 10.1073/pnas.1222078110. Epub 2013 Dec 2.

PMID:
24297905
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Membrane-dependent signal integration by the Ras activator Son of sevenless.

Gureasko J, Galush WJ, Boykevisch S, Sondermann H, Bar-Sagi D, Groves JT, Kuriyan J.

Nat Struct Mol Biol. 2008 May;15(5):452-61. doi: 10.1038/nsmb.1418. Epub 2008 May 4. Erratum in: Nat Struct Mol Biol.2008 Jun;15(6): 651.

PMID:
18454158
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Sos1 regulates sustained TCR-mediated Erk activation.

Poltorak M, Meinert I, Stone JC, Schraven B, Simeoni L.

Eur J Immunol. 2014 May;44(5):1535-40. doi: 10.1002/eji.201344046. Epub 2014 Feb 20.

PMID:
24497027
[PubMed - indexed for MEDLINE]
15.

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

Nimnual AS, Yatsula BA, Bar-Sagi D.

Science. 1998 Jan 23;279(5350):560-3.

PMID:
9438849
[PubMed - indexed for MEDLINE]
Free Article
16.

T cell receptor-induced phosphorylation of Sos requires activity of CD45, Lck, and protein kinase C, but not ERK.

Zhao H, Li YY, Fucini RV, Ross SE, Pessin JE, Koretzky GA.

J Biol Chem. 1997 Aug 22;272(34):21625-34.

PMID:
9261185
[PubMed - indexed for MEDLINE]
Free Article
17.

An orthosteric inhibitor of the RAS-SOS interaction.

Nickerson S, Joy ST, Arora PS, Bar-Sagi D.

Enzymes. 2013;34 Pt. B:25-39. doi: 10.1016/B978-0-12-420146-0.00002-0. Epub 2013 Nov 7. Review.

PMID:
25034099
[PubMed - indexed for MEDLINE]
18.

Deconstructing Ras signaling in the thymus.

Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.

Mol Cell Biol. 2012 Jul;32(14):2748-59. doi: 10.1128/MCB.00317-12. Epub 2012 May 14.

PMID:
22586275
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.

Reynolds LF, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz VL.

J Biol Chem. 2004 Apr 30;279(18):18239-46. Epub 2004 Feb 5.

PMID:
14764585
[PubMed - indexed for MEDLINE]
Free Article
20.

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

Innocenti M, Tenca P, Frittoli E, Faretta M, Tocchetti A, Di Fiore PP, Scita G.

J Cell Biol. 2002 Jan 7;156(1):125-36. Epub 2002 Jan 3.

PMID:
11777939
[PubMed - indexed for MEDLINE]
Free PMC Article

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