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Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor β/δ (PPARβ/δ).

Yu S, Levi L, Siegel R, Noy N.

J Biol Chem. 2012 Dec 7;287(50):42195-205. doi: 10.1074/jbc.M112.410381. Epub 2012 Oct 26.


Retinoic acid activation of peroxisome proliferation-activated receptor delta represses obesity and insulin resistance.

Wolf G.

Nutr Rev. 2010 Jan;68(1):67-70. doi: 10.1111/j.1753-4887.2009.00261.x. Review.


Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARbeta/delta to RAR.

Schug TT, Berry DC, Toshkov IA, Cheng L, Nikitin AY, Noy N.

Proc Natl Acad Sci U S A. 2008 May 27;105(21):7546-51. doi: 10.1073/pnas.0709981105. Epub 2008 May 21.


Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes.

Borland MG, Khozoie C, Albrecht PP, Zhu B, Lee C, Lahoti TS, Gonzalez FJ, Peters JM.

Cell Signal. 2011 Dec;23(12):2039-50. doi: 10.1016/j.cellsig.2011.07.020. Epub 2011 Aug 4.


Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesity.

Berry DC, DeSantis D, Soltanian H, Croniger CM, Noy N.

Diabetes. 2012 May;61(5):1112-21. doi: 10.2337/db11-1620. Epub 2012 Mar 6.


Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.

Rodríguez-Calvo R, Serrano L, Coll T, Moullan N, Sánchez RM, Merlos M, Palomer X, Laguna JC, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetes. 2008 Aug;57(8):2149-57. doi: 10.2337/db08-0176. Epub 2008 Apr 28.


Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells.

Thulasiraman P, McAndrews DJ, Mohiudddin IQ.

BMC Cancer. 2014 Sep 27;14:724. doi: 10.1186/1471-2407-14-724.


Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes.

Murholm M, Isidor MS, Basse AL, Winther S, Sørensen C, Skovgaard-Petersen J, Nielsen MM, Hansen AS, Quistorff B, Hansen JB.

BMC Cell Biol. 2013 Sep 23;14:41. doi: 10.1186/1471-2121-14-41.


Ligand-mediated regulation of peroxisome proliferator-activated receptor (PPAR) beta/delta: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid.

Rieck M, Meissner W, Ries S, Müller-Brüsselbach S, Müller R.

Mol Pharmacol. 2008 Nov;74(5):1269-77. doi: 10.1124/mol.108.050625. Epub 2008 Aug 13.


A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.

Schupp M, Curtin JC, Kim RJ, Billin AN, Lazar MA.

Mol Pharmacol. 2007 May;71(5):1251-7. Epub 2007 Feb 8.


Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes.

Serrano-Marco L, Rodríguez-Calvo R, El Kochairi I, Palomer X, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetes. 2011 Jul;60(7):1990-9. doi: 10.2337/db10-0704. Epub 2011 May 26.


PPARbeta/delta potentiates PPARgamma-stimulated adipocyte differentiation.

Matsusue K, Peters JM, Gonzalez FJ.

FASEB J. 2004 Sep;18(12):1477-9. Epub 2004 Jul 9.


Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes.

Borland MG, Foreman JE, Girroir EE, Zolfaghari R, Sharma AK, Amin S, Gonzalez FJ, Ross AC, Peters JM.

Mol Pharmacol. 2008 Nov;74(5):1429-42. doi: 10.1124/mol.108.050609. Epub 2008 Aug 7.


Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases.

Bedu E, Wahli W, Desvergne B.

Expert Opin Ther Targets. 2005 Aug;9(4):861-73. Review.


TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes.

Serrano-Marco L, Chacón MR, Maymó-Masip E, Barroso E, Salvadó L, Wabitsch M, Garrido-Sánchez L, Tinahones FJ, Palomer X, Vendrell J, Vázquez-Carrera M.

Biochim Biophys Acta. 2012 Sep;1821(9):1177-85. doi: 10.1016/j.bbalip.2012.05.006. Epub 2012 Jun 7.

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