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Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes.

Rathinam VA, Appledorn DM, Hoag KA, Amalfitano A, Mansfield LS.

Infect Immun. 2009 Jun;77(6):2499-507. doi: 10.1128/IAI.01562-08. Epub 2009 Mar 30.


Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation.

Shen H, Tesar BM, Walker WE, Goldstein DR.

J Immunol. 2008 Aug 1;181(3):1849-58.


Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.

Hise AG, Daehnel K, Gillette-Ferguson I, Cho E, McGarry HF, Taylor MJ, Golenbock DT, Fitzgerald KA, Kazura JW, Pearlman E.

J Immunol. 2007 Jan 15;178(2):1068-76.


TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo.

De Trez C, Pajak B, Brait M, Glaichenhaus N, Urbain J, Moser M, Lauvau G, Muraille E.

J Immunol. 2005 Jul 15;175(2):839-46.


Identification of a TLR4- and TRIF-dependent activation program of dendritic cells.

Weighardt H, Jusek G, Mages J, Lang R, Hoebe K, Beutler B, Holzmann B.

Eur J Immunol. 2004 Feb;34(2):558-64.


Critical role of TRIF and MyD88 in Mycobacterium tuberculosis Hsp70-mediated activation of dendritic cells.

Kim TH, Shin SJ, Park YM, Jung ID, Ryu SW, Kim DJ, Park JH, Park JH.

Cytokine. 2015 Feb;71(2):139-44. doi: 10.1016/j.cyto.2014.09.010. Epub 2014 Oct 29.


The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis.

Popovic ZV, Wang S, Papatriantafyllou M, Kaya Z, Porubsky S, Meisner M, Bonrouhi M, Burgdorf S, Young MF, Schaefer L, Gröne HJ.

J Immunol. 2011 Dec 15;187(12):6217-26. doi: 10.4049/jimmunol.1003478. Epub 2011 Nov 16.


Dual regulation of osteopontin production by TLR stimulation in dendritic cells.

Salvi V, Scutera S, Rossi S, Zucca M, Alessandria M, Greco D, Bosisio D, Sozzani S, Musso T.

J Leukoc Biol. 2013 Jul;94(1):147-58. doi: 10.1189/jlb.0412194. Epub 2013 Apr 22.


Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.

Piao W, Song C, Chen H, Diaz MA, Wahl LM, Fitzgerald KA, Li L, Medvedev AE.

J Leukoc Biol. 2009 Oct;86(4):863-75. doi: 10.1189/jlb.0309189. Epub 2009 Aug 5.


Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage.

Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, Wang JZ, Su BY, Yang QW.

J Neuroinflammation. 2012 Mar 6;9:46. doi: 10.1186/1742-2094-9-46.


Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient mice.

Oliveira AC, de Alencar BC, Tzelepis F, Klezewsky W, da Silva RN, Neves FS, Cavalcanti GS, Boscardin S, Nunes MP, Santiago MF, Nóbrega A, Rodrigues MM, Bellio M.

PLoS Pathog. 2010 Apr 29;6(4):e1000870. doi: 10.1371/journal.ppat.1000870.


TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways.

Sun Y, Karmakar M, Roy S, Ramadan RT, Williams SR, Howell S, Shive CL, Han Y, Stopford CM, Rietsch A, Pearlman E.

J Immunol. 2010 Oct 1;185(7):4272-83. doi: 10.4049/jimmunol.1000874. Epub 2010 Sep 8.


Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages.

Ruckdeschel K, Pfaffinger G, Haase R, Sing A, Weighardt H, Häcker G, Holzmann B, Heesemann J.

J Immunol. 2004 Sep 1;173(5):3320-8.


TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.

Siednienko J, Halle A, Nagpal K, Golenbock DT, Miggin SM.

Eur J Immunol. 2010 Nov;40(11):3150-60. doi: 10.1002/eji.201040547. Epub 2010 Oct 19.


The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.

Figueroa L, Xiong Y, Song C, Piao W, Vogel SN, Medvedev AE.

J Immunol. 2012 May 1;188(9):4506-15. doi: 10.4049/jimmunol.1200202. Epub 2012 Apr 2.


Pepsin digest of wheat gliadin fraction increases production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB signaling pathway and an NLRP3 inflammasome activation.

Palová-Jelínková L, Dáňová K, Drašarová H, Dvořák M, Funda DP, Fundová P, Kotrbová-Kozak A, Černá M, Kamanová J, Martin SF, Freudenberg M, Tučková L.

PLoS One. 2013 Apr 29;8(4):e62426. doi: 10.1371/journal.pone.0062426. Print 2013.


Toll-like receptor 4 agonists adsorbed to aluminium hydroxide adjuvant attenuate ovalbumin-specific allergic airway disease: role of MyD88 adaptor molecule and interleukin-12/interferon-gamma axis.

Bortolatto J, Borducchi E, Rodriguez D, Keller AC, Faquim-Mauro E, Bortoluci KR, Mucida D, Gomes E, Christ A, Schnyder-Candrian S, Schnyder B, Ryffel B, Russo M.

Clin Exp Allergy. 2008 Oct;38(10):1668-79. doi: 10.1111/j.1365-2222.2008.03036.x. Epub 2008 Jun 25.


MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant.

Orr MT, Duthie MS, Windish HP, Lucas EA, Guderian JA, Hudson TE, Shaverdian N, O'Donnell J, Desbien AL, Reed SG, Coler RN.

Eur J Immunol. 2013 Sep;43(9):2398-408. doi: 10.1002/eji.201243124. Epub 2013 Jul 3.


Differential requirements of MyD88 and TRIF pathways in TLR4-mediated immune responses in murine B cells.

Yanagibashi T, Nagai Y, Watanabe Y, Ikutani M, Hirai Y, Takatsu K.

Immunol Lett. 2015 Jan;163(1):22-31. doi: 10.1016/j.imlet.2014.11.012. Epub 2014 Nov 22.


Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling.

Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, Gretz N, Schaefer L, Kirschning CJ, Popovic ZV, Gröne HJ.

Dis Model Mech. 2010 Jan-Feb;3(1-2):92-103. doi: 10.1242/dmm.003533. Epub 2009 Dec 28.

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