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Items: 1 to 20 of 94

1.

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, Jia M, Jones D, Kok CY, Leroy C, Lin ML, McBride DJ, Maddison M, Maquire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, Pleasance E, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Collins VP, Ichimura K, Law S, Wong J, Yuen ST, Leung SY, Tonon G, DePinho RA, Tai YT, Anderson KC, Kahnoski RJ, Massie A, Khoo SK, Teh BT, Stratton MR, Futreal PA.

Nat Genet. 2009 May;41(5):521-3. doi: 10.1038/ng.349. Epub 2009 Mar 29.

2.

Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.

Hong S, Cho YW, Yu LR, Yu H, Veenstra TD, Ge K.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18439-44. Epub 2007 Nov 14.

3.

A histone H3 lysine 27 demethylase regulates animal posterior development.

Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y.

Nature. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12.

PMID:
17851529
4.

H3K27 demethylases, at long last.

Swigut T, Wysocka J.

Cell. 2007 Oct 5;131(1):29-32. Review.

5.

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K.

Nature. 2007 Oct 11;449(7163):731-4. Epub 2007 Aug 22.

PMID:
17713478
6.

Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.

Hübner MR, Spector DL.

Cold Spring Harb Symp Quant Biol. 2010;75:43-9. doi: 10.1101/sqb.2010.75.020. Epub 2011 Jan 5.

PMID:
21209387
7.

JMJD3 is a histone H3K27 demethylase.

Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD.

Cell Res. 2007 Oct;17(10):850-7.

8.

UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells.

Kim JH, Sharma A, Dhar SS, Lee SH, Gu B, Chan CH, Lin HK, Lee MG.

Cancer Res. 2014 Mar 15;74(6):1705-17. doi: 10.1158/0008-5472.CAN-13-1896. Epub 2014 Feb 3.

9.

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.

Shpargel KB, Sengoku T, Yokoyama S, Magnuson T.

PLoS Genet. 2012 Sep;8(9):e1002964. doi: 10.1371/journal.pgen.1002964. Epub 2012 Sep 27.

10.

The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.

Vandamme J, Lettier G, Sidoli S, Di Schiavi E, Nørregaard Jensen O, Salcini AE.

PLoS Genet. 2012;8(5):e1002647. doi: 10.1371/journal.pgen.1002647. Epub 2012 May 3.

11.

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination.

Ezponda T, Licht JD.

Clin Cancer Res. 2014 Oct 1;20(19):5001-8. doi: 10.1158/1078-0432.CCR-13-2499. Epub 2014 Jul 1. Review.

12.

JMJD3 as an epigenetic regulator in development and disease.

Burchfield JS, Li Q, Wang HY, Wang RF.

Int J Biochem Cell Biol. 2015 Oct;67:148-57. doi: 10.1016/j.biocel.2015.07.006. Epub 2015 Jul 17. Review.

PMID:
26193001
13.

Epigenetic regulation of the alternatively activated macrophage phenotype.

Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, Carson WF 4th, Cavassani KA, Li X, Lukacs NW, Hogaboam CM, Dou Y, Kunkel SL.

Blood. 2009 Oct 8;114(15):3244-54. doi: 10.1182/blood-2009-04-217620. Epub 2009 Jun 30.

14.

The role of the histone demethylase KDM4A in cancer.

Guerra-Calderas L, González-Barrios R, Herrera LA, Cantú de León D, Soto-Reyes E.

Cancer Genet. 2015 May;208(5):215-24. doi: 10.1016/j.cancergen.2014.11.001. Epub 2014 Nov 20. Review.

PMID:
25633974
15.

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, Davies H, Edkins S, Hardy C, Latimer C, Teague J, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Forbes S, Jia M, Jones D, Knott H, Kok CY, Lau KW, Leroy C, Lin ML, McBride DJ, Maddison M, Maguire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, O'Meara S, Pleasance E, Rajasingham A, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turrell K, Dykema KJ, Khoo SK, Petillo D, Wondergem B, Anema J, Kahnoski RJ, Teh BT, Stratton MR, Futreal PA.

Nature. 2010 Jan 21;463(7279):360-3. doi: 10.1038/nature08672. Epub 2010 Jan 6.

16.

Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.

Xu J, Deng X, Watkins R, Disteche CM.

J Neurosci. 2008 Apr 23;28(17):4521-7. doi: 10.1523/JNEUROSCI.5382-07.2008.

17.

Targeting the JMJD2A histone lysine demethylase.

Wilson JR.

Nat Struct Mol Biol. 2007 Aug;14(8):682-4. No abstract available.

PMID:
17676028
18.

The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner.

Copur Ö, Müller J.

Development. 2013 Aug;140(16):3478-85. doi: 10.1242/dev.097204.

19.

The H3K27me3 demethylase UTX in normal development and disease.

Van der Meulen J, Speleman F, Van Vlierberghe P.

Epigenetics. 2014 May;9(5):658-68. doi: 10.4161/epi.28298. Epub 2014 Feb 21. Review.

20.

Expression and significance of histone H3K27 demethylases in renal cell carcinoma.

Shen Y, Guo X, Wang Y, Qiu W, Chang Y, Zhang A, Duan X.

BMC Cancer. 2012 Oct 12;12:470. doi: 10.1186/1471-2407-12-470.

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