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Results: 1 to 20 of 102

1.

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology.

McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG.

Neurobiol Dis. 2009 Apr;34(1):163-77.

PMID:
19320056
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.

Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Knowlden SA, Wright TW, Bowers WJ.

Am J Pathol. 2011 Oct;179(4):2053-70. doi: 10.1016/j.ajpath.2011.07.001. Epub 2011 Aug 9.

PMID:
21835156
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer's disease.

Chavant F, Deguil J, Pain S, Ingrand I, Milin S, Fauconneau B, Pérault-Pochat MC, Lafay-Chebassier C.

J Pharmacol Exp Ther. 2010 Feb;332(2):505-14. doi: 10.1124/jpet.109.162164. Epub 2009 Nov 4.

PMID:
19889791
[PubMed - indexed for MEDLINE]
Free Article
4.

Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies.

Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ.

Am J Pathol. 2013 Jun;182(6):2285-97. doi: 10.1016/j.ajpath.2013.02.030. Epub 2013 Apr 6.

PMID:
23567638
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease.

Tweedie D, Ferguson RA, Fishman K, Frankola KA, Van Praag H, Holloway HW, Luo W, Li Y, Caracciolo L, Russo I, Barlati S, Ray B, Lahiri DK, Bosetti F, Greig NH, Rosi S.

J Neuroinflammation. 2012 May 29;9:106. doi: 10.1186/1742-2094-9-106.

PMID:
22642825
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice.

Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ.

Am J Pathol. 2008 Dec;173(6):1768-82. doi: 10.2353/ajpath.2008.080528. Epub 2008 Oct 30.

PMID:
18974297
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.

Pietri M, Dakowski C, Hannaoui S, Alleaume-Butaux A, Hernandez-Rapp J, Ragagnin A, Mouillet-Richard S, Haik S, Bailly Y, Peyrin JM, Launay JM, Kellermann O, Schneider B.

Nat Med. 2013 Sep;19(9):1124-31. doi: 10.1038/nm.3302. Epub 2013 Aug 18.

PMID:
23955714
[PubMed - indexed for MEDLINE]
8.

Transgenic mice as a model of pre-clinical Alzheimer's disease.

Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC.

Curr Alzheimer Res. 2011 Feb;8(1):4-23.

PMID:
21143159
[PubMed - indexed for MEDLINE]
9.

Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice.

Nelson RL, Guo Z, Halagappa VM, Pearson M, Gray AJ, Matsuoka Y, Brown M, Martin B, Iyun T, Maudsley S, Clark RF, Mattson MP.

Exp Neurol. 2007 May;205(1):166-76. Epub 2007 Feb 13.

PMID:
17368447
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.

Zhao J, O'Connor T, Vassar R.

J Neuroinflammation. 2011 Nov 2;8:150. doi: 10.1186/1742-2094-8-150.

PMID:
22047170
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Hydrogen sulfide slows down progression of experimental Alzheimer's disease by targeting multiple pathophysiological mechanisms.

Giuliani D, Ottani A, Zaffe D, Galantucci M, Strinati F, Lodi R, Guarini S.

Neurobiol Learn Mem. 2013 Sep;104:82-91. doi: 10.1016/j.nlm.2013.05.006. Epub 2013 May 31.

PMID:
23726868
[PubMed - indexed for MEDLINE]
12.

S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.

Zhang W, Zhang W, Li Z, Hao J, Zhang Z, Liu L, Mao N, Miao J, Zhang L.

Pharmacol Biochem Behav. 2012 Jan;100(3):361-9. doi: 10.1016/j.pbb.2011.09.012. Epub 2011 Oct 2.

PMID:
21993310
[PubMed - indexed for MEDLINE]
13.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG.

Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.

PMID:
24315369
[PubMed - indexed for MEDLINE]
14.

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.

Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T.

Am J Pathol. 2007 Feb;170(2):680-92.

PMID:
17255335
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease.

Gabbita SP, Srivastava MK, Eslami P, Johnson MF, Kobritz NK, Tweedie D, Greig NH, Zemlan FP, Sharma SP, Harris-White ME.

J Neuroinflammation. 2012 May 25;9:99. doi: 10.1186/1742-2094-9-99.

PMID:
22632257
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.

Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT.

J Neurosci. 2010 Feb 17;30(7):2442-53. doi: 10.1523/JNEUROSCI.5038-09.2010.

PMID:
20164328
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice.

He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, Staufenbiel M, Li R, Shen Y.

J Cell Biol. 2007 Aug 27;178(5):829-41.

PMID:
17724122
[PubMed - indexed for MEDLINE]
Free PMC Article
18.
19.

Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease.

Stöhr O, Schilbach K, Moll L, Hettich MM, Freude S, Wunderlich FT, Ernst M, Zemva J, Brüning JC, Krone W, Udelhoven M, Schubert M.

Age (Dordr). 2013 Feb;35(1):83-101. doi: 10.1007/s11357-011-9333-2. Epub 2011 Nov 6.

PMID:
22057897
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.

McCoy MK, Martinez TN, Ruhn KA, Szymkowski DE, Smith CG, Botterman BR, Tansey KE, Tansey MG.

J Neurosci. 2006 Sep 13;26(37):9365-75.

PMID:
16971520
[PubMed - indexed for MEDLINE]
Free PMC Article

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