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Results: 1 to 20 of 100

1.

Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression.

Wingate H, Puskas A, Duong M, Bui T, Richardson D, Liu Y, Tucker SL, Van Pelt C, Meijer L, Hunt K, Keyomarsi K.

Cell Cycle. 2009 Apr 1;8(7):1062-8. Epub 2009 Apr 10.

PMID:
19305161
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer.

Akli S, Zheng PJ, Multani AS, Wingate HF, Pathak S, Zhang N, Tucker SL, Chang S, Keyomarsi K.

Cancer Res. 2004 May 1;64(9):3198-208.

PMID:
15126360
[PubMed - indexed for MEDLINE]
Free Article
3.

Targeting low molecular weight cyclin E (LMW-E) in breast cancer.

Nanos-Webb A, Jabbour NA, Multani AS, Wingate H, Oumata N, Galons H, Joseph B, Meijer L, Hunt KK, Keyomarsi K.

Breast Cancer Res Treat. 2012 Apr;132(2):575-88. doi: 10.1007/s10549-011-1638-4. Epub 2011 Jun 22.

PMID:
21695458
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The low molecular weight (LMW) isoforms of cyclin E deregulate the cell cycle of mammary epithelial cells.

Wingate H, Bedrosian I, Akli S, Keyomarsi K.

Cell Cycle. 2003 Sep-Oct;2(5):461-6.

PMID:
12963845
[PubMed - indexed for MEDLINE]
Free Article
5.

LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients.

Duong MT, Akli S, Wei C, Wingate HF, Liu W, Lu Y, Yi M, Mills GB, Hunt KK, Keyomarsi K.

PLoS Genet. 2012;8(3):e1002538. doi: 10.1371/journal.pgen.1002538. Epub 2012 Mar 29.

PMID:
22479189
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E.

Akli S, Van Pelt CS, Bui T, Meijer L, Keyomarsi K.

Cancer Res. 2011 May 1;71(9):3377-86. doi: 10.1158/0008-5472.CAN-10-4086. Epub 2011 Mar 8.

PMID:
21385896
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Low-molecular-weight cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors.

Akli S, Bui T, Wingate H, Biernacka A, Moulder S, Tucker SL, Hunt KK, Keyomarsi K.

Clin Cancer Res. 2010 Feb 15;16(4):1179-90. doi: 10.1158/1078-0432.CCR-09-1787. Epub 2010 Feb 9.

PMID:
20145171
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells.

Duong MT, Akli S, Macalou S, Biernacka A, Debeb BG, Yi M, Hunt KK, Keyomarsi K.

Cancer Res. 2013 Sep 1;73(17):5556-68. doi: 10.1158/0008-5472.CAN-13-0013. Epub 2013 Aug 16.

PMID:
23955388
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Why are the truncated cyclin Es more effective CDK2 activators than the full-length isoforms?

Rath SL, Senapati S.

Biochemistry. 2014 Jul 22;53(28):4612-24. doi: 10.1021/bi5004052. Epub 2014 Jul 10.

PMID:
24947816
[PubMed - indexed for MEDLINE]
10.

Low molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification.

Bagheri-Yarmand R, Biernacka A, Hunt KK, Keyomarsi K.

Cancer Res. 2010 Jun 15;70(12):5074-84. doi: 10.1158/0008-5472.CAN-09-4094. Epub 2010 Jun 8.

PMID:
20530685
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer.

Akli S, Zhang XQ, Bondaruk J, Tucker SL, Czerniak PB, Benedict WF, Keyomarsi K.

Cell Cycle. 2012 Apr 1;11(7):1468-76. doi: 10.4161/cc.19882. Epub 2012 Apr 1.

PMID:
22441703
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C.

Bagheri-Yarmand R, Nanos-Webb A, Biernacka A, Bui T, Keyomarsi K.

Cancer Res. 2010 Jun 15;70(12):5085-95. doi: 10.1158/0008-5472.CAN-09-4095. Epub 2010 Jun 8.

PMID:
20530684
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27.

Wingate H, Zhang N, McGarhen MJ, Bedrosian I, Harper JW, Keyomarsi K.

J Biol Chem. 2005 Apr 15;280(15):15148-57. Epub 2005 Feb 10.

PMID:
15708847
[PubMed - indexed for MEDLINE]
Free Article
14.

Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway.

Akli S, Van Pelt CS, Bui T, Multani AS, Chang S, Johnson D, Tucker S, Keyomarsi K.

Cancer Res. 2007 Aug 1;67(15):7212-22.

PMID:
17671189
[PubMed - indexed for MEDLINE]
Free Article
15.

Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells.

Harwell RM, Mull BB, Porter DC, Keyomarsi K.

J Biol Chem. 2004 Mar 26;279(13):12695-705. Epub 2003 Dec 29.

PMID:
14701826
[PubMed - indexed for MEDLINE]
Free Article
16.

Altered subcellular localization of tumor-specific cyclin E isoforms affects cyclin-dependent kinase 2 complex formation and proteasomal regulation.

Delk NA, Hunt KK, Keyomarsi K.

Cancer Res. 2009 Apr 1;69(7):2817-25. doi: 10.1158/0008-5472.CAN-08-4182. Epub 2009 Mar 24.

PMID:
19318554
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Detection of low molecular weight derivatives of cyclin E1 is a function of cyclin E1 protein levels in breast cancer.

Spruck C, Sun D, Fiegl H, Marth C, Mueller-Holzner E, Goebel G, Widschwendter M, Reed SI.

Cancer Res. 2006 Jul 15;66(14):7355-60.

PMID:
16849587
[PubMed - indexed for MEDLINE]
Free Article
18.

Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms.

Porter DC, Zhang N, Danes C, McGahren MJ, Harwell RM, Faruki S, Keyomarsi K.

Mol Cell Biol. 2001 Sep;21(18):6254-69.

PMID:
11509668
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Low-molecular-weight cyclin E: the missing link between biology and clinical outcome.

Akli S, Keyomarsi K.

Breast Cancer Res. 2004;6(5):188-91. Epub 2004 Jul 7.

PMID:
15318923
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Tumor-specific hyperactive low-molecular-weight cyclin E isoforms detection and characterization in non-metastatic colorectal tumors.

Corin I, Di Giacomo MC, Lastella P, Bagnulo R, Guanti G, Simone C.

Cancer Biol Ther. 2006 Feb;5(2):198-203. Epub 2006 Feb 28.

PMID:
16397408
[PubMed - indexed for MEDLINE]
Free Article

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