Similar articles for PMID: 19302196

Year	Number of Results
1993	1
1997	1
1998	1
2000	1
2001	1
2002	1
2003	2
2004	2
2005	2
2006	5
2007	8
2008	4
2009	17
2010	15
2011	7
2012	13
2013	12
2014	13
2015	6
2016	2
2017	5
2018	1
2020	1
2021	1
2024	0

1

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.

Gloeckner CJ, Schumacher A, Boldt K, Ueffing M. Gloeckner CJ, et al. J Neurochem. 2009 May;109(4):959-68. doi: 10.1111/j.1471-4159.2009.06024.x. Epub 2009 Mar 3. J Neurochem. 2009. PMID: 19302196 Free article.

2

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.

Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M. Gloeckner CJ, et al. Hum Mol Genet. 2006 Jan 15;15(2):223-32. doi: 10.1093/hmg/ddi439. Epub 2005 Dec 1. Hum Mol Genet. 2006. PMID: 16321986

3

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL. Chen CY, et al. Cell Death Differ. 2012 Oct;19(10):1623-33. doi: 10.1038/cdd.2012.42. Epub 2012 Apr 27. Cell Death Differ. 2012. PMID: 22539006 Free PMC article.

4

Identification of the autophosphorylation sites of LRRK2.

Kamikawaji S, Ito G, Iwatsubo T. Kamikawaji S, et al. Biochemistry. 2009 Nov 24;48(46):10963-75. doi: 10.1021/bi9011379. Biochemistry. 2009. PMID: 19824698

5

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways.

Takekawa M, Posas F, Saito H. Takekawa M, et al. EMBO J. 1997 Aug 15;16(16):4973-82. doi: 10.1093/emboj/16.16.4973. EMBO J. 1997. PMID: 9305639 Free PMC article.

6

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon CE, Dominguez SL, Solanoy HO, Drummond J, Zhang X, Ding X, Cai F, Song Q, Li X, Yue Z, van der Brug MP, Burdick DJ, Gunzner-Toste J, Chen H, Liu X, Estrada AA, Sweeney ZK, Scearce-Levie K, Moffat JG, Kirkpatrick DS, Zhu H. Sheng Z, et al. Sci Transl Med. 2012 Dec 12;4(164):164ra161. doi: 10.1126/scitranslmed.3004485. Sci Transl Med. 2012. PMID: 23241745

7

Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity.

Reichling LJ, Riddle SM. Reichling LJ, et al. Biochem Biophys Res Commun. 2009 Jun 26;384(2):255-8. doi: 10.1016/j.bbrc.2009.04.098. Epub 2009 May 3. Biochem Biophys Res Commun. 2009. PMID: 19397894

8

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.

Heo HY, Park JM, Kim CH, Han BS, Kim KS, Seol W. Heo HY, et al. Exp Cell Res. 2010 Feb 15;316(4):649-56. doi: 10.1016/j.yexcr.2009.09.014. Epub 2009 Sep 19. Exp Cell Res. 2010. PMID: 19769964

9

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation.

Luzón-Toro B, Rubio de la Torre E, Delgado A, Pérez-Tur J, Hilfiker S. Luzón-Toro B, et al. Hum Mol Genet. 2007 Sep 1;16(17):2031-9. doi: 10.1093/hmg/ddm151. Epub 2007 Jun 20. Hum Mol Genet. 2007. PMID: 17584768

10

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications.

Qing H, Wong W, McGeer EG, McGeer PL. Qing H, et al. Biochem Biophys Res Commun. 2009 Sep 11;387(1):149-52. doi: 10.1016/j.bbrc.2009.06.142. Epub 2009 Jul 1. Biochem Biophys Res Commun. 2009. PMID: 19576176

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