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Results: 1 to 20 of 241

1.

Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.

Hall SE, Mao A, Nicolaidou V, Finelli M, Wise EL, Nedjai B, Kanjanapangka J, Harirchian P, Chen D, Selchau V, Ribeiro S, Schyler S, Pease JE, Horuk R, Vaidehi N.

Mol Pharmacol. 2009 Jun;75(6):1325-36. doi: 10.1124/mol.108.053470. Epub 2009 Mar 18.

PMID:
19297521
[PubMed - indexed for MEDLINE]
Free Article
2.

The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis.

Tokuyama H, Ueha S, Kurachi M, Matsushima K, Moriyasu F, Blumberg RS, Kakimi K.

Int Immunol. 2005 Aug;17(8):1023-34. Epub 2005 Jul 6.

PMID:
16000328
[PubMed - indexed for MEDLINE]
Free Article
3.

The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3.

Gao P, Zhou XY, Yashiro-Ohtani Y, Yang YF, Sugimoto N, Ono S, Nakanishi T, Obika S, Imanishi T, Egawa T, Nagasawa T, Fujiwara H, Hamaoka T.

J Leukoc Biol. 2003 Feb;73(2):273-80.

PMID:
12554804
[PubMed - indexed for MEDLINE]
Free Article
4.

Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.

Paterlini MG.

Biophys J. 2002 Dec;83(6):3012-31.

PMID:
12496074
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study.

Kothandan G, Gadhe CG, Cho SJ.

PLoS One. 2012;7(3):e32864. doi: 10.1371/journal.pone.0032864. Epub 2012 Mar 27.

PMID:
22479344
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Binding of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines to human CCR5: a molecular modeling-guided mutagenesis study of the binding pocket.

Castonguay LA, Weng Y, Adolfsen W, Di Salvo J, Kilburn R, Caldwell CG, Daugherty BL, Finke PE, Hale JJ, Lynch CL, Mills SG, MacCoss M, Springer MS, DeMartino JA.

Biochemistry. 2003 Feb 18;42(6):1544-50.

PMID:
12578367
[PubMed - indexed for MEDLINE]
7.

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety.

Shiraishi M, Aramaki Y, Seto M, Imoto H, Nishikawa Y, Kanzaki N, Okamoto M, Sawada H, Nishimura O, Baba M, Fujino M.

J Med Chem. 2000 May 18;43(10):2049-63.

PMID:
10821717
[PubMed - indexed for MEDLINE]
8.

Building three-dimensional structures of HIV-1 coreceptor CCR5 and its interaction with antagonist TAK779 by comparative molecular modeling.

Huang XQ, Jiang HL, Luo XM, Chen KX, Ji RY, Cao Y, Pei G.

Acta Pharmacol Sin. 2000 Jun;21(6):521-8.

PMID:
11360686
[PubMed - indexed for MEDLINE]
Free Article
9.

Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.

Thiele S, Steen A, Jensen PC, Mokrosinski J, Frimurer TM, Rosenkilde MM.

J Biol Chem. 2011 Oct 28;286(43):37543-54. doi: 10.1074/jbc.M111.243808. Epub 2011 Aug 30.

PMID:
21878623
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists.

Sohy D, Yano H, de Nadai P, Urizar E, Guillabert A, Javitch JA, Parmentier M, Springael JY.

J Biol Chem. 2009 Nov 6;284(45):31270-9. doi: 10.1074/jbc.M109.054809. Epub 2009 Sep 15.

PMID:
19758998
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Expression and characterization of the chemokine receptor CCR2B from rhesus monkey.

Jin H, Vicario PP, Zweerink H, Goyal S, Hanlon WA, Dorn CP, Mills SG, DeMartino JA, Cascieri MA, Struthers M.

Biochem Pharmacol. 2003 Jul 15;66(2):321-30.

PMID:
12826275
[PubMed - indexed for MEDLINE]
12.

Chemokine receptor blockade with a synthetic nonpeptide compound attenuates cardiac allograft vasculopathy.

Bastani S, Sherman W, Schnickel GT, Hsieh GR, Bhatia R, Fishbein MC, Ardehali A.

Transplantation. 2009 Oct 27;88(8):995-1001. doi: 10.1097/TP.0b013e3181b9ccd5.

PMID:
19855245
[PubMed - indexed for MEDLINE]
13.

Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis.

Lagane B, Ballet S, Planchenault T, Balabanian K, Le Poul E, Blanpain C, Percherancier Y, Staropoli I, Vassart G, Oppermann M, Parmentier M, Bachelerie F.

Mol Pharmacol. 2005 Jun;67(6):1966-76. Epub 2005 Mar 10.

PMID:
15761117
[PubMed - indexed for MEDLINE]
Free Article
14.

Molecular interactions of CCR5 with major classes of small-molecule anti-HIV CCR5 antagonists.

Kondru R, Zhang J, Ji C, Mirzadegan T, Rotstein D, Sankuratri S, Dioszegi M.

Mol Pharmacol. 2008 Mar;73(3):789-800. Epub 2007 Dec 20.

PMID:
18096812
[PubMed - indexed for MEDLINE]
Free Article
15.

Chapter 12. The use of receptor homology modeling to facilitate the design of selective chemokine receptor antagonists.

Carter PH, Tebben AJ.

Methods Enzymol. 2009;461:249-79. doi: 10.1016/S0076-6879(09)05412-3.

PMID:
19480923
[PubMed - indexed for MEDLINE]
16.

The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor.

Watson C, Jenkinson S, Kazmierski W, Kenakin T.

Mol Pharmacol. 2005 Apr;67(4):1268-82. Epub 2005 Jan 11.

PMID:
15644495
[PubMed - indexed for MEDLINE]
Free Article
17.

CCR2 and CCR5 receptor-binding properties of herpesvirus-8 vMIP-II based on sequence analysis and its solution structure.

Shao W, Fernandez E, Sachpatzidis A, Wilken J, Thompson DA, Schweitzer BI, Lolis E.

Eur J Biochem. 2001 May;268(10):2948-59.

PMID:
11358512
[PubMed - indexed for MEDLINE]
Free Article
18.

Synthesis of [19, 35, 36-(13)C(3)]-labeled TAK779 as a molecular probe.

Konno H, Aimoto S, Smith SO, Nosaka K, Akaji K.

Bioorg Med Chem. 2009 Aug 15;17(16):5769-74. doi: 10.1016/j.bmc.2009.07.026. Epub 2009 Jul 18.

PMID:
19640721
[PubMed - indexed for MEDLINE]
19.

A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection.

Akashi S, Sho M, Kashizuka H, Hamada K, Ikeda N, Kuzumoto Y, Tsurui Y, Nomi T, Mizuno T, Kanehiro H, Hisanaga M, Ko S, Nakajima Y.

Transplantation. 2005 Aug 15;80(3):378-84.

PMID:
16082334
[PubMed - indexed for MEDLINE]
20.

Cloning and functional characterization of the rabbit C-C chemokine receptor 2.

Lu D, Yuan XJ, Evans RJ Jr, Pappas AT, Wang H, Su EW, Hamdouchi C, Venkataraman C.

BMC Immunol. 2005 Jul 7;6:15.

PMID:
16001983
[PubMed - indexed for MEDLINE]
Free PMC Article

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