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Items: 1 to 20 of 193


Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.

Barker RH Jr, Liu H, Hirth B, Celatka CA, Fitzpatrick R, Xiang Y, Willert EK, Phillips MA, Kaiser M, Bacchi CJ, Rodriguez A, Yarlett N, Klinger JD, Sybertz E.

Antimicrob Agents Chemother. 2009 May;53(5):2052-8. doi: 10.1128/AAC.01674-08. Epub 2009 Mar 16.


Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Barker RH Jr, Rodriguez A, Hirth B, Rattendi D, Yarlett N, Hendrick CL, Sybertz E.

Antimicrob Agents Chemother. 2009 Aug;53(8):3269-72. doi: 10.1128/AAC.00076-09. Epub 2009 May 18.


Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase.

Bitonti AJ, Byers TL, Bush TL, Casara PJ, Bacchi CJ, Clarkson AB Jr, McCann PP, Sjoerdsma A.

Antimicrob Agents Chemother. 1990 Aug;34(8):1485-90.


Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.

Wenzler T, Yang S, Braissant O, Boykin DW, Brun R, Wang MZ.

Antimicrob Agents Chemother. 2013 Nov;57(11):5330-43. doi: 10.1128/AAC.00398-13. Epub 2013 Aug 19.


Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

Hirth B, Barker RH Jr, Celatka CA, Klinger JD, Liu H, Nare B, Nijjar A, Phillips MA, Sybertz E, Willert EK, Xiang Y.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2916-9. doi: 10.1016/j.bmcl.2009.04.096. Epub 2009 Apr 24.


In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides.

Bacchi CJ, Sanabria K, Spiess AJ, Vargas M, Marasco CJ Jr, Jimenez LM, Goldberg B, Sufrin JR.

Antimicrob Agents Chemother. 1997 Oct;41(10):2108-12.


Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.

Vodnala SK, Lundbäck T, Yeheskieli E, Sjöberg B, Gustavsson AL, Svensson R, Olivera GC, Eze AA, de Koning HP, Hammarström LG, Rottenberg ME.

J Med Chem. 2013 Dec 27;56(24):9861-73. doi: 10.1021/jm401530a. Epub 2013 Dec 10.


Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug.

Huang TL, Bacchi CJ, Kode NR, Zhang Q, Wang G, Yartlet N, Rattendi D, Londono I, Mazumder L, Vanden Eynde JJ, Mayence A, Donkor IO.

Int J Antimicrob Agents. 2007 Dec;30(6):555-61. Epub 2007 Oct 24.


In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.

Bacchi CJ, Brun R, Croft SL, Alicea K, Bühler Y.

Antimicrob Agents Chemother. 1996 Jun;40(6):1448-53.


Novel trypanocidal analogs of 5'-(methylthio)-adenosine.

Sufrin JR, Spiess AJ, Marasco CJ Jr, Rattendi D, Bacchi CJ.

Antimicrob Agents Chemother. 2008 Jan;52(1):211-9. Epub 2007 Oct 22.


3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, Baell JB.

Eur J Med Chem. 2013 Aug;66:450-65. doi: 10.1016/j.ejmech.2013.05.007. Epub 2013 May 16.


Cynaropicrin: the first plant natural product with in vivo activity against Trypanosoma brucei.

Zimmermann S, Kaiser M, Brun R, Hamburger M, Adams M.

Planta Med. 2012 Apr;78(6):553-6. doi: 10.1055/s-0031-1298241. Epub 2012 Feb 13.


Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Bitonti AJ, Sjoerdsma A.

Antimicrob Agents Chemother. 1992 Dec;36(12):2736-40.


Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness.

Kaiser M, Bray MA, Cal M, Bourdin Trunz B, Torreele E, Brun R.

Antimicrob Agents Chemother. 2011 Dec;55(12):5602-8. doi: 10.1128/AAC.00246-11. Epub 2011 Sep 12.


Antitrypanosomal activity of purine nucleosides can be enhanced by their conversion to O-acetylated derivatives.

Sufrin JR, Rattendi D, Spiess AJ, Lane S, Marasco CJ Jr, Bacchi CJ.

Antimicrob Agents Chemother. 1996 Nov;40(11):2567-72.


Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity.

Marasco CJ Jr, Kramer DL, Miller J, Porter CW, Bacchi CJ, Rattendi D, Kucera L, Iyer N, Bernacki R, Pera P, Sufrin JR.

J Med Chem. 2002 Nov 7;45(23):5112-22.


Trypanocidal activity of dicationic compounds related to pentamidine.

Donkor IO, Assefa H, Rattendi D, Lane S, Vargas M, Goldberg B, Bacchi C.

Eur J Med Chem. 2001 Jun;36(6):531-8.

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