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Endurance exercise is protective for mice with mitochondrial myopathy.

Wenz T, Diaz F, Hernandez D, Moraes CT.

J Appl Physiol (1985). 2009 May;106(5):1712-9. doi: 10.1152/japplphysiol.91571.2008. Epub 2009 Mar 12.


Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype.

Wenz T, Diaz F, Spiegelman BM, Moraes CT.

Cell Metab. 2008 Sep;8(3):249-56. doi: 10.1016/j.cmet.2008.07.006.


PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle.

Geng T, Li P, Okutsu M, Yin X, Kwek J, Zhang M, Yan Z.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C572-9. doi: 10.1152/ajpcell.00481.2009. Epub 2009 Dec 23.


Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.

Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S.

J Biol Chem. 2011 Sep 2;286(35):30561-70. doi: 10.1074/jbc.M111.261685. Epub 2011 Jul 11.


Mitochondrial biogenesis and peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is required.

Li L, Pan R, Li R, Niemann B, Aurich AC, Chen Y, Rohrbach S.

Diabetes. 2011 Jan;60(1):157-67. doi: 10.2337/db10-0331. Epub 2010 Oct 7.


Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake.

Tadaishi M, Miura S, Kai Y, Kano Y, Oishi Y, Ezaki O.

PLoS One. 2011;6(12):e28290. doi: 10.1371/journal.pone.0028290. Epub 2011 Dec 8.


Muscle type-specific response of PGC-1 alpha and oxidative enzymes during voluntary wheel running in mouse skeletal muscle.

Ikeda S, Kawamoto H, Kasaoka K, Hitomi Y, Kizaki T, Sankai Y, Ohno H, Haga S, Takemasa T.

Acta Physiol (Oxf). 2006 Nov-Dec;188(3-4):217-23.


Training-induced mitochondrial adaptation: role of peroxisome proliferator-activated receptor γ coactivator-1α, nuclear factor-κB and β-blockade.

Feng H, Kang C, Dickman JR, Koenig R, Awoyinka I, Zhang Y, Ji LL.

Exp Physiol. 2013 Mar;98(3):784-95. doi: 10.1113/expphysiol.2012.069286. Epub 2012 Oct 26.


Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.

Safdar A, Little JP, Stokl AJ, Hettinga BP, Akhtar M, Tarnopolsky MA.

J Biol Chem. 2011 Mar 25;286(12):10605-17. doi: 10.1074/jbc.M110.211466. Epub 2011 Jan 18.


Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle.

Li L, Mühlfeld C, Niemann B, Pan R, Li R, Hilfiker-Kleiner D, Chen Y, Rohrbach S.

Basic Res Cardiol. 2011 Nov;106(6):1221-34. doi: 10.1007/s00395-011-0213-9. Epub 2011 Aug 28.


The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle.

Adhihetty PJ, Uguccioni G, Leick L, Hidalgo J, Pilegaard H, Hood DA.

Am J Physiol Cell Physiol. 2009 Jul;297(1):C217-25. doi: 10.1152/ajpcell.00070.2009. Epub 2009 May 13.


PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

Leick L, Wojtaszewski JF, Johansen ST, Kiilerich K, Comes G, Hellsten Y, Hidalgo J, Pilegaard H.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E463-74. Epub 2007 Dec 11.


Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α.

Kang C, Chung E, Diffee G, Ji LL.

Exp Gerontol. 2013 Nov;48(11):1343-50. doi: 10.1016/j.exger.2013.08.004. Epub 2013 Aug 30.


TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice.

Luo Z, Ma L, Zhao Z, He H, Yang D, Feng X, Ma S, Chen X, Zhu T, Cao T, Liu D, Nilius B, Huang Y, Yan Z, Zhu Z.

Cell Res. 2012 Mar;22(3):551-64. doi: 10.1038/cr.2011.205. Epub 2011 Dec 20.


Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α.

Ringholm S, Olesen J, Pedersen JT, Brandt CT, Halling JF, Hellsten Y, Prats C, Pilegaard H.

Exp Gerontol. 2013 Nov;48(11):1311-8. doi: 10.1016/j.exger.2013.08.012. Epub 2013 Aug 29.


Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle.

Suwa M, Nakano H, Radak Z, Kumagai S.

Metabolism. 2008 Jul;57(7):986-98. doi: 10.1016/j.metabol.2008.02.017.


Mild heat stress induces mitochondrial biogenesis in C2C12 myotubes.

Liu CT, Brooks GA.

J Appl Physiol (1985). 2012 Feb;112(3):354-61. doi: 10.1152/japplphysiol.00989.2011. Epub 2011 Nov 3.


Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle.

Gurd BJ, Yoshida Y, McFarlan JT, Holloway GP, Moyes CD, Heigenhauser GJ, Spriet L, Bonen A.

Am J Physiol Regul Integr Comp Physiol. 2011 Jul;301(1):R67-75. doi: 10.1152/ajpregu.00417.2010. Epub 2011 May 4.


miRNA in the regulation of skeletal muscle adaptation to acute endurance exercise in C57Bl/6J male mice.

Safdar A, Abadi A, Akhtar M, Hettinga BP, Tarnopolsky MA.

PLoS One. 2009;4(5):e5610. doi: 10.1371/journal.pone.0005610. Epub 2009 May 19.


Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood.

Laker RC, Wlodek ME, Wadley GD, Gallo LA, Meikle PJ, McConell GK.

Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1221-30. doi: 10.1152/ajpendo.00583.2011. Epub 2012 Feb 21.

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